Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity

Molecular Pharmacology

Volumn 75, Issue 2, 2009, Pages 318-323

  Gao, Daquan ^a   Narasimhan, Diwahar L ^b   Macdonald, Joanne ^c   Brim, Remy ^b   Ko, Mei Chuan ^b   Landry, Donald W ^c   Woods, James H ^b   Sunahara, Roger K ^b   Zhan, Chang Guo ^a  

^a University of Kentucky   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; COCAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG INTOXICATION; ENZYME ACTIVITY; ENZYME STABILITY; LD 50; MALE; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; TOXICOKINETICS;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; COCAINE; COCAINE-RELATED DISORDERS; DISEASE MODELS, ANIMAL; DRUG DESIGN; MALE; MICE; OVERDOSE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 59449089478     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.049486     Document Type: Article

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