The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis

Biomaterials

Volumn 33, Issue 33, 2012, Pages 8600-8612

  Park, Ji Sun ^a   Yang, Han Na ^a   Jeon, Su Yeon ^a   Woo, Dae Gyun ^b   Kim, Moon Suk ^c   Park, Keun Hong ^a  

^a CHA University   (South Korea)

^b Chabiotech Co Ltd   (South Korea)

^c Ajou University   (South Korea)

Author keywords

COX 2; Dexamethasone; INOS; PLGA nanoparticles; SiRNA

Indexed keywords

COX-2; DEXAMETHASONES; INOS; PLGA NANOPARTICLES; SIRNA;

BODY FLUIDS; CELL CULTURE; CELLS; DRUG DELIVERY; DRUG PRODUCTS; LOADING; MOLECULAR BIOLOGY; NANOPARTICLES; POLYMERASE CHAIN REACTION; SWITCHING CIRCUITS;

GENE EXPRESSION;

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 ANTIBODY; DEXAMETHASONE; ENZYME ANTIBODY; GREEN FLUORESCENT PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NANOPARTICLE; NANOSPHERE; POLYETHYLENEIMINE; POLYGLACTIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS;

APOPTOSIS; ARTHRITIS, RHEUMATOID; CASPASE 3; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DEXAMETHASONE; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; LACTIC ACID; NANOPARTICLES; NITRIC OXIDE SYNTHASE TYPE II; POLYGLYCOLIC ACID; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866151981     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.008     Document Type: Article

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