LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions

Journal of Biological Chemistry

Volumn 287, Issue 26, 2012, Pages 22184-22195

  Jepson, Scott ^a   Vought, Bryan ^a   Gross, Christian H ^a   Gan, Lu ^a   Austen, Douglas ^a   Frantz, J Daniel ^a   Zwahlen, Jacque ^a   Lowe, Derek ^a   Markland, William ^a   Krauss, Raul ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AXONAL GROWTH; CHO CELL; CO-CULTURES; DORSAL ROOT GANGLIA; ECTODOMAIN; EXTRACELLULAR SIGNALS; INHIBITORY EFFECT; INTEGRAL COMPONENTS; INTERCELLULAR INTERACTIONS; INTERCELLULAR SIGNALING; LIGAND BINDING; MULTIPLE SCLEROSIS; MYELINATION; NEGATIVE REGULATORS; OLIGODENDROCYTES; OVER-EXPRESSION; PRECURSOR CELLS; PROTEIN-PROTEIN INTERACTIONS; RECEPTOR COMPLEX; REMYELINATION; SELF-ASSOCIATIONS; SELF-INTERACTIONS; SURFACE BOUNDS; TERMINAL DIFFERENTIATION; TRANS-MEMBRANE SIGNALING;

ASSOCIATION REACTIONS; DISEASE CONTROL; LIGANDS; SIGNALING; TISSUE;

PROTEINS;

CELL RECEPTOR; LINGO 1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL INTERACTION; CHO CELL; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; MOUSE; MYELINATION; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; OLIGODENDROGLIA PRECURSOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION;

ANIMALS; ASTROCYTES; AXONS; CELL DIFFERENTIATION; CELL MEMBRANE; CHO CELLS; COCULTURE TECHNIQUES; CRICETINAE; HUMANS; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; MEMBRANE PROTEINS; MICE; MULTIPLE SCLEROSIS; MYELIN SHEATH; NERVE TISSUE PROTEINS; NEUROGLIA; OLIGODENDROGLIA;

EID: 84862667140     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.366179     Document Type: Article

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