Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) for comparing betalain biosynthesis and antioxidant activity

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 34, 2014, Pages 8764-8771

  Lee, Sarah ^a   Suh, Dong Ho ^a   Lee, Sunmin ^a   Heo, Do Yeon ^a   Kim, Young Suk ^b   Cho, Somi Kim ^c   Lee, Choong Hwan ^a  

^a Konkuk University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Jeju National University   (South Korea)

Author keywords

antioxidant activity; betalain biosynthesis pathway; GC TOF MS; Hylocereus polyrhizus; Hylocereus undatus; metabolite profiling; UPLC Q TOF MS

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; GAS CHROMATOGRAPHY; INDUCTIVELY COUPLED PLASMA; LEAST SQUARES APPROXIMATIONS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MULTIVARIANT ANALYSIS; CHROMATOGRAPHY; SPECTROMETRY;

ANTI-OXIDANT ACTIVITIES; BIOSYNTHESIS PATHWAYS; GC-TOF-MS; HYLOCEREUS POLYRHIZUS; HYLOCEREUS UNDATUS; METABOLITE PROFILING; UPLC Q-TOF MS;

METABOLITES;

HYLOCEREUS POLYRHIZUS; HYLOCEREUS UNDATUS; STENOCEREUS STELLATUS;

ANTIOXIDANT; BETALAIN; FLAVONOID; PLANT EXTRACT; POLYPHENOL;

BIOSYNTHESIS; CACTACEAE; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; FRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLOMICS;

ANTIOXIDANTS; BETALAINS; CACTACEAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; FRUIT; MASS SPECTROMETRY; METABOLOMICS; PLANT EXTRACTS; POLYPHENOLS;

EID: 84906762112     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf5020704     Document Type: Article

References (40)

1. Le Bellec, F.; Vaillant, F.; Imbert, E. Pitahaya (Hylocereus spp.): A new fruit crop, a market with future Fruits 2006, 61, 237-250
2. Moreno, D. A.; García-Viguera, C.; Gil, J. I.; Gil-Izquierdo, A. Betalains in the era of global agri-food science, technology and nutritional health Phytochem. Rev. 2008, 7, 261-280
3. Wybraniec, S.; Stalica, P.; Jerz, G.; Klose, B.; Gebers, N.; Winterhalter, P.; Sporna, A.; Szaleniec, M.; Mizrahi, Y. Separation of polar betalain pigments from cacti fruits of Hylocereus polyrhizus by ion-pair high-speed countercurrent chromatography J. Chromatogr. A 2009, 1216, 6890-6899
4. Strack, D.; Vogt, T.; Schliemann, W. Recent advances in betalain research Phytochemistry 2003, 62, 247-269
5. Vaillant, F.; Perez, A.; Davila, I.; Dornier, M.; Reynes, M. Colorant and antioxidant properties of red-purple pitahaya (Hylocereus sp.) Fruits 2005, 60, 3-12
6. Kim, H.; Choi, H.-K.; Moon, J. Y.; Kim, Y. S.; Mosaddik, A.; Cho, S. K. Comparative antioxidant and antiproliferative activities of red and white pitayas and their correlation with flavonoid and polyphenol content J. Food Sci. 2011, 76, C38-C45
7. Tenore, G. C.; Novelino, E.; Basile, A. Nutraceutical potential and antioxidant benefits of red pitaya (Hylocereus polyrhizus) extracts J. Funct. Foods 2012, 4, 129-136
8. Kapadia, G. J.; Azuine, M. A.; Sridhar, R.; Okuda, Y.; Tsuruta, A.; Ichiishi, E.; Mukainake, T.; Takasaki, M.; Konoshima, T.; Nishino, H.; Tokuda, H. Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot Pharmacol. Res. 2003, 47, 141-148
9. Gentile, C.; Tesoriere, L.; Allegra, M.; Livrea, M. A.; D'Alessio, P. Antioxidant betalains from cactus pear (Opuntia ficus indica) inhibit endothelial ICAM-1 expression Ann. N. Y. Acad. Sci. 2004, 1028, 481-486
10. Katajamaa, M.; Oresic, M. Data processing for mass spectrometry-based metabolomics J. Chromatogr. A 2007, 1158, 318-328
11. Jung, E. S.; Lee, S.; Lim, S.-H.; Ha, S.-H.; Liu, K.-H.; Lee, C. H. Metabolite profiling of the short-term responses of rice leaves (Oryza sativa cv. Ilmi) cultivated under different LED lights and its correlations with antioxidant activities Plant Sci. 2013, 210, 61-69
12. Lee, S.; Do, S. G.; Kim, S. Y.; Kim, J.; Jin, Y.; Lee, C. H. Mass spectrometry-based metabolite profiling and antioxidant activity of Aloe vera (Aloe barbadensis Miller) in different growth stages J. Agric. Food Chem. 2012, 60, 11222-11228
13. Lee, S. Y.; Kim, H. Y.; Lee, S.; Lee, J. M.; Muthaiya, M. J.; Kim, B. S.; Oh, J. Y.; Song, C. K.; Jeon, E. S.; Ryu, H. S.; Lee, C. H. Mass spectrometry-based metabolite profiling and bacterial diversity characterization of Korean traditional meju during fermentation J. Microbiol. Biotechnol. 2012, 22, 1523-1531
14. Dietz, B. M.; Kang, Y. H.; Liu, G.; Eggler, A. L.; Yao, P.; Chadwick, L. R.; Pauli, G. F.; Farnsworth, N. R.; Mesecar, A. D.; van Breemen, R. B.; Bolton, J. L. Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase Chem. Res. Toxicol. 2005, 18, 1296-1305
15. Re, R.; Pellegrini, N.; Proteggente, A.; Pannala, A.; Yang, M.; Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay Free Radical Biol. Med. 1999, 26, 1231-1237
16. Benzie, I. F. F.; Strain, J. J. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": The FRAP assay Anal. Biochem. 1996, 239, 70-76
17. Singleton, V. L.; Orthofer, R.; Lamuela-Raventos, R. M. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent Methods Enzymol. 1999, 299, 152-178
18. Cai, Y.; Sun, M.; Wu, H.; Huang, R.; Corke, H. Characterization and quantification of betacyanin pigments from diverse Amaranthus s pecies J. Agric. Food Chem. 1998, 46, 2063-2070
19. Carrari, F.; Fernie, A. R. Metabolic regulation underlying tomato fruit development J. Exp. Bot. 2006, 57, 1883-1897
20. Etienne, C.; Rothan, C.; Moing, A.; Plomion, C.; Bodénès, C.; Svanella-Dumas, L.; Cosson, P.; Pronier, V.; Monet, R.; Dirlewanger, E. Candidate genes and QTLs for sugar and organic acid content in peach [ Prunus persica (L.) Batsch] Theor. Appl. Genet. 2002, 105, 145-159
21. Gomez, M.; Lajolo, F.; Cordenunsi, B. Evolution of soluble sugars during ripening of papaya fruit and its relation to sweet taste J. Food Sci. 2002, 67, 442-447
22. Kafkas, E.; Kosar, M.; Turemis, N.; Baser, K. H. C. Analysis of sugars, organic acids and vitamin C contents of blackberry genotypes from Turkey Food Chem. 2006, 97, 732-736
23. Ariffin, A. A.; Bakar, J.; Tan, C. P.; Rahman, R. A.; Karim, R.; Loi, C. C. Essential fatty acids of pitaya (dragon fruit) seed oil Food Chem. 2009, 114, 561-564
24. Beare-Rogers, J.; Dieffenbacher, A.; Holm, J. V. Lexicon of lipid nutrition Pure Appl. Chem. 2001, 73, 685-744
25. Moßhammer, M. R.; Rohe, M.; Stintzing, F. C.; Carle, R. Stability of yellow-orange cactus pear (Opuntia ficus-indica, [L.] Mill. Cv. 'Gialla') betalains as affected by the juice matrix and selected food additives Eur. Food Res. Technol. 2007, 225, 21-32
26. Herbach, K. M.; Stintzing, F. C.; Carle, R. Betalain stability and degradation-structural and chromatic aspects J. Food Sci. 2006, 71, R41-R50
27. Wu, L. C.; Hsu, H. W.; Chen, Y. C.; Chiu, C. C.; Lin, Y. I.; Ho, J. A. A. Antioxidant and antiproliferative activities of red pitaya Food Chem. 2006, 95, 319-327
28. Leathers, R. R.; Davin, C.; Zryd, J. P. Betalain producing cell cultures of Beta vulgaris L. var. bikores monogerm (red beet) In Vitro Cell. Dev. Biol. Plant 1992, 28, 39-45
29. Wybraniec, S.; Starzak, K.; Skopinska, A.; Nemzer, B.; Pietrzkowski, Z.; Michałowski, T. Studies on nonenzymatic oxidation mechanisms in neobetanin, betanin, and decarboxylated betanins J. Agric. Food Chem. 2013, 61, 6465-6476
30. Sekiguchi, H.; Ozeki, Y.; Sasaki, N. In vitro synthesis of betaxanthins using recombinant DOPA 4,5-dioxygenase and evaluation of their radical-scavenging activities J. Agric. Food Chem. 2010, 58, 12504-12509
31. Gandía-Herrero, F.; Escribano, J.; García-Carmona, F. Structural implications on color, fluorescence, and antiradical activity in betalains Planta 2010, 232, 449-460
32. Cai, Y.; Sun, M.; Corke, H. Antioxidant activity of betalains from plants of the Amaranthaceae J. Agric. Food Chem. 2003, 51, 2288-2294
33. Gandía-Herrero, F.; García-Carmona, F. Biosynthesis of betalains: Yellow and violet plant pigments Trends Plant Sci. 2013, 18, 334-343
34. Kugler, F.; Graneis, S.; Schreiter, P. P.-Y.; Stintzing, F. C.; Carle, R. Determination of free amino compounds in betalainic fruits and vegetables by gas chromatography with flame ionization and mass spectrometric detection J. Agric. Food Chem. 2006, 54, 4311-4318
35. Kunnika, S.; Pranee, A. Influence of enzyme treatment on bioactive compounds and colour stability of betacyanin in flesh and peel of red dragon fruit Hylocereus polyrhizus (Weber) Britton and Rose Int. Food Res. J. 2011, 18, 1437-1448
36. Kugler, F.; Stintzing, F. C.; Carle, R. Identification of betalains from petioles of differently colored Swiss Chard (Beta vulgaris L. ssp cicla [L.] Alef. Cv. Bright Lights) by high-performance liquid chromatography-electrospray ionization mass spectrometry J. Agric. Food Chem. 2004, 52, 2975-2981
37. Wybraniec, S.; Mizrahi, Y. Generation of decarboxylated and dehydrogenated betacyanins in thermally treated purified fruit extract from purple pitaya (Hylocereus polyrhizus) monitored by LC-MS/MS J. Agric. Food Chem. 2005, 53, 6704-6712
38. Herbach, K. M.; Stintzing, F. C.; Carle, R. Impact of thermal treatment on color and pigment pattern of red beet (Beta vulgaris L.) preparations J. Food Sci. 2004, 69, C491-C498
39. Schliemann, W.; Cai, Y.; Degenkolb, T.; Schmidt, J.; Corke, H. Betalains of Celosia argentea Phytochemistry 2001, 58, 159-165
40. Steiner, U.; Schliemann, W.; Böhm, H.; Strack, D. Tyrosinase involved in betalain biosynthesis of higher plants Planta 1999, 208, 114-124