IGF-1 protects oligodendrocyte progenitors against TNFα-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway

GLIA

Volumn 55, Issue 11, 2007, Pages 1099-1107

  Pang, Yi ^a   Zheng, Baoying ^a   Fan, Lir Wan ^a   Rhodes, Philip G ^a   Cai, Zhengwei ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspase; Cytokine; ERK; MEK

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BASIC FIBROBLAST GROWTH FACTOR; CASPASE 3; CASPASE 9; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN BAD; PROTEIN BAX; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SOMATOMEDIN C; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEWBORN; NICK END LABELING; NONHUMAN; OLIGODENDROGLIA; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; CASPASES; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CYTOSOL; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; MITOCHONDRIA; OLIGODENDROGLIA; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION; STEM CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34547645231     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20530     Document Type: Article

References (32)

1. Back SA, Luo NL, Mallinson RA, O'Malley JP, Wallen LD, Frei B, Morrow JD, Petito CK, Roberts CT Jr, Murdoch GH, Montine TJ. 2005. Selective vulnerability of preterm white matter to oxidative damage defined by F2-isoprostanes. Ann Neurol 58:108-120.
2. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and independent mechanisms. Science 286:1358-1362.
3. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. 1991. ERKS: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675.
4. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. 96:857-868.
5. Cao Y, Gunn AJ, Bennet L, Wu D, George S, Gluckman PD, Shao XM, Guan J. 2003. Insulin-like growth factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep. J Cereb Blood Flow Metab 23:739-747.
6. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JS. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
7. Chu CT, Levinthal DJ., Kulich SM, Chalovich EM, Defranco DB. 2004. Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem 271:2060-2066.
8. Cui QL, Zheng WH, Quirion R, Almazan G. 2005. Inhibition of Src-like kinases reveals Akt-dependent and -independent pathways in insulin-like growth factor I-mediated oligodendrocyte progenitor survival. J Biol Chem 280:8918-8928.
9. Datta SR, Dudek H, Tal X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
10. Deguchi K, Mizuguchi M, Takashima S. 1996. Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia. Pediatr Neurol 14:13-16.
11. Flores AI, Mallon BS, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB. 2000. Akt-mediated survival of oligodendrocytes induced by neuregulins. J Neurosci 20:7622-7630.
12. Gozdz A, Habas A, Jaworski J, Zielinska M, Albrecht J, Chlystun M, Jalili A, Hetman M. 2003. Role of N-methyl-D-asparate receptors in the neuroprotective activation of extracellular signal-regulated kinase [1/2] by cisplatin. J Biol Chem 278:43663-43671.
13. Jin K, Mao X, Zhu Y, Greenberg DA. 2002. MEK and ERK protect hypoxic cortical neurons via phosphorylation of BAD. J Neurochem 80:119-125.
14. Kooijman R. 2006. Regulation of apoptosis by insulin-like growth factor (IGF)-1. Cytokines Growth Factor Rev 17:305-323.
15. Leinninger GM, Feldman EL. 2005. Insulin-like growth factors in the treatment of neurological disease. Endocr Dev 9:135-159.
16. Li H, Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
17. McLaurin J, D'Souza S, Steward J, Blain M, Beaudet A, Nalbantoglu J, Antel JP. 1995. Effect of tumor necrosis factor α and β on human oligodendrocytes and neurons in culture. Int J Dev Neurosci 13:369-381.
18. McQuillen PS, Ferriero DM. 2004. Selective vulnerability in the developing central nervous system. Pediatr Neurol 30:227-235.
19. Micheau O, Tschopp J. 2003. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190.
20. Ness J, Wood T. 2002. Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis. Mol Cell Neurosci 20:476-488.
21. Ness JK, Scaduto RC Jr., Wood TL. 2004. IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitors. Glia 46:183-194.
22. Palacios N, Sanchez-Franco F, Fernandez M, Sanchez I, Cacicedo L. 2005. Intracellular events mediating insulin-like growth factor I-induced oligodendrocyte development: Modulation by cyclic AMP. J Neurochem 95:1091-1107.
23. Pang Y, Cai Z, Rhodes PG. 2005. Effect of tumor necrosis factor-α on developing optic nerve oligodendrocytes in culture. J Neurosci Res 15:226-234.
24. Runden E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, Laake JH. 1998. Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism. Neurosci 18:7296-7305.
25. Segal RA, Greenberg ME. 1996. Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-489.
26. Varfolomeev EE, Ashkenazi A. 2004. Tumor necrosis factor: An apoptosis JuNKie? Cell 116:491-497.
27. Vincent AM, Feldman EL. 2002. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 12:193-197.
28. Volpe JJ. 2001. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 50:553-562.
29. Volpe JJ. 2003. Cerebral white matter injury of the premature infant-more common than you think. Pediatrics 112:176-180.
30. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ. 2000. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14:2060-2070.
31. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. 1995. Opposing effects of ERK, JNK-p38 MAP kinases on apoptosis. Science 270:1326-31.
32. Ye P, D'Ercole AJ. 1999. Insulin-like growth factor I protects oligodendrocytes from tumor necrosis factor-α-induced injury. Endocrinology 140:3063-3072.