Engineering a model protein cavity to catalyze the Kemp elimination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 40, 2012, Pages 16179-16183

  Merski, Matthew ^a   Shoichet, Brian K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Enzyme design; Model cavity

Indexed keywords

ARTICLE; CATALYSIS; ELIMINATION REACTION; ENZYME ACTIVITY; HYDROGEN BOND; HYDROPHOBICITY; KEMP ELIMINATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN STABILITY; REACTION ANALYSIS; REACTION OPTIMIZATION; SUBSTITUTION REACTION;

BACTERIOPHAGE T4; CRYSTALLOGRAPHY; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MURAMIDASE; PROTEIN ENGINEERING; THERMODYNAMICS;

EID: 84867093396     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208076109     Document Type: Article

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