SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis

Molecular and Cellular Endocrinology

Volumn 336, Issue 1-2, 2011, Pages 219-223

  Kim, Ki Woo ^a   Sohn, Jong Woo ^a   Kohno, Daisuke ^a   Xu, Yong ^a   Williams, Kevin ^a   Elmquist, Joel K ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Arcuate nucleus of the hypothalamus (ARH); Diet induced obesity; Dorsomedial hypothalamic nucleus (DMH); Energy homeostasis; Steroidogenic factor 1 (SF 1); Ventral medial nucleus of the hypothalamus (VMH)

Indexed keywords

STEROIDOGENIC FACTOR 1;

BODY WEIGHT; BRAIN DEVELOPMENT; ENERGY BALANCE; FOOD INTAKE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MOLECULAR MECHANICS; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; HOMEOSTASIS; HUMANS; INTEGRASES; LEPTIN; NEURONS; STEROIDOGENIC FACTOR 1; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 79952068857     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2010.11.019     Document Type: Review

References (41)

1. Al-Qassab H., Smith M.A., Irvine E.E., Guillermet-Guibert J., Claret M., Choudhury A.I., Selman C., Piipari K., Clements M., Lingard S., Chandarana K., Bell J.D., Barsh G.S., Smith A.J., Batterham R.L., Ashford M.L., Vanhaesebroeck B., Withers D.J. Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab. 2009, 10:343-354.
2. Balthasar N., Coppari R., McMinn J., Liu S.M., Lee C.E., Tang V., Kenny C.D., McGovern R.A., Chua S.C., Elmquist J.K., Lowell B.B. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 2004, 42:983-991.
3. Bernardis L.L., Frohman L.A. Effects of hypothalamic lesions at different loci on development of hyperinsulinemia and obesity in the weanling rat. J. Comp. Neurol. 1971, 141:107-115.
4. Bingham N.C., Anderson K.K., Reuter A.L., Stallings N.R., Parker K.L. Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 2008, 149:2138-2148.
5. Bingham N.C., Verma-Kurvari S., Parada L.F., Parker K.L. Development of a steroidogenic factor 1/Cre transgenic mouse line. Genesis 2006, 44:419-424.
6. Broberger C., Hokfelt T. Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol. Behav. 2001, 74:669-682.
7. Campfield L.A. Central mechanisms responsible for the actions of OB protein (leptin) on food intake, metabolism and body energy storage. Front. Horm. Res. 2000, 26:12-20.
8. Cohen P., Zhao C., Cai X., Montez J.M., Rohani S.C., Feinstein P., Mombaerts P., Friedman J.M. Selective deletion of leptin receptor in neurons leads to obesity. J. Clin. Invest. 2001, 108:1113-1121.
9. Cox J.E., Powley T.L. Intragastric pair feeding fails to prevent VMH obesity or hyperinsulinemia. Am. J. Physiol. 1981, 240:E566-E572.
10. de Luca C., Kowalski T.J., Zhang Y., Elmquist J.K., Lee C., Kilimann M.W., Ludwig T., Liu S.M., Chua S.C. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J. Clin. Invest. 2005, 115:3484-3493.
11. Dhillon H., Zigman J.M., Ye C., Lee C.E., McGovern R.A., Tang V., Kenny C.D., Christiansen L.M., White R.D., Edelstein E.A., Coppari R., Balthasar N., Cowley M.A., Chua S., Elmquist J.K., Lowell B.B. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 2006, 49:191-203.
12. Elmquist J.K., Ahima R.S., Elias C.F., Flier J.S., Saper C.B. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:741-746.
13. Elmquist J.K., Ahima R.S., Maratos-Flier E., Flier J.S., Saper C.B. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 1997, 138:839-842.
14. Elmquist J.K., Elias C.F., Saper C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 1999, 22:221-232.
15. Heimer L., Nauta W.J. The hypothalamic distribution of the stria terminalis in the rat. Brain Res. 1969, 13:284-297.
16. Hetherington A.W., Ranson S.W. Hypothalamic lesions and adiposity in the rat. Anat. Rec. 1940, 78:149-172.
17. Hill J.W., Williams K.W., Ye C., Luo J., Balthasar N., Coppari R., Cowley M.A., Cantley L.C., Lowell B.B., Elmquist J.K. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J. Clin. Invest. 2008, 118:1796-1805.
18. Ikeda Y., Luo X., Abbud R., Nilson J.H., Parker K.L. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol. Endocrinol. 1995, 9:478-486.
19. Ikeda Y., Nagai A., Ikeda M.A., Hayashi S. Neonatal estrogen exposure inhibits steroidogenesis in the developing rat ovary. Dev. Dyn. 2001, 221:443-453.
20. Inoue S., Campfield L.A., Bray G.A. Comparison of metabolic alterations in hypothalamic and high fat diet-induced obesity. Am. J. Physiol. 1977, 233:R162-R168.
21. Kurrasch D.M., Cheung C.C., Lee F.Y., Tran P.V., Hata K., Ingraham H.A. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J. Neurosci. 2007, 27:13624-13634.
22. Legenbauer T., De Zwaan M., Benecke A., Muhlhans B., Petrak F., Herpertz S. Depression and anxiety: their predictive function for weight loss in obese individuals. Obes. Facts 2009, 2:227-234.
23. Loten E.G., Rabinovitch A., Jeanrenaud B. In vivo studies on lipogenesis in obese hyperglycaemic (ob-ob) mice: possible role of hyperinsulinaemia. Diabetologia 1974, 10:45-52.
24. Lowell B.B., Spiegelman B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 2000, 404:652-660.
25. Majdic G., Young M., Gomez-Sanchez E., Anderson P., Szczepaniak L.S., Dobbins R.L., McGarry J.D., Parker K.L. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 2002, 143:607-614.
26. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 1996, 387:113-116.
27. Morton G.J., Gelling R.W., Niswender K.D., Morrison C.D., Rhodes C.J., Schwartz M.W. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2005, 2:411-420.
28. Niijima A., Rohner-Jeanrenaud F., Jeanrenaud B. Role of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue. Am. J. Physiol. 1984, 247:R650-R654.
29. Niswender K.D., Morton G.J., Stearns W.H., Rhodes C.J., Myers M.G., Schwartz M.W. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001, 413:794-795.
30. Oku J., Bray G.A., Fisler J.S., Schemmel R. Ventromedial hypothalamic knife-cut lesions in rats resistant to dietary obesity. Am. J. Physiol. 1984, 246:R943-948.
31. Parker K.L., Rice D.A., Lala D.S., Ikeda Y., Luo X., Wong M., Bakke M., Zhao L., Frigeri C., Hanley N.A., Stallings N., Schimmer B.P. Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog. Horm. Res. 2002, 57:19-36.
32. Rohner-Jeanrenaud F., Seydoux J., Chinet A., Bas S., Giacobino J.P., Assimacopoulos-Jeannet F., Jeanrenaud B., Girardier L. Defective diet-induced but normal cold-induced brown adipose tissue adaptation in hypothalamic obesity in rats. J. Physiol. (Paris) 1982, 78:833-837.
33. Saper C.B., Chou T.C., Elmquist J.K. The need to feed: homeostatic and hedonic control of eating. Neuron 2002, 36:199-211.
34. Scott M.M., Lachey J.L., Sternson S.M., Lee C.E., Elias C.F., Friedman J.M., Elmquist J.K. Leptin targets in the mouse brain. J. Comp. Neurol. 2009, 514:518-532.
35. Segal J.P., Stallings N.R., Lee C.E., Zhao L., Socci N., Viale A., Harris T.M., Soares M.B., Childs G., Elmquist J.K., Parker K.L., Friedman J.M. Use of laser-capture microdissection for the identification of marker genes for the ventromedial hypothalamic nucleus. J. Neurosci. 2005, 25:4181-4188.
36. Shinoda K., Lei H., Yoshii H., Nomura M., Nagano M., Shiba H., Sasaki H., Osawa Y., Ninomiya Y., Niwa O., et al. Developmental defects of the ventromedial hypothalamic nucleus and pituitary gonadotroph in the Ftz-F1 disrupted mice. Dev. Dyn. 1995, 204:22-29.
37. Tobet S.A., Henderson R.G., Whiting P.J., Sieghart W. Special relationship of gamma-aminobutyric acid to the ventromedial nucleus of the hypothalamus during embryonic development. J. Comp. Neurol. 1999, 405:88-98.
38. Xu Y., Hill J.W., Fukuda M., Gautron L., Sohn J.W., Kim K.W., Lee C.E., Choi M.J., Lauzon D.A., Dhillon H., Lowell B.B., Zigman J.M., Zhao J.J., Elmquist J.K. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010, 12:88-95.
39. Zhang R., Dhillon H., Yin H., Yoshimura A., Lowell B.B., Maratos-Flier E., Flier J.S. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 2008, 149:5654-5661.
40. Zhao A.Z., Huan J.N., Gupta S., Pal R., Sahu A. A phosphatidylinositol 3-kinase phosphodiesterase 3B-cyclic AMP pathway in hypothalamic action of leptin on feeding. Nat. Neurosci. 2002, 5:727-728.
41. Zhao L., Kim K.W., Ikeda Y., Anderson K.K., Beck L., Chase S., Tobet S.A., Parker K.L. Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol. Endocrinol. 2008, 22:1403-1415.