Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

EMBO Journal

Volumn 31, Issue 21, 2012, Pages 4221-4235

  Rampelt, Heike ^a   Kirstein Miles, Janine ^b   Nillegoda, Nadinath B ^a   Chi, Kang ^a   Scholz, Sebastian R ^a   Morimoto, Richard I ^b   Bukau, Bernd ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

chaperones; disaggregation; Hsp110; Hsp70; protein folding

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CELL EXTRACT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK PROTEIN 110; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DISSOLUTION; ENZYME ACTIVITY; HEAT; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIFESPAN; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN HOMEOSTASIS; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING;

ADENOSINE TRIPHOSPHATE; ANIMALS; CAENORHABDITIS ELEGANS; FLUORESCENT ANTIBODY TECHNIQUE; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK RESPONSE; HSP110 HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYDROLYSIS; INCLUSION BODIES; LUCIFERASES; PROTEIN DENATURATION; PROTEIN MULTIMERIZATION; SACCHAROMYCES CEREVISIAE PROTEINS;

CAENORHABDITIS ELEGANS; FUNGI; METAZOA;

EID: 84868525116     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.264     Document Type: Article

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