Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf

Biochemical Pharmacology

Volumn 79, Issue 10, 2010, Pages 1455-1461

  Jung, Sung Keun ^a,b,c   Lee, Ki Won ^b,c   Kim, Ho Young ^a,c   Oh, Mi Hyun ^a   Byun, Sanguine ^a,b,c   Lim, Sung Hwan ^a   Heo, Yong Seok ^c   Kang, Nam Joo ^b,c,d   Bode, Ann M ^b   Dong, Zigang ^b   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Konkuk University   (South Korea)

^d Kyungpook National University   (South Korea)

Author keywords

Anti wrinkle; Myricetin; Photoaging; Raf; UVB

Indexed keywords

GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE P38; MYRICETIN; RAF PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PHOTOAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ULTRAVIOLET B RADIATION; WRINKLE;

ANIMALS; BLOTTING, WESTERN; EPIDERMIS; FEMALE; FLAVONOIDS; GENE EXPRESSION; IMMUNOPRECIPITATION; MATRIX METALLOPROTEINASE 9; MICE; MICE, HAIRLESS; MICE, INBRED ICR; RAF KINASES; SKIN AGING; ULTRAVIOLET RAYS;

EID: 77649181352     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.01.004     Document Type: Article

References (43)

1. Sams Jr. W.M., and Smith Jr. J.G. The histochemistry of chronically sun-damaged skin. An investigation of mucopolysaccharides and basophilia in actinically damaged skin using alcian blue, mowry's, and Hicks-Matthaei stains, methylation, and saponification. J Invest Dermatol 37 (1961) 447-453
2. Smith Jr. J.G., Davidson E.A., Sams Jr. W.M., and Clark R.D. Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol 39 (1962) 347-350
3. Gilchrest B.A. A review of skin ageing and its medical therapy. Br J Dermatol 135 (1996) 867-875
4. Grewe M., Trefzer U., Ballhorn A., Gyufko K., Henninger H., and Krutmann J. Analysis of the mechanism of ultraviolet (UV) B radiation-induced prostaglandin E2 synthesis by human epidermoid carcinoma cells. J Invest Dermatol 101 (1993) 528-531
5. Chung J.H., Seo J.Y., Choi H.R., Lee M.K., Youn C.S., Rhie G., et al. Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 117 (2001) 1218-1224
6. Kligman L.H. The hairless mouse model for photoaging. Clin Dermatol 14 (1996) 183-195
7. Kligman L.H. The ultraviolet-irradiated hairless mouse: a model for photoaging. J Am Acad Dermatol 21 (1989) 623-631
8. Fisher G.J., Datta S.C., Talwar H.S., Wang Z.Q., Varani J., Kang S., et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379 (1996) 335-339
9. Fisher G.J., Kang S., Varani J., Bata-Csorgo Z., Wan Y., Datta S., et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138 (2002) 1462-1470
10. Chatterjee R., Benzinger M.J., Ritter J.L., and Bissett D.L. Chronic ultraviolet B radiation-induced biochemical changes in the skin of hairless mice. Photochem Photobiol 51 (1990) 91-97
11. Koivukangas V., Kallioinen M., Autio-Harmainen H., and Oikarinen A. UV irradiation induces the expression of gelatinases in human skin in vivo. Acta Derm Venereol 74 (1994) 279-282
12. Kawaguchi Y., Tanaka H., Okada T., Konishi H., Takahashi M., Ito M., et al. The effects of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts. Arch Dermatol Res 288 (1996) 39-44
13. Kahari V.M., and Saarialho-Kere U. Matrix metalloproteinases in skin. Exp Dermatol 6 (1997) 199-213
14. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol 7 (1995) 728-735
15. Yokoo T., and Kitamura M. Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1. Am J Physiol 270 (1996) F123-F130
16. Zeigler M.E., Chi Y., Schmidt T., and Varani J. Role of ERK and JNK pathways in regulating cell motility and matrix metalloproteinase 9 production in growth factor-stimulated human epidermal keratinocytes. J Cell Physiol 180 (1999) 271-284
17. Moelling K., Heimann B., Beimling P., Rapp U.R., and Sander T. Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature 312 (1984) 558-561
18. Huntington J.T., Shields J.M., Der C.J., Wyatt C.A., Benbow U., Slingluff Jr. C.L., et al. Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. J Biol Chem 279 (2004) 33168-33176
19. Cho H.J., Kang J.H., Kwak J.Y., Lee T.S., Lee I.S., Park N.G., et al. Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. Carcinogenesis 28 (2007) 1104-1110
20. Watanabe H., Shimizu T., Nishihira J., Abe R., Nakayama T., Taniguchi M., et al. Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts. J Biol Chem 279 (2004) 1676-1683
21. Vuorinen H., Maatta K., and Torronen R. Content of the flavonols myricetin, quercetin, and kaempferol in finnish berry wines. J Agric Food Chem 48 (2000) 2675-2680
22. Pastrana-Bonilla E., Akoh C.C., Sellappan S., and Krewer G. Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem 51 (2003) 5497-5503
23. Castillo-Munoz N., Gomez-Alonso S., Garcia-Romero E., and Hermosin-Gutierrez I. Flavonol profiles of Vitis vinifera red grapes and their single-cultivar wines. J Agric Food Chem 55 (2007) 992-1002
24. Mukhtar H., Das M., Khan W.A., Wang Z.Y., Bik D.P., and Bickers D.R. Exceptional activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-nitrosourea-induced skin tumorigenesis in mice. Cancer Res 48 (1988) 2361-2365
25. Aherne S.A., and O'Brien N.M. Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells. Nutr Cancer 34 (1999) 160-166
26. Lee K.M., Kang N.J., Han J.H., Lee K.W., and Lee H.J. Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B. J Agric Food Chem 55 (2007) 9678-9684
27. Ko C.H., Shen S.C., Lee T.J., and Chen Y.C. Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. Mol Cancer Ther 4 (2005) 281-290
28. Sim G.S., Lee B.C., Cho H.S., Lee J.W., Kim J.H., Lee D.H., et al. Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast. Arch Pharm Res 30 (2007) 290-298
29. Jung S.K., Lee K.W., Byun S., Kang N.J., Lim S.H., Heo Y.S., et al. Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Res 68 (2008) 6021-6029
30. Lee K.W., Kang N.J., Rogozin E.A., Kim H.G., Cho Y.Y., Bode A.M., et al. Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis 28 (2007) 1918-1927
31. Vayalil P.K., Mittal A., Hara Y., Elmets C.A., and Katiyar S.K. Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol 122 (2004) 1480-1487
32. Kim H.H., Cho S., Lee S., Kim K.H., Cho K.H., Eun H.C., et al. Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res 47 (2006) 921-930
33. Lin C.C., Tseng H.W., Hsieh H.L., Lee C.W., Wu C.Y., Cheng C.Y., et al. Tumor necrosis factor-alpha induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-kappaB in A549 cells. Toxicol Appl Pharmacol 229 (2008) 386-398
34. Uitto J., Fazio M.J., and Olsen D.R. Molecular mechanisms of cutaneous aging. Age-associated connective tissue alterations in the dermis. J Am Acad Dermatol 21 (1989) 614-622
35. Kim H.H., Shin C.M., Park C.H., Kim K.H., Cho K.H., Eun H.C., et al. Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts. J Lipid Res 46 (2005) 1712-1720
36. Lee K.W., Kang N.J., Heo Y.S., Rogozin E.A., Pugliese A., Hwang M.K., et al. Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine. Cancer Res 68 (2008) 946-955
37. Chung L., Dinakarpandian D., Yoshida N., Lauer-Fields J.L., Fields G.B., Visse R., et al. Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J 23 (2004) 3020-3030
38. Amano S., Ogura Y., Akutsu N., Matsunaga Y., Kadoya K., Adachi E., et al. Protective effect of matrix metalloproteinase inhibitors against epidermal basement membrane damage: skin equivalents partially mimic photoageing process. Br J Dermatol 153 Suppl. 2 (2005) 37-46
39. Seltzer J.L., Eisen A.Z., Bauer E.A., Morris N.P., Glanville R.W., and Burgeson R.E. Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin. J Biol Chem 264 (1989) 3822-3826
40. Aimes R.T., and Quigley J.P. Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments. J Biol Chem 270 (1995) 5872-5876
41. Inomata S., Matsunaga Y., Amano S., Takada K., Kobayashi K., Tsunenaga M., et al. Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol 120 (2003) 128-134
42. Fisher G.J., Talwar H.S., Lin J., Lin P., McPhillips F., Wang Z., et al. Retinoic acid inhibits induction of c-Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest 101 (1998) 1432-1440
43. Wan P.T., Garnett M.J., Roe S.M., Lee S., Niculescu-Duvaz D., Good V.M., et al. Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116 (2004) 855-867