Molecular chaperones are nanomachines that catalytically unfold misfolded and alternatively folded proteins

Cellular and Molecular Life Sciences

Volumn 71, Issue 17, 2014, Pages 3311-3325

  Mattoo, Rayees U H ^a   Goloubinoff, Pierre ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Disaggregase; GroEL; Holdase; Hsp110; Hsp40; Hsp70; Polypeptide unfoldase; Translocase

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA CRYSTALLIN; ALPHA SYNUCLEIN; CHAPERONE; CHAPERONIN 60; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 100; HEAT SHOCK PROTEIN 104; HEAT SHOCK PROTEIN 110; HEAT SHOCK PROTEIN 20; HEAT SHOCK PROTEIN 22; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN B2B3; HEAT SHOCK PROTEIN B5; HEAT SHOCK TRANSCRIPTION FACTOR 1; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN CLPB; PROTEIN DNAJ; PROTEIN DNAK; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BINDING AFFINITY; CATALYSIS; CHLOROPLAST; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; MITOCHONDRION; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN UNFOLDING; REVIEW; SIGNAL TRANSDUCTION; STRESS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATALYSIS; ESCHERICHIA COLI PROTEINS; HEAT-SHOCK PROTEINS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; NEURODEGENERATIVE DISEASES; PEPTIDYLPROLYL ISOMERASE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN TRANSPORT; PROTEOSTASIS DEFICIENCIES; STRESS, PHYSIOLOGICAL;

EID: 84906096557     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-014-1627-y     Document Type: Review

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