Effect of preparative variables on small interfering RNA loaded Poly(D,L-lactide-co-glycolide)-chitosan submicron particles prepared by emulsification diffusion method

Journal of Microencapsulation

Volumn 25, Issue 8, 2008, Pages 541-548

  Katas, Haliza ^a   Chen, Shu ^a   Osamuyimen, Adebayo Adetayo ^a   Cevher, Erdal ^a,b   Alpar, H Oya ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Chitosan; Emulsification diffusion method; Gene silencing; Nanoparticles; Poly (D,L lactide co glycolide); siRNA

Indexed keywords

CHITOSAN; NANOPARTICLE; POLYGLACTIN; SMALL INTERFERING RNA; TREHALOSE;

ARTICLE; CENTRIFUGATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; EMULSION; FREEZE DRYING; MOLECULAR WEIGHT; PARTICLE SIZE; PROCESS OPTIMIZATION;

CHITOSAN; DIFFUSION; DRUG CARRIERS; EMULSIONS; FREEZE DRYING; LACTIC ACID; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; RNA, SMALL INTERFERING;

EID: 56349083343     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040802075567     Document Type: Article

References (22)

1. Agnihotri, SA, Mallikarjuna, NN and Aminabhavi, TM (2004) Recent advances on chitosan-based micro- and nanoparticles in drug delivery. J Control Release, 100, pp. 5-28.
2. Allison, SD, Molina, MDC and Anchordoguy, TJ (2000) Stabilisation of lipid/DNA complexes during the freeze-drying step of the lyophilization process: The particle isolation hypothesis. Biochim Biophys Acta, 146, pp. 127-138.
3. Armstrong, TK and Anchordoguy, TJ (2004) Immobilization of nonviral vectors during the freeze step of lyophilization. J Pharm Sci, 93, pp. 2698-2709.
4. Brus, C., Kleeman, E., Aigner, A., Czubayko, F. and Kissel, T. (2004) Stabilisation of oligonucleotide-polyethyleimine complexes by freeze-drying: Physicochemical and biological characterization. J Control Release, 95, pp. 119-131.
5. Janes, KA, Calvo, P. and Alonso, MJ (2001) Polysaccharide colloidal particles as delivery systems for macromolecules. Adv Drug Deliv Rev, 47, pp. 83-97.
6. Kost, J. and Goldbart, R. (1997) Natural and modified polysaccharides. Handbook of biodegradable and polymers, pp. 275-289. Hardwood Academic Publishers, Amsterdam
7. Kuo, J-H and Hwang, R. (2004) Preparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: Effect of protective agents (polyethyleneimine and sugars) on the stability of DNA. J Pharm Pharmacol, 5, pp. 27-33.
8. Lee, MK, Chun, SK, Choi, WJ, Kim, JK, Choi, SH, Kim, A., Oungbho, K., Park, JS, Ahn, WS and Kim, CK (2005) The use of chitosan as a condensing agent to enhance emulsion-mediated gene transfer. Biomaterials, 26, pp. 2147-2156.
9. Li, XW, Lee, DKL, Chan, ASC and Alpar, HO (2003) Sustained expression in mammalian cells with DNA complexed with chitosan nanoparticles. Biochim Biophys Acta Gene Struct Expression, 1630, pp. 7-18.
10. Lopez-Leon, T., Carvalho, ELS, Seijo, B., Ortega-Vinuesa, JL and Bastos-Gonzalez, D. (2005) Physicochemical characterization of chitosan nanoparticles: Electrokinetic and stability behavior. J Colloid Interf Sci, 283, pp. 344-351.
11. Messai, I. and Delair, T. (2006) Cationic biodegradable particles: Comparison of one or two step processes. Colloids Surf A-Physicochem Eng Aspects, 278, pp. 188-196.
12. Messai, I., Lamalle, D., Munier, S., Verrier, B., Ataman-Onal, Y. and Delair, T. (2005) Poly(,-lactic acid) and chitosan complexes: Interactions with plasmid DNA. Colloids Surf A-Physicochem Eng Aspects, 255, pp. 65-72.
13. Molina, MC, Amstrong, TK, Zhang, Y., Patel, MM, Lentz, YK and Anchordoguy, TJ (2004) The stability of lyophilized lipid/DNA complexes during prolonged storage. J Pharm Sci, 93, pp. 2259-2273.
14. Munier, S., Messai, I., Delair, T., Verrier, B. and Ataman-Onal, Y. (2005) Cationic PLA nanoparticles for DNA delivery: Comparison of three surface polycations for DNA binding, protection and transfection properties. Colloids Surf A-Biointerfaces, 43, pp. 163-173.
15. Muratovska, A. and Eccles, MR (2004) Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett, 558, pp. 63-68.
16. Naffe, N., Taetz, S., Schneider, M., Schaefer, UF and Lehr, CM (2007) Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: Effect of the formulation parameters on complexation and transfection of antisense oligonucleotides. Nanomedicine, 3, pp. 173-183.
17. Nicol, S. (1991) Life after death for empty shells. New Sci, 129, pp. 46-48.
18. Ravi Kumar, MNV, Bakowsky, U. and Lehr, CM (2004) Preparation and characterization of cationic PLGA nanospheres as DNA carriers. Biomaterials, 25, pp. 1771-1777.
19. Richardson, SCW, Kolbe, HVJ and Duncan, R. (1999) Potential of low molecular mass chitosan as a DNA delivery system: Biocompatibility, body distribution and ability to complex and protect DNA. Int J Pharm, 178, pp. 231-243.
20. Shu, XZ and Zhu, KJ (2002) The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release. Eur J Pharm Biopharm, 54, pp. 235-243.
21. Sioud, M. and Sorensen, DR (2003) Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem Biophys Res Commun, 312, pp. 1220-1225.
22. Taghizadeh, SM and Davari, G. (2006) Preparation, characterization and swelling behaviour of N-acetylated and deacetylated chitosans. Carbohydr Polym, 64, pp. 9-15.