Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 11, 2008, Pages 2946-2952

  Machida, Kazuhiro ^a   Arisawa, Akira ^a   Takeda, Susumu ^a   Tsuchida, Toshio ^a   Aritoku, Yasuhide ^a   Yoshida, Masashi ^a   Ikeda, Haruo ^b  

^a MERCIAN CORPORATION   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Biosynthetic gene; Cytochrome P450; Pladienolide; Streptomyces platensis

Indexed keywords

ANTIBIOTICS; CLARIFICATION; ENZYMES; GENES; SEWAGE TREATMENT PLANTS;

ANTITUMOR ACTIVITIES; ANTITUMOR AGENTS; BIOSYNTHETIC GENE; BIOSYNTHETIC GENE CLUSTERS; CYTOCHROME P450; DO-MAINS; HYDROXYLASE; MACROLIDE; MACROLIDES; PLADIENOLIDE; PLATENSIS; POLYKETIDE; POLYKETIDE SYNTHASE; POLYKETIDE SYNTHASE GENES; POLYKETIDES; REGULATORY GENES; STREPTOMYCES PLATENSIS; THIOESTERASE;

POLYMERS;

ANTINEOPLASTIC AGENT; EPOXIDE; MACROLIDE; PLADIENOLIDE B;

ARTICLE; CLASSIFICATION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; STREPTOMYCES;

ANTINEOPLASTIC AGENTS; CLONING, MOLECULAR; EPOXY COMPOUNDS; MACROLIDES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES PLATENSIS;

EID: 56749105436     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80425     Document Type: Article

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