Pre-mRNA splicing-modulatory pharmacophores: The total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives

ACS Chemical Biology

Volumn 9, Issue 3, 2014, Pages 643-648

  Lagisetti, Chandraiah ^a   Yermolina, Maria V ^a   Sharma, Lalit Kumar ^a   Palacios, Gustavo ^a   Prigaro, Brett J ^a,b   Webb, Thomas R ^a,c  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b SRI INTERNATIONAL   (United States)

^c LC Vision LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PLADIENOLIDE HERBOXIDIENE DERIVATIVE; TETRAHYDROPYRAN DERIVATIVE; UNCLASSIFIED DRUG; EPOXIDE; FATTY ALCOHOL; HERBOXIDIENE; MACROLIDE; MDM2 PROTEIN, HUMAN; PLADIENOLIDE B; PROTEIN MDM2; PYRAN DERIVATIVE; RNA PRECURSOR;

ARTICLE; CHEMICAL REACTION; CLAISEN REARRANGEMENT; DIELS ALDER REACTION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; FERMENTATION; FERRIER REARRANGEMENT; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; PHARMACOPHORE; PRIORITY JOURNAL; RNA SPLICING; TUMOR CELL LINE; ALTERNATIVE RNA SPLICING; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYCLOADDITION; DRUG DESIGN; DRUG EFFECTS; GENETICS; IC50; SYNTHESIS;

ALTERNATIVE SPLICING; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLOADDITION REACTION; DRUG DESIGN; EPOXY COMPOUNDS; FATTY ALCOHOLS; HUMANS; INHIBITORY CONCENTRATION 50; MACROLIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-MDM2; PYRANS; RNA PRECURSORS;

EID: 84896918727     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400695j     Document Type: Article

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