20-O-β-d-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginseng, inhibits colon cancer growth by targeting TRPC channel-mediated calcium influx

Journal of Nutritional Biochemistry

Volumn 24, Issue 6, 2013, Pages 1096-1104

  Hwang, Jeong Ah ^a   Hwang, Mun Kyung ^a,d   Jang, Yongwoo ^c   Lee, Eun Jung ^a   Kim, Jong Eun ^d   Oh, Mi Hyun ^a   Shin, Dong Joo ^a   Lim, Semi ^a   Ji, Geun og ^c   Oh, Uhtaek ^c   Bode, Ann M ^d   Dong, Zigang ^d   Lee, Ki Won ^a,b   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University   (South Korea)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

20 GPPD; Calcium influx; Colon cancer; TRPC

Indexed keywords

20 O BETA DEXTRO GLUCOPYRANOSYL 20PROTOPANAXADIOL; ADENYLATE KINASE; GINSENOSIDE RB 1; PROTEIN KINASE LKB1; PROTOPANAXADIOL; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; MOUSE; NONHUMAN; POLYMERIZATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CELL DEATH; CELL SURVIVAL; COLONIC NEOPLASMS; FEMALE; GINSENOSIDES; MICE; MICE, INBRED BALB C; PANAX; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRPC CATION CHANNELS;

MURINAE; PANAX GINSENG;

EID: 84878020374     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2012.08.008     Document Type: Article

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