Enhanced heat shock protein 70 expression alters proteasomal degradation of IκB kinase in experimental acute respiratory distress syndrome

Critical Care Medicine

Volumn 35, Issue 9, 2007, Pages 2128-2138

  Weiss, Yoram G ^a,b   Bromberg, Zohar ^a   Raj, Nichelle ^b   Raphael, Jacob ^a   Goloubinoff, Pierre ^c   Ben Neriah, Yinon ^d   Deutschman, Clifford S ^b  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Acute respiratory distress syndrome; Gene therapy; Heat shock proteins; Lung injury; Proteasomal degradation; Sepsis

Indexed keywords

ADENOVIRUS VECTOR; F BOX PROTEIN; HEAT SHOCK PROTEIN 70; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATE BUFFERED SALINE; PROTEASOME; UBIQUITIN PROTEIN LIGASE; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CECUM; CELL CULTURE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; EPITHELIUM CELL; GEL FILTRATION CHROMATOGRAPHY; GENETIC TRANSFECTION; IN VITRO STUDY; LUNG INJURY; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESPIRATORY DISTRESS; SEPSIS; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; HSP70 HEAT-SHOCK PROTEINS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; NF-KAPPA B; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 34548292474     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000278915.78030.74     Document Type: Article

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