Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria

Cell

Volumn 87, Issue 1, 1996, Pages 33-41

  Bauer, Matthias F ^a   Sirrenberg, Christian ^a   Neupert, Walter ^a   Brunner, Michael ^a  

^a Physiologisches Institut   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOSENSOR; CONTROLLED STUDY; DIMERIZATION; DISSOCIATION; ELECTRIC POTENTIAL; ESCHERICHIA COLI; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PREDICTION; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE ANALYSIS;

ESCHERICHIA COLI;

EID: 0030272378     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81320-3     Document Type: Article

References (35)

1. Berthold, J., Bauer, M.F., Schneider, H.C., Klaus, C., Dietmeier, K., Neupert, W., and Brunner, M. (1995). The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP driving system. Cell 81, 1085-1093.
2. Blom, J., Dekker, J.T., and Meijer, M. (1996). Functional and physical interactions of components of the yeast mitochondrial inner-membrane import machinery (MIM). Eur. J. Biochem. 232, 309-314.
3. Dekker, P.J.T., Keil, P., Rassow, J., Maarse, A.C., Pfanner, N., and Meijer, M. (1993). Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett. 331, 66-70.
4. Emtage, J.L.T., and Jensen, R.E. (1993). MAS6 encodes an essential inner membrane component of the yeast mitochondrial import pathway. J. Cell Biol. 122, 1003-1012.
5. Friedman, A.M., Fischmann, T.O., and Steitz, T.A. (1995). Crystal structure of lac repressor core tetramer and its implications for DNA looping. Science 268, 1721-1727.
6. Click, B.S. (1995). Can Hsp70 proteins act as force-generating motors? Cell 80, 11-14.
7. Click, B.S., Wachter, C., and Schatz, G. (1991). Protein import into mitochondria: two systems acting in tandem? Trends Cell Biol. 1, 99-103.
8. Hill, J., Donald, K.A.I.G., and Griffith, D.E. (1991). DMSO enhanced whole cell yeast transformation. Nucleic Acids. Res. 19, 5791-5796.
9. Horst, M., Hilfiker-Rothenfluh, S., Oppliger, W., and Schatz, G. (1995). Dynamic interaction of protein translocation systems in the inner and outer membranes of yeast mitochondria. EMBO J. 14, 2293-2297.
10. Hovland P., Flick, J., Johnston, M., and Scalafani, R.A. (1989). Galactose as a gratuitous inducer of gal gene expresson in yeast growing on glucose. Gene 83, 57-64.
11. Hwang, S., Jascur, T., Vestweber, D., Pon, L., and Schatz, G. (1989). Disrupted yeast mitochondria can import precursor proteins directly through their inner membrane. J. Cell Biol. 109, 487-493.
12. Jeffrey, P.D., Gorina, S., and Pavletich, N.P. (1995). Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 Angstroms. Science 267, 1498-1502.
13. Kronidou, N.G., Oppliger, W., Bolliger, L., Hannavy, K., Click, B.S., Schatz, G., and Horst, M. (1994). Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of yeast mitochondrial inner membrane. Proc. Natl. Acad. Sci. USA 91, 12818-12822.
14. Kübrich, M., Keil, P., Rassow, J., Dekker, P.J.T., Blom, J., Meijer, M., and Pfanner, N. (1994). The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site. FEBS Lett. 349, 222-228.
15. Kübrich, M., Dietmeier, K., and Pfanner, N. (1995). Genetic and biochemical dissection of the mitochondrial protein-import machinery. Curr. Genet. 27, 393-403.
16. Lithgow, T., Glick, B.S., and Schatz, G. (1995). The protein import receptor of mitochondria. Trends Biochem. Sci. 20, 98-101.
17. Lupas, A. (1996). Prediction and analysis of coiled-coil structures. Meth. Enzymol. 266, 513-525.
18. Maarse, A.C., Blom, J., Grivell, L.A., and Meijer, M. (1992). MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J. 11, 3619-3628.
19. Maarse, A.C., Blom, J., Keil, P., Pfanner, N., and Meijer, M. (1994). Identification of the essential yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import. FEBS Lett. 349, 215-221.
20. Martin, J., Mahlke, K., and Pfanner, N. (1991). Role of an energized inner membrane in mitochondrial protein import: Δψ drives the movement of presequences. J. Biol. Chem. 266, 18051-18057.
21. Mayer, A., Nargang, F.E., Neupert, W., and Lill, R. (1995a). MOM22 is a receptor for mitochondrial targeting sequences and cooperates with MOM19. EMBO J. 14, 4204-4211.
22. Mayer, A., Neupert, W., and Lill, R. (1995b). Mitochondrial protein import: reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding. Cell 80, 127-137.
23. Pfanner, N., and Neupert, W. (1985). Transport of proteins into mitochondria: a potassium diffusion potential is able to drive the import of ADP/ATP carrier. EMBO J. 4, 2819-2825.
24. Pfanner, N., Rassow, J., van der Klei, I., and Neupert, W. (1992). A dynamic model of the mitochondrial import machinery. Cell 68, 999-1002.
25. Rabindran, S.K., Haroun, R.I., Clos, J., Wisniewski, J., and Wu, C. (1993). Regulation of heat shock factor trimer formation: role of a conserved leucine zipper. Science 259, 230-234.
26. Rassow, J., Maarse, A.C., Krainer, E., Kübrich, M., Müller, H., Meijer, M., Craig, E.A., and Pfanner, N. (1994). Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J. Cell Biol. 127, 1547-1556.
27. Ryan, K.R., and Jensen, R.E. (1993). Mas6p can be cross-linked to an arrested precursor and interacts with other proteins during mitochondrial protein import. J. Biol. Chem. 268, 23743-23746.
28. Ryan, K.R., Menold, M.M., Garrett, S., and Jensen, R.E. (1994). SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol. Biol. Cell 5, 529-538.
29. Schleyer, M., and Neupert, W. (1984). Transport of ADP/ATP carrier into mitochondria. J. Biol. Chem. 259, 3487-3491.
30. Schneider, H.C., Berthold, J., Bauer, M.F., Dietmeier, K., Guiard, B., Brunner, M., and Neupert, W. (1994). Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature 371, 768-774.
31. Stüber, D., Matile, H., and Garotta, G. (1990). System for high-level production in E. coli and rapid purification of recombinant proteins: application to epitope mapping, preparation of antibodies, and structure - function analysis. In Immunological Methods, Vol IV., I. Lefkovits and B. Pernis, eds. (New York: Academic Press, Inc.) pp. 121-152.
32. Ungermann, C., Neupert, W., and Cyr, D.M. (1994). The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science 266, 1250-1253.
33. Ungermann, C., Guiard, B., Neupert, W., and Cyr, D.M. (1996). The Δψ and Hsp70/MIM44 dependent reaction cycle driving early steps of protein import into mitochondria. EMBO J. 15, 735-744.
34. Voos, W., von Ahsen, O., Müller, H., Guiard, B., Rassow, J., and Pfanner, N. (1996). Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins. EMBO J. 15, 2668-2677.
35. Wagner, R.L., Ariletti, J.W., McGrath, M.E., West, B.L., Baxter, J.D., and Fletterick, R.J. (1995). A structural role for hormone in the thyroid hormone receptor. Nature 378, 690-697.