Enhanced siRNA delivery and silencing gold-chitosan nanosystem with surface charge-reversal polymer assembly and good biocompatibility

ACS Nano

Volumn 6, Issue 8, 2012, Pages 7340-7351

  Han, Lu ^a   Zhao, Jing ^a,b   Zhang, Xu ^a   Cao, Weipeng ^a   Hu, Xixue ^a   Zou, Guozhang ^a   Duan, Xianglin ^b   Liang, Xing Jie ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b HEBEI NORMAL UNIVERSITY   (China)

Author keywords

charge reversible; layer by layer assembly; siRNA

Indexed keywords

CHARGE-REVERSIBLE; DOXORUBICIN; ENDOSOMES; ENZYMATIC DEGRADATION; GENE SILENCING; GOLD NANOPARTICLE; HELA CELL; IN-VITRO; IN-VIVO; LAYER-BY-LAYER ASSEMBLIES; MASS RATIO; MCF-7 CELLS; NANOCARRIERS; PH-RESPONSIVE; POLYETHYLENIMINES; POLYMER ASSEMBLIES; POSITIVELY CHARGED; SIRNA; SIRNA DELIVERY; TRANSFECTION REAGENTS;

BIOCOMPATIBILITY; CHITOSAN; DEGRADATION; GENE ENCODING; GENETIC ENGINEERING; LOADING; POLYMERS; RNA;

NANOSYSTEMS;

BIOMATERIAL; CHITOSAN; GOLD; NANOCAPSULE; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN MCF 7; CHEMISTRY; GENE SILENCING; GENE TRANSFER; HELA CELL; HUMAN; MATERIALS TESTING; STATIC ELECTRICITY; SYNTHESIS; ULTRASTRUCTURE;

BIOCOMPATIBLE MATERIALS; CHITOSAN; GENE SILENCING; GENE TRANSFER TECHNIQUES; GOLD; HELA CELLS; HUMANS; MATERIALS TESTING; MCF-7 CELLS; NANOCAPSULES; RNA, SMALL INTERFERING; STATIC ELECTRICITY;

EID: 84865593611     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn3024688     Document Type: Article

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