Rational design, preparation, and characterization of a therapeutic enzyme mutant with improved stability and function for cocaine detoxification

ACS Chemical Biology

Volumn 9, Issue 8, 2014, Pages 1764-1772

  Fang, Lei ^a   Chow, K Martin ^b   Hou, Shurong ^a   Xue, Liu ^a   Chen, Xiabin ^a   Rodgers, David W ^b   Zheng, Fang ^a   Zhan, Chang Guo ^a  

^a University of Kentucky   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE[196-301]; COCAINE; DIMER; MACROGOL; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; DETOXIFICATION; DISULFIDE BOND; DRUG DESIGN; ENZYME MECHANISM; ENZYME STABILITY; HALF LIFE TIME; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; SIMULATION; SINGLE DRUG DOSE; THERMOSTABILITY; X RAY DIFFRACTION; ANIMAL; CATALYSIS; METABOLISM;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; COCAINE; DRUG DESIGN; MICE; MOLECULAR DYNAMICS SIMULATION; MUTATION;

EID: 84906228604     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500257s     Document Type: Article

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