Roflumilast attenuates allergen-induced inflammation in mild asthmatic subjects

Respiratory Research

Volumn 12, Issue , 2011, Pages

  Gauvreau, Gail M ^a   Boulet, Louis Philippe ^b   Schmid Wirlitsch, Christine ^c   Côté, Johanne ^b   Duong, MyLinh ^a   Killian, Kieran J ^a   Milot, Joanne ^b   Deschesnes, Francine ^b   Strinich, Tara ^a   Watson, Richard M ^a   Bredenbröker, Dirk ^c   O'Byrne, Paul M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c Nycomed GmbH   (Germany)

Author keywords

Allergen challenge; Allergic asthma; Eosinophils; Inflammation; Neutrophils; PDE4 inhibitor; Sputum

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; LEUKOCYTE ELASTASE; METHACHOLINE; PLACEBO; ROFLUMILAST; ALLERGEN; AMINOPYRIDINE DERIVATIVE; BENZAMIDE DERIVATIVE; CYCLOPROPANE DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HEADACHE; HUMAN; MALE; NAUSEA; NEUTROPHIL; RESPIRATORY TRACT INFLAMMATION; TREATMENT DURATION; ADOLESCENT; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; IMMUNOLOGY; LOEFFLER PNEUMONIA; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PNEUMONIA; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; ALLERGENS; AMINOPYRIDINES; ASTHMA; BENZAMIDES; CROSS-OVER STUDIES; CYCLOPROPANES; DOUBLE-BLIND METHOD; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE 4 INHIBITORS; PNEUMONIA; PULMONARY EOSINOPHILIA; YOUNG ADULT;

EID: 81355154616     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-140     Document Type: Article

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