-
1
-
-
79960928267
-
Phosphodiesterase inhibitors in the treatment of inflammatory diseases
-
Page CP, Spina D. Phosphodiesterase inhibitors in the treatment of inflammatory diseases. Handb Exp Pharmacol 2011;204:391-414
-
(2011)
Handb Exp Pharmacol
, vol.204
, pp. 391-414
-
-
Page, C.P.1
Spina, D.2
-
2
-
-
33644811309
-
Phosphodiesterase inhibitors in airways disease
-
Chung KF. Phosphodiesterase inhibitors in airways disease. Eur J Pharmacol 2006;533:110-17
-
(2006)
Eur J Pharmacol
, vol.533
, pp. 110-117
-
-
Chung, K.F.1
-
3
-
-
84906450812
-
Phosphodiesterases
-
In: Taylor JB Triggle DJ editors Elsevier, Oxford, UK
-
Rotella DP. Phosphodiesterases. In: Taylor JB, Triggle DJ, editors. Comprehensive medicinal chemistry II. Elsevier, Oxford, UK; 2007. p. 919-57
-
(2007)
Comprehensive Medicinal Chemistry I.I.
, pp. 919-957
-
-
Rotella, D.P.1
-
4
-
-
84862290893
-
Selective PDE inhibitors as novel treatments for respiratory diseases
-
Page CP, Spina D, Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol 2012;12:275-86
-
(2012)
Curr Opin Pharmacol
, vol.12
, pp. 275-286
-
-
Page, C.P.1
Spina, D.2
-
5
-
-
78649829956
-
Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma
-
e12
-
Jin SL, Goya S, Nakae S, et al. Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 2010;126:1252-9.e12
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 1252-1259
-
-
Jin, S.L.1
Goya, S.2
Nakae, S.3
-
6
-
-
0344513958
-
Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease
-
Spina D. Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease. Drugs 2003;63:2575-94
-
(2003)
Drugs
, vol.63
, pp. 2575-2594
-
-
Spina, D.1
-
7
-
-
0031601540
-
The role of phosphodiesterase enzymes in allergy and asthma
-
Spina D, Landells LJ, Page CP. The role of phosphodiesterase enzymes in allergy and asthma. Adv Pharmacol 1998;44:33-89
-
(1998)
Adv Pharmacol
, vol.44
, pp. 33-89
-
-
Spina, D.1
Landells, L.J.2
Page, C.P.3
-
8
-
-
84883537262
-
Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: Asthma versus controls
-
Yick CY, Zwinderman AH, Kunst PW, et al. Transcriptome sequencing (RNA-Seq) of human endobronchial biopsies: Asthma versus controls. Eur Respir J 2013;42:662-70
-
(2013)
Eur Respir J
, vol.42
, pp. 662-670
-
-
Yick, C.Y.1
Zwinderman, A.H.2
Kunst, P.W.3
-
9
-
-
0037443097
-
PDE4 cAMP phosphodiesterase: Modular enzymes that orchestrate signalling cross-Talk, desensitization and compartmentalization
-
Houslay MD, Adams DR. PDE4 cAMP phosphodiesterase: Modular enzymes that orchestrate signalling cross-Talk, desensitization and compartmentalization. Biochem J 2003;370:1-18
-
(2003)
Biochem J
, vol.370
, pp. 1-18
-
-
Houslay, M.D.1
Adams, D.R.2
-
11
-
-
79956124769
-
Beta2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
-
Trian T, Burgess JK, Niimi K, et al. Beta2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. PLoS One 2011;6:e20000
-
(2011)
PLoS One
, vol.6
-
-
Trian, T.1
Burgess, J.K.2
Niimi, K.3
-
12
-
-
0031914520
-
Phosphodiesterase isoenzymes-molecular targets for novel anti-Asthma agents
-
Torphy TJ. Phosphodiesterase isoenzymes-molecular targets for novel anti-Asthma agents. Am J Respir Crit Care Med 1998;157:351-70
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 351-370
-
-
Torphy, T.J.1
-
14
-
-
84860328659
-
Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma
-
Chevalier E, Lagente V, Dupont M, et al. Lack of involvement of type 7 phosphodiesterase in an experimental model of asthma. Eur Respir J 2012;39:582-8
-
(2012)
Eur Respir J
, vol.39
, pp. 582-588
-
-
Chevalier, E.1
Lagente, V.2
Dupont, M.3
-
15
-
-
31144433061
-
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
-
Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol Ther 2006;109:366-98
-
(2006)
Pharmacol Ther
, vol.109
, pp. 366-398
-
-
Lugnier, C.1
-
16
-
-
0035204531
-
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family
-
Shakur Y, Holst LS, Landstrom TR, et al. Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family. Prog Nucleic Acid Res Mol Biol 2001;66:241-77
-
(2001)
Prog Nucleic Acid Res Mol Biol
, vol.66
, pp. 241-277
-
-
Shakur, Y.1
Holst, L.S.2
Landstrom, T.R.3
-
17
-
-
0028949423
-
Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
-
Reinhardt RR, Chin E, Zhou J, et al. Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases. J Clin Invest 1995;95:1528-38
-
(1995)
J Clin Invest
, vol.95
, pp. 1528-1538
-
-
Reinhardt, R.R.1
Chin, E.2
Zhou, J.3
-
18
-
-
0042355363
-
Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system
-
Maurice DH, Palmer D, Tilley DG, et al. Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system. Mol Pharmacol 2003;64:533-46
-
(2003)
Mol Pharmacol
, vol.64
, pp. 533-546
-
-
Maurice, D.H.1
Palmer, D.2
Tilley, D.G.3
-
19
-
-
60249089353
-
ABCD of the phosphodiesterase family: Interaction and differential activity in COPD
-
Halpin DM. ABCD of the phosphodiesterase family: Interaction and differential activity in COPD. Int J Chron Obstruct Pulmon Dis 2008;3:543-61
-
(2008)
Int J Chron Obstruct Pulmon Dis
, vol.3
, pp. 543-561
-
-
Halpin, D.M.1
-
20
-
-
0037741441
-
Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension
-
Sebkhi A, Strange JW, Phillips SC, et al. Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. Circulation 2003;107:3230-5
-
(2003)
Circulation
, vol.107
, pp. 3230-3235
-
-
Sebkhi, A.1
Strange, J.W.2
Phillips, S.C.3
-
21
-
-
0029075880
-
The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity
-
Barnett MS, Manning CD, Cieslinski LB, et al. The ability of phosphodiesterase IV inhibitors to suppress superoxide production in guinea pig eosinophils is correlated with inhibition of phosphodiesterase IV catalytic activity. J Pharmacol Exp Ther 1995;273:674-9
-
(1995)
J Pharmacol Exp Ther
, vol.273
, pp. 674-679
-
-
Barnett, M.S.1
Manning, C.D.2
Cieslinski, L.B.3
-
22
-
-
0030795747
-
Inhibition of eotaxin-mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram
-
Santamaria LF, Palacios JM, Beleta J. Inhibition of eotaxin-mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram. Br J Pharmacol 1997;121:1150-4
-
(1997)
Br J Pharmacol
, vol.121
, pp. 1150-1154
-
-
Santamaria, L.F.1
Palacios, J.M.2
Beleta, J.3
-
23
-
-
0034024182
-
Phosphodiesterase 4 inhibitors and the treatment of asthma: Where are we now and where do we go from here?
-
Giembycz MA. Phosphodiesterase 4 inhibitors and the treatment of asthma: Where are we now and where do we go from here? Drugs 2000;59:193-212
-
(2000)
Drugs
, vol.59
, pp. 193-212
-
-
Giembycz, M.A.1
-
24
-
-
52949114949
-
Insights into the physiological functions of PDE4 from knockout mice
-
In: Beavo JA Francis SH Houslay MD editors CRC Press, Boca Raton, USA
-
Jin SL, Richter W, Conti M. Insights into the physiological functions of PDE4 from knockout mice. In: Beavo JA, Francis SH, Houslay MD, editors. Cyclic nucleotide phosphodiesterases in health and disease. CRC Press, Boca Raton, USA; 2007. p. 323-46
-
(2007)
Cyclic Nucleotide Phosphodiesterases in Health and Disease
, pp. 323-346
-
-
Jin, S.L.1
Richter, W.2
Conti, M.3
-
25
-
-
0000951113
-
SB207499 (Ariflo), a second generation, selective oral phosphodiesterase type 4 (PDE4) inhibitor, attenuates exercise induced bronchoconstriction in patients with asthma (abstract
-
Nieman RB, Fisher BD, Amit O, Dochorn RG. SB207499 (Ariflo), a second generation, selective oral phosphodiesterase type 4 (PDE4) inhibitor, attenuates exercise induced bronchoconstriction in patients with asthma (abstract). Am J Respir Crit Care Med 1998;157:A413
-
(1998)
Am J Respir Crit Care Med
, vol.157
-
-
Nieman, R.B.1
Fisher, B.D.2
Amit, O.3
Dochorn, R.G.4
-
26
-
-
0000041476
-
Ariflo efficacy in a 12 month study of patients with asthma (abstract
-
Compton C, Duggan M, Cedar E, et al. Ariflo efficacy in a 12 month study of patients with asthma (abstract). Am J Respir Crit Care Med 2000;161:A505
-
(2000)
Am J Respir Crit Care Med
, vol.161
-
-
Compton, C.1
Duggan, M.2
Cedar, E.3
-
27
-
-
0036179542
-
The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exerciseinduced asthma and leads to suppression of LPS-stimulated TNF-Alpha ex vivo
-
Timmer W, Leclerc V, Birraux G, et al. The new phosphodiesterase 4 inhibitor roflumilast is efficacious in exerciseinduced asthma and leads to suppression of LPS-stimulated TNF-Alpha ex vivo. J Clin Pharmacol 2002;42:297-303
-
(2002)
J Clin Pharmacol
, vol.42
, pp. 297-303
-
-
Timmer, W.1
Leclerc, V.2
Birraux, G.3
-
28
-
-
81355154616
-
Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
-
Gauvreau GM, Boulet LP, Schmid-Wirlitsch C, et al. Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects. Respir Res 2011;12:140
-
(2011)
Respir Res
, vol.12
, pp. 140
-
-
Gauvreau, G.M.1
Boulet, L.P.2
Schmid-Wirlitsch, C.3
-
29
-
-
23244467556
-
Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions
-
Van Schalkwyk E, Strydom K, Williams Z, et al. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol 2005;116:292-8
-
(2005)
J Allergy Clin Immunol
, vol.116
, pp. 292-298
-
-
Van Schalkwyk, E.1
Strydom, K.2
Williams, Z.3
-
31
-
-
33644904643
-
Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma
-
Bousquet J, Aubier M, Sastre J, et al. Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma. Allergy 2006;61:72-8
-
(2006)
Allergy
, vol.61
, pp. 72-78
-
-
Bousquet, J.1
Aubier, M.2
Sastre, J.3
-
32
-
-
0029833842
-
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2
-
Giembycz MA, Corrigan CJ, Seybold J, et al. Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2. Br J Pharmacol 1996;118:1945-58
-
(1996)
Br J Pharmacol
, vol.118
, pp. 1945-1958
-
-
Giembycz, M.A.1
Corrigan, C.J.2
Seybold, J.3
-
33
-
-
34447503197
-
Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs
-
Fujimura M, Liu Q. Selective inhibitors for phosphodiesterase 3 and 4 in antigen-induced increase of cough reflex sensitivity in guinea pigs. Pulm Pharmacol Ther 2007;20:543-8
-
(2007)
Pulm Pharmacol Ther
, vol.20
, pp. 543-548
-
-
Fujimura, M.1
Liu, Q.2
-
34
-
-
0031885147
-
Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen
-
Bardin PG, Doward MA, Lampe FC, et al. Effect of selective phosphodiesterase 3 inhibition on the early and late asthmatic responses to inhaled allergen. Br J Clin Pharmacol 1998;45:387-91
-
(1998)
Br J Clin Pharmacol
, vol.45
, pp. 387-391
-
-
Bardin, P.G.1
Doward, M.A.2
Lampe, F.C.3
-
35
-
-
0038408570
-
Bronchodilator effects of intravenous olprinone, a phosphodiesterase 3 inhibitor, with and without aminophylline in asthmatic patients
-
Myou S, Fujimura M, Kamio Y, et al. Bronchodilator effects of intravenous olprinone, a phosphodiesterase 3 inhibitor, with and without aminophylline in asthmatic patients. Br J Clin Pharmacol 2003;55:341-6
-
(2003)
Br J Clin Pharmacol
, vol.55
, pp. 341-346
-
-
Myou, S.1
Fujimura, M.2
Kamio, Y.3
-
36
-
-
0032845131
-
Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients
-
Myou S, Fujimura M, Kamio Y, et al. Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patients. Am J Respir Crit Care Med 1999;160:817-20
-
(1999)
Am J Respir Crit Care Med
, vol.160
, pp. 817-820
-
-
Myou, S.1
Fujimura, M.2
Kamio, Y.3
-
37
-
-
33751043887
-
Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD
-
Jones NA, Leport M, Holand T, et al. Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. Pulm Pharmacol Ther 2007;20:60-8
-
(2007)
Pulm Pharmacol Ther
, vol.20
, pp. 60-68
-
-
Jones, N.A.1
Leport, M.2
Holand, T.3
-
38
-
-
84891658724
-
Selective inhibition of phosphodiesterase 7 (PDE7) by BRL50481 in healthy and ovalbumin-sensitized guinea pigs
-
Christensen I, Miskovicova H, Porvaznik I, et al. Selective inhibition of phosphodiesterase 7 (PDE7) by BRL50481 in healthy and ovalbumin-sensitized guinea pigs. Acta Medica Martiniana 2012;12(Suppl 1):16-23
-
(2012)
Acta Medica Martiniana
, vol.12
, Issue.SUPPL. 1
, pp. 16-23
-
-
Christensen, I.1
Miskovicova, H.2
Porvaznik, I.3
-
39
-
-
84877940204
-
New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders
-
Safavi M, Baeeri M, Abdollahi M. New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders. Expert Opin Drug Discov 2013;8:733-51
-
(2013)
Expert Opin Drug Discov
, vol.8
, pp. 733-751
-
-
Safavi, M.1
Baeeri, M.2
Abdollahi, M.3
-
40
-
-
9444228283
-
Discovery of BRL. 50481 [3-(N, N-dimethylsulfonamido)-4- methylnitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes
-
Smith SJ, Cieslinski LB, Newton R, et al. Discovery of BRL. 50481 [3-(N, N-dimethylsulfonamido)-4-methylnitrobenzene], a selective inhibitor of phosphodiesterase 7: In vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. Mol Pharmacol 2004;66:1679-89
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1679-1689
-
-
Smith, S.J.1
Cieslinski, L.B.2
Newton, R.3
-
41
-
-
70249093993
-
A multi-Target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice
-
Fortin M, DAnjou H, Higgins ME, et al. A multi-Target antisense approach against PDE4 and PDE7 reduces smoke-induced lung inflammation in mice. Respir Res 2009;10:39
-
(2009)
Respir Res
, vol.10
, pp. 39
-
-
Fortin, M.1
Danjou, H.2
Higgins, M.E.3
-
43
-
-
0032804309
-
Experimental studies on guanosine 3,5-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs
-
Kapui Z, Schaeffer P, Mikus EG, et al. Experimental studies on guanosine 3,5-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. Arzneimittelforschung 1999;49:685-93
-
(1999)
Arzneimittelforschung
, vol.49
, pp. 685-693
-
-
Kapui, Z.1
Schaeffer, P.2
Mikus, E.G.3
-
44
-
-
1642493925
-
Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease
-
Toward TJ, Smith N, Broadley KJ. Effect of phosphodiesterase-5 inhibitor, sildenafil (Viagra), in animal models of airways disease. Am J Respir Crit Care Med 2004;169:227-34
-
(2004)
Am J Respir Crit Care Med
, vol.169
, pp. 227-234
-
-
Toward, T.J.1
Smith, N.2
Broadley, K.J.3
-
45
-
-
66749145510
-
Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats
-
Wang T, Liu Y, Chen L, et al. Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats. Eur Respir J 2009;33:1122-32
-
(2009)
Eur Respir J
, vol.33
, pp. 1122-1132
-
-
Wang, T.1
Liu, Y.2
Chen, L.3
-
46
-
-
70350345805
-
Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease
-
Banner KH, Press NJ. Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease. Br J Pharmacol 2009;157:892-906
-
(2009)
Br J Pharmacol
, vol.157
, pp. 892-906
-
-
Banner, K.H.1
Press, N.J.2
-
48
-
-
59349115144
-
Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma
-
Lu S, Liu N, Dass SB, et al. Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med 2009;103:342-7
-
(2009)
Respir Med
, vol.103
, pp. 342-347
-
-
Lu, S.1
Liu, N.2
Dass, S.B.3
-
49
-
-
84880662137
-
Phosphodiesterase-4 inhibitors: A review of current developments (2010-2012)
-
Gavaldà A, Roberts RS. Phosphodiesterase-4 inhibitors: A review of current developments (2010-2012). Expert Opin Ther Pat 2013;23:997-1016
-
(2013)
Expert Opin Ther Pat
, vol.23
, pp. 997-1016
-
-
Gavaldà, A.1
Roberts, R.S.2
-
50
-
-
79955803729
-
Anti-Asthmatic effect of ASP3258, a novel phosphodiesterase 4 inhibitor
-
Kobayashi M, Kubo S, Iwata M, et al. Anti-Asthmatic effect of ASP3258, a novel phosphodiesterase 4 inhibitor. Int Immunopharmacol 2011;11:732-9
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 732-739
-
-
Kobayashi, M.1
Kubo, S.2
Iwata, M.3
-
51
-
-
79953687195
-
Pharmacology of SCH900182, a potent, selective inhibitor of PDE4 for inhaled administration (Abstract
-
Chapman RW, House A, Richard J, et al. Pharmacology of SCH900182, a potent, selective inhibitor of PDE4 for inhaled administration (Abstract). Am J Respir Crit Care Med 2010;181:A5671
-
(2010)
Am J Respir Crit Care Med
, vol.181
-
-
Chapman, R.W.1
House, A.2
Richard, J.3
-
52
-
-
84861341040
-
Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumininduced asthma murine model
-
Kwak HJ, Nam JY, Song JS, et al. Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumininduced asthma murine model. Eur J Pharmacol 2012;685:141-8
-
(2012)
Eur J Pharmacol
, vol.685
, pp. 141-148
-
-
Kwak, H.J.1
Nam, J.Y.2
Song, J.S.3
-
53
-
-
80053374565
-
NCS 613, a potent and specific PDE4 inhibitor, displays antiinflammatory effects on human lung tissues
-
Yougbare I, Morin C, Senouvo FY, et al. NCS 613, a potent and specific PDE4 inhibitor, displays antiinflammatory effects on human lung tissues. Am J Physiol Lung Cell Mol Physiol 2011;301:L441-50
-
(2011)
Am J Physiol Lung Cell Mol Physiol
, vol.301
-
-
Yougbare, I.1
Morin, C.2
Senouvo, F.Y.3
-
54
-
-
84906052660
-
-
Available from Last accessed 13 March 2014]
-
Anonymous Glenmark Pharmaceuticals (Q4 FY13). Available from: Http://m.indiainfoline.com/newsdetail/ResearchNews/Glenmark-Pharmaceuticals-Q4- FY13/42936817 [Last accessed 13 March 2014]
-
Anonymous Glenmark Pharmaceuticals (Q4 FY13)
-
-
-
55
-
-
84906068720
-
The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen-induced responses in mild asthma (abstract
-
Leaker BR, Singh D, Barnes PJ, et al. The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen-induced responses in mild asthma (abstract). Am J Respir Crit Care Med 2010;181:A5613
-
(2010)
Am J Respir Crit Care Med
, vol.181
-
-
Leaker, B.R.1
Singh, D.2
Barnes, P.J.3
-
56
-
-
79953012235
-
In vivo characterization of GSK256066, a high-Affinity inhaled phosphodiesterase 4 inhibitor
-
Nials AT, Tralau-Stewart CJ, Gascoigne MH, et al. In vivo characterization of GSK256066, a high-Affinity inhaled phosphodiesterase 4 inhibitor. J Pharmacol Exp Ther 2011;337:137-44
-
(2011)
J Pharmacol Exp Ther
, vol.337
, pp. 137-144
-
-
Nials, A.T.1
Tralau-Stewart, C.J.2
Gascoigne, M.H.3
-
57
-
-
77952491177
-
The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma
-
Singh D, Petavy F, Macdonald AJ, et al. The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma. Respir Res 2010;11:26
-
(2010)
Respir Res
, vol.11
, pp. 26
-
-
Singh, D.1
Petavy, F.2
MacDonald, A.J.3
-
58
-
-
84897436615
-
-
GlaxoSmithKline February 2013. Available from Last accessed 14 March 2014]
-
GlaxoSmithKline. Product development pipeline 2013. February 2013. Available from: Http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK% 202013%20Pipeline.pdf [Last accessed 14 March 2014]
-
Product Development Pipeline 2013
-
-
-
60
-
-
84905667274
-
Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease
-
Epub ahead of print]
-
Page C, Cazzola M. Bifunctional drugs for the treatment of asthma and chronic obstructive pulmonary disease. Eur Respir J 2014. [Epub ahead of print]
-
(2014)
Eur Respir J
-
-
Page, C.1
Cazzola, M.2
-
61
-
-
84870991478
-
Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration
-
Ochiai K, Takita S, Kojima A, et al. Phosphodiesterase inhibitors. Part 5: Hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration. Bioorg Med Chem Lett 2013;23:375-81
-
(2013)
Bioorg Med Chem Lett
, vol.23
, pp. 375-381
-
-
Ochiai, K.1
Takita, S.2
Kojima, A.3
-
62
-
-
0026072848
-
Effect of oral milrinone on mortality in severe chronic heart failure the PROMISE Study Research Group
-
Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 1991;325:1468-75
-
(1991)
N Engl J Med
, vol.325
, pp. 1468-1475
-
-
Packer, M.1
Carver, J.R.2
Rodeheffer, R.J.3
-
63
-
-
0029067986
-
Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction
-
Ukena D, Rentz K, Reiber C, Sybrecht GW. Effects of the mixed phosphodiesterase III/IV inhibitor, zardaverine, on airway function in patients with chronic airflow obstruction. Respir Med 1995;89:441-4
-
(1995)
Respir Med
, vol.89
, pp. 441-444
-
-
Ukena, D.1
Rentz, K.2
Reiber, C.3
Sybrecht, G.W.4
-
64
-
-
79956098321
-
PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease
-
Diamant Z, Spina D. PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease. Pulm Pharmacol Ther 2011;24:353-60
-
(2011)
Pulm Pharmacol Ther
, vol.24
, pp. 353-360
-
-
Diamant, Z.1
Spina, D.2
-
65
-
-
33745939122
-
The pharmacology of two novel longacting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2, 4,6-Trimethylphenylimino)-3-(n- carbamoyl-2-Aminoethyl)-3,4,6, 7-Tetrahydro-2Hpyrimido[ 6,1-A]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4Hpyrimido[6, 1-A]isoquino lin-4-one]
-
Boswell-Smith V, Spina D, Oxford AW, et al. The pharmacology of two novel longacting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6- Trimethylphenylimino)-3-(n-carbamoyl-2-Aminoethyl)-3,4,6, 7-Tetrahydro- 2Hpyrimido[ 6,1-A]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6- diisopropylphenoxy)-9,10-dimethoxy-4Hpyrimido[6,1-A]isoquino lin-4-one].J Pharmacol Exp Ther 2006;318:840-8
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 840-848
-
-
Boswell-Smith, V.1
Spina, D.2
Oxford, A.W.3
-
66
-
-
84887115924
-
Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: Findings from four clinical trials
-
Franciosi LG, Diamant Z, Banner KH, et al. Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: Findings from four clinical trials. Lancet Respir Med 2013;1:714-27
-
(2013)
Lancet Respir Med
, vol.1
, pp. 714-727
-
-
Franciosi, L.G.1
Diamant, Z.2
Banner, K.H.3
-
67
-
-
84906057946
-
A combined phase I/IIa study of the safety, bronchodilator and bronchoprotective effects of nebulized RPL554, a dual PDE3/4-inhibitor, in healthy subjects and asthmatics (abstract
-
Franciosi L, Diamant Z, Morelli N, et al. A combined phase I/IIa study of the safety, bronchodilator and bronchoprotective effects of nebulized RPL554, a dual PDE3/4-inhibitor, in healthy subjects and asthmatics (abstract). Clin Transl Allergy 2013;3(Suppl 1):O13
-
(2013)
Clin Transl Allergy
, vol.3
, Issue.SUPPL. 1
-
-
Franciosi, L.1
Diamant, Z.2
Morelli, N.3
-
68
-
-
52949140176
-
PDE4 inhibitors: Current status
-
Spina D. PDE4 inhibitors: Current status. Br J Pharmacol 2008;155:308-15
-
(2008)
Br J Pharmacol
, vol.155
, pp. 308-315
-
-
Spina, D.1
-
69
-
-
0034944944
-
Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects
-
Landells LJ, Szilagy CM, Jones NA, et al. Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. Br J Pharmacol 2001;133:722-9
-
(2001)
Br J Pharmacol
, vol.133
, pp. 722-729
-
-
Landells, L.J.1
Szilagy, C.M.2
Jones, N.A.3
-
70
-
-
18744393466
-
Life after PDE4: Overcoming adverse events with dualspecificity phosphodiesterase inhibitors
-
Giembycz MA. Life after PDE4: Overcoming adverse events with dualspecificity phosphodiesterase inhibitors. Curr Opin Pharmacol 2005;5:238-44
-
(2005)
Curr Opin Pharmacol
, vol.5
, pp. 238-244
-
-
Giembycz, M.A.1
-
71
-
-
84897959610
-
Dual PDE3/4 and PDE4 inhibitors: Novel treatments for COPD and other inflammatory airway diseases
-
Banner KH, Page CP. Dual PDE3/4 and PDE4 inhibitors: Novel treatments for COPD and other inflammatory airway diseases. Basic Clin Pharmacol Toxicol 2014;114(5):365-76
-
(2014)
Basic Clin Pharmacol Toxicol
, vol.114
, Issue.5
, pp. 365-376
-
-
Banner, K.H.1
Page, C.P.2
-
72
-
-
0036795111
-
Analysis of induced sputum in adults with asthma: Identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
-
Green RH, Brightling CE, Woltmann G, et al. Analysis of induced sputum in adults with asthma: Identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002;57:875-9.
-
(2002)
Thorax
, vol.57
, pp. 875-879
-
-
Green, R.H.1
Brightling, C.E.2
Woltmann, G.3
|