Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats

Drug and Alcohol Dependence

Volumn 118, Issue 2-3, 2011, Pages 158-165

  Collins, Gregory T ^a   Zaks, Matthew E ^a   Cunningham, Alyssa R ^a   St Clair, Carley ^a   Nichols, Joseph ^a   Narasimhan, Diwahar ^a   Ko, Mei Chuan ^a   Sunahara, Roger K ^a   Woods, James H ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Acute cocaine toxicity; Cardiovascular; Cocaine; Cocaine esterase; Convulsion; Lethality; Rat

Indexed keywords

CARBOXYLESTERASE; COCAINE; MUTANT BACTERIAL COCAINE ESTERASE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; FEMALE; HEART RATE; IN VIVO STUDY; LETHAL DOSE 100; LETHALITY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICOLOGICAL PARAMETERS;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; COCAINE; COCAINE-RELATED DISORDERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; REINFORCEMENT (PSYCHOLOGY); SEIZURES;

BACTERIA (MICROORGANISMS); MACACA MULATTA; MUS; RATTUS;

EID: 80053575770     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.03.015     Document Type: Article

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