20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol suppresses UV-induced MMP-1 expression through AMPK-mediated mTOR inhibition as a downstream of the PKA-LKB1 pathway

Journal of Cellular Biochemistry

Volumn 115, Issue 10, 2014, Pages 1702-1711

  Shin, Dong Joo ^a   Kim, Jong Eun ^b,c   Lim, Tae Gyu ^b,c   Jeong, Eun Hee ^a   Park, Gaeun ^a   Kang, Nam Joo ^d   Park, Jun Seong ^e   Yeom, Myeong Hun ^e   Oh, Deok Kun ^f   Bode, Ann M ^c   Dong, Zigang ^c   Lee, Hyong Joo ^g   Lee, Ki Won ^a,b,g  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF MINNESOTA   (United States)

^d Kyungpook National University   (South Korea)

^e AmorePacific Corporation   (South Korea)

^f Konkuk University   (South Korea)

^g Seoul National University   (South Korea)

Author keywords

20 O D GLUCOPYRANOSYL 20(S) PROTOPANAXADIOL; AMPK; GINSENOSIDES; MMP 1; mTOR; SKIN AGING; UV

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20 PROTOPANAXADIOL; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERSTITIAL COLLAGENASE; LIVER KINASE B1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTOPANAXADIOL; S6 KINASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; 5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; GINSENOSIDE; GINSENOSIDE M1; ISOQUINOLINE DERIVATIVE; MTOR PROTEIN, HUMAN; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; OXADIN; OXAZINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; RIBONUCLEOTIDE; SMALL INTERFERING RNA; STK11 PROTEIN, HUMAN; SULFONAMIDE; TARGET OF RAPAMYCIN KINASE;

ANTIWRINKLE EFFECT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST; ULTRAVIOLET RADIATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; FIBROBLAST; GENETICS; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE;

AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FIBROBLASTS; GINSENOSIDES; HUMANS; ISOQUINOLINES; MATRIX METALLOPROTEINASE 1; OXAZINES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RIBONUCLEOTIDES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONAMIDES; TOR SERINE-THREONINE KINASES; ULTRAVIOLET RAYS;

EID: 84906090760     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24833     Document Type: Article

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