Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time

Molecular Pharmacology

Volumn 80, Issue 6, 2011, Pages 1056-1065

  Narasimhan, Diwahar ^a   Collins, Gregory T ^a   Nance, Mark R ^b   Nichols, Joseph ^a   Edwald, Elin ^a   Chan, Jimmy ^a   Ko, Mei Chuan ^a   Woods, James H ^a   Tesmer, John J G ^a,b   Sunahara, Roger K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; COCAINE; DIMER; MACROGOL; POLYETHYLENE; PROTEIN SUBUNIT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR EFFECT; COCAINE DEPENDENCE; CONTROLLED STUDY; CRYSTALLIZATION; DISULFIDE BOND; ENZYME ACTIVE SITE; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MELTING POINT; MOLECULAR INTERACTION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTEIN MODIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; RAT; RHESUS MONKEY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; THERMOSTABILITY; WILD TYPE;

ANIMALS; BACTERIAL PROTEINS; CARBOXYLIC ESTER HYDROLASES; COCAINE; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME STABILITY; MACACA MULATTA; MICE; POLYETHYLENE GLYCOLS; PROTEIN STABILITY; PROTEIN SUBUNITS; RATS; SELF ADMINISTRATION;

EID: 81555195482     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.074997     Document Type: Article

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