Structural analysis of thermostabilizing mutations of cocaine esterase

Protein Engineering, Design and Selection

Volumn 23, Issue 7, 2010, Pages 537-547

  Narasimhan, Diwahar ^a   Nance, Mark R ^b   Gao, Daquan ^c   Ko, Mei Chuan ^a   MacDonald, Joanne ^d   Tamburi, Patricia ^d   Yoon, Dan ^a   Landry, Donald M ^d   Woods, James H ^a   Zhan, Chang Guo ^c   Tesmer, John J G ^a,b   Sunahara, Roger K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d Howard Hughes Medical Institute   (United States)

Author keywords

cocaine esterase; computational; drug abuse; thermostable

Indexed keywords

COCAINE BINDING; COCAINE ESTERASE; COMPUTATIONAL; COMPUTATIONAL APPROACH; CRYSTALLOGRAPHIC DATA; DOPAMINE TRANSPORTERS; DOPAMINE TRANSPORTS; DRUG ABUSE; ENHANCED STABILITY; IN-VITRO; INTRINSIC EFFECTS; PHYSIOLOGICAL TEMPERATURE; PLAUSIBLE MODEL; SMALL MOLECULES; THERAPEUTIC AGENTS; THERMOSTABLE; WILD TYPES;

BRAIN; STRUCTURAL ANALYSIS; TOXICITY;

ENZYMES;

CARBOXYLESTERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOSE RESPONSE; DRUG ACTIVITY; DRUG HALF LIFE; LETHALITY; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; CARBOXYLIC ESTER HYDROLASES; COCAINE; COCAINE-RELATED DISORDERS; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; ESCHERICHIA COLI; KINETICS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RHODOCOCCUS; TEMPERATURE;

EID: 77955941601     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq025     Document Type: Article

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