-
1
-
-
84866601389
-
Protein kinases of the Hippo pathway: Regulation and substrates
-
Avruch, J., Zhou, D., Fitamant, J., Bardeesy, N., Mou, F. and Barrufet, L.R. (2012) Protein kinases of the Hippo pathway: regulation and substrates. Semin. Cell Dev. Biol. 23, 770-784
-
(2012)
Semin. Cell Dev. Biol.
, vol.23
, pp. 770-784
-
-
Avruch, J.1
Zhou, D.2
Fitamant, J.3
Bardeesy, N.4
Mou, F.5
Barrufet, L.R.6
-
2
-
-
77957883342
-
The hippo signaling pathway in development and cancer
-
Pan, D. (2010) The hippo signaling pathway in development and cancer. Dev. Cell 19, 491-505
-
(2010)
Dev. Cell
, vol.19
, pp. 491-505
-
-
Pan, D.1
-
3
-
-
84865260845
-
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
-
Yu, F.X., Zhao, B., Panupinthu, N., Jewell, J.L., Lian, I., Wang, L.H., Zhao, J., Yuan, H., Tumaneng, K., Li, H. et al. (2012) Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell 150, 780-791
-
(2012)
Cell
, vol.150
, pp. 780-791
-
-
Yu, F.X.1
Zhao, B.2
Panupinthu, N.3
Jewell, J.L.4
Lian, I.5
Wang, L.H.6
Zhao, J.7
Yuan, H.8
Tumaneng, K.9
Li, H.10
-
4
-
-
70350502865
-
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
-
Zhou, D., Conrad, C., Xia, F., Park, J.S., Payer, B., Yin, Y., Lauwers, G.Y., Thasler, W., Lee, J.T., Avruch, J. and Bardeesy, N. (2009) Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16, 425-438
-
(2009)
Cancer Cell
, vol.16
, pp. 425-438
-
-
Zhou, D.1
Conrad, C.2
Xia, F.3
Park, J.S.4
Payer, B.5
Yin, Y.6
Lauwers, G.Y.7
Thasler, W.8
Lee, J.T.9
Avruch, J.10
Bardeesy, N.11
-
5
-
-
79958284636
-
Role of YAP/TAZ in mechanotransduction
-
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S. et al. (2011) Role of YAP/TAZ in mechanotransduction. Nature 474, 179-183
-
(2011)
Nature
, vol.474
, pp. 179-183
-
-
Dupont, S.1
Morsut, L.2
Aragona, M.3
Enzo, E.4
Giulitti, S.5
Cordenonsi, M.6
Zanconato, F.7
Le Digabel, J.8
Forcato, M.9
Bicciato, S.10
-
6
-
-
84883466306
-
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors
-
Aragona, M., Panciera, T., Manfrin, A., Giulitti, S., Michielin, F., Elvassore, N., Dupont, S. and Piccolo, S. (2013) A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 154, 1047-1059
-
(2013)
Cell
, vol.154
, pp. 1047-1059
-
-
Aragona, M.1
Panciera, T.2
Manfrin, A.3
Giulitti, S.4
Michielin, F.5
Elvassore, N.6
Dupont, S.7
Piccolo, S.8
-
7
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
-
O'Neill, E., Rushworth, L., Baccarini, M. and Kolch, W. (2004) Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306, 2267-2270
-
(2004)
Science
, vol.306
, pp. 2267-2270
-
-
O'neill, E.1
Rushworth, L.2
Baccarini, M.3
Kolch, W.4
-
8
-
-
34748812613
-
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
-
Matallanas, D., Romano, D., Yee, K., Meissl, K., Kucerova, L., Piazzolla, D., Baccarini, M., Vass, J.K., Kolch, W. and O'Neill, E. (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol. Cell 27, 962-975
-
(2007)
Mol. Cell
, vol.27
, pp. 962-975
-
-
Matallanas, D.1
Romano, D.2
Yee, K.3
Meissl, K.4
Kucerova, L.5
Piazzolla, D.6
Baccarini, M.7
Vass, J.K.8
Kolch, W.9
O'neill, E.10
-
9
-
-
76249097011
-
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
-
Romano, D., Matallanas, D., Weitsman, G., Preisinger, C., Ng, T. and Kolch, W. (2010) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 70, 1195-1203
-
(2010)
Cancer Res.
, vol.70
, pp. 1195-1203
-
-
Romano, D.1
Matallanas, D.2
Weitsman, G.3
Preisinger, C.4
Ng, T.5
Kolch, W.6
-
10
-
-
33845426464
-
The Drosophila RASSF homolog antagonizes the hippo pathway
-
Polesello, C., Huelsmann, S., Brown, N.H. and Tapon, N. (2006) The Drosophila RASSF homolog antagonizes the hippo pathway. Curr. Biol. 16, 2459-2465
-
(2006)
Curr. Biol.
, vol.16
, pp. 2459-2465
-
-
Polesello, C.1
Huelsmann, S.2
Brown, N.H.3
Tapon, N.4
-
11
-
-
76749165291
-
Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription
-
Rauch, J., O'Neill, E., Mack, B., Matthias, C., Munz, M., Kolch, W. and Gires, O. (2010) Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. Cancer Res. 70, 1679-1688
-
(2010)
Cancer Res.
, vol.70
, pp. 1679-1688
-
-
Rauch, J.1
O'neill, E.2
Mack, B.3
Matthias, C.4
Munz, M.5
Kolch, W.6
Gires, O.7
-
12
-
-
84875476208
-
The Hippo pathway and human cancer
-
Harvey, K.F., Zhang, X. and Thomas, D. M (2013) The Hippo pathway and human cancer. Nat. Rev. Cancer 13, 246-257
-
(2013)
Nat. Rev. Cancer
, vol.13
, pp. 246-257
-
-
Harvey, K.F.1
Zhang, X.2
Thomas, D.M.3
-
13
-
-
21344467538
-
Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo
-
O'Neill, E. and Kolch, W. (2005) Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo. Cell Cycle 4, 365-367
-
(2005)
Cell Cycle
, vol.4
, pp. 365-367
-
-
O'neill, E.1
Kolch, W.2
-
14
-
-
79960064432
-
Raf family kinases: Old dogs have learned new tricks
-
Matallanas, D., Birtwistle, M., Romano, D., Zebisch, A., Rauch, J., von Kriegsheim, A. and Kolch, W (2011) Raf family kinases: old dogs have learned new tricks. Genes Cancer 2, 232-260
-
(2011)
Genes Cancer
, vol.2
, pp. 232-260
-
-
Matallanas, D.1
Birtwistle, M.2
Romano, D.3
Zebisch, A.4
Rauch, J.5
Von Kriegsheim, A.6
Kolch, W.7
-
15
-
-
18144411303
-
Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
-
Agathanggelou, A., Cooper, W.N. and Latif, F. (2005) Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res. 65, 3497-3508
-
(2005)
Cancer Res.
, vol.65
, pp. 3497-3508
-
-
Agathanggelou, A.1
Cooper, W.N.2
Latif, F.3
-
16
-
-
76749165291
-
Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription
-
Rauch, J., O'Neill, E., Mack, B., Matthias, C., Munz, M., Kolch, W. and Gires, O. (2010) Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. Cancer Res. 70, 1679-1688
-
(2010)
Cancer Res.
, vol.70
, pp. 1679-1688
-
-
Rauch, J.1
O'neill, E.2
Mack, B.3
Matthias, C.4
Munz, M.5
Kolch, W.6
Gires, O.7
-
17
-
-
79251587189
-
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma
-
Lee, S.J., Lee, M.H., Kim, D.W., Lee, S., Huang, S., Ryu, M.J., Kim, Y.K., Kim, S.J., Hwang, J.H., Oh, S. et al. (2011) Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS ONE 6, e16180
-
(2011)
PLoS ONE
, vol.6
-
-
Lee, S.J.1
Lee, M.H.2
Kim, D.W.3
Lee, S.4
Huang, S.5
Ryu, M.J.6
Kim, Y.K.7
Kim, S.J.8
Hwang, J.H.9
Oh, S.10
-
18
-
-
84878263253
-
Phase I/II RAF kinase inhibitors in cancer therapy
-
Turajlic, S., Ali, Z., Yousaf, N. and Larkin, J. (2013) Phase I/II RAF kinase inhibitors in cancer therapy. Expert Opin. Invest. Drugs 22, 739-749
-
(2013)
Expert Opin. Invest. Drugs
, vol.22
, pp. 739-749
-
-
Turajlic, S.1
Ali, Z.2
Yousaf, N.3
Larkin, J.4
-
19
-
-
84855648341
-
Small molecule inhibitors of BRAF in clinical trials
-
Zambon, A., Niculescu-Duvaz, I., Niculescu-Duvaz, D., Marais, R. and Springer, C.J. (2012) Small molecule inhibitors of BRAF in clinical trials. Bioorg. Med. Chem. Lett. 22, 789-792
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 789-792
-
-
Zambon, A.1
Niculescu-Duvaz, I.2
Niculescu-Duvaz, D.3
Marais, R.4
Springer, C.J.5
-
20
-
-
80155151884
-
Vemurafenib
-
Flaherty, K.T., Yasothan, U. and Kirkpatrick, P. (2011) Vemurafenib. Nat. Rev. Drug Discov. 10, 811-812
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 811-812
-
-
Flaherty, K.T.1
Yasothan, U.2
Kirkpatrick, P.3
-
21
-
-
84875706825
-
Resistance to BRAF-targeted therapy in melanoma
-
Sullivan, R.J. and Flaherty, K.T. (2013) Resistance to BRAF-targeted therapy in melanoma. Eur. J. Cancer 49, 1297-1304
-
(2013)
Eur. J. Cancer
, vol.49
, pp. 1297-1304
-
-
Sullivan, R.J.1
Flaherty, K.T.2
-
22
-
-
82655173695
-
Resistance to BRAF inhibitors: Unraveling mechanisms and future treatment options
-
Villanueva, J., Vultur, A. and Herlyn, M. (2011) Resistance to BRAF inhibitors: unraveling mechanisms and future treatment options. Cancer Res. 71, 7137-7140
-
(2011)
Cancer Res.
, vol.71
, pp. 7137-7140
-
-
Villanueva, J.1
Vultur, A.2
Herlyn, M.3
-
23
-
-
43749120732
-
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications
-
Carnero, A., Blanco-Aparicio, C., Renner, O., Link, W. and Leal, J.F. (2008) The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr. Cancer Drug Targets 8, 187-198
-
(2008)
Curr. Cancer Drug Targets
, vol.8
, pp. 187-198
-
-
Carnero, A.1
Blanco-Aparicio, C.2
Renner, O.3
Link, W.4
Leal, J.F.5
-
24
-
-
84872170622
-
PTEN at a glance
-
Shi, Y., Paluch, B.E., Wang, X. and Jiang, X. (2012) PTEN at a glance. J. Cell Sci. 125, 4687-4692
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4687-4692
-
-
Shi, Y.1
Paluch, B.E.2
Wang, X.3
Jiang, X.4
-
25
-
-
84872825786
-
Suppression of survival signalling pathways by the phosphatase PHLPP
-
O'Neill, A.K., Niederst, M.J. and Newton, A.C. (2012) Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J. 280, 572-583
-
(2012)
FEBS J.
, vol.280
, pp. 572-583
-
-
O'neill, A.K.1
Niederst, M.J.2
Newton, A.C.3
-
26
-
-
84856741945
-
Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): A new player in cell signaling
-
Warfel, N.A. and Newton, A.C. (2011) Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J. Biol. Chem. 287, 3610-3616
-
(2011)
J. Biol. Chem.
, vol.287
, pp. 3610-3616
-
-
Warfel, N.A.1
Newton, A.C.2
-
27
-
-
77952562926
-
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis
-
Qiao, M., Wang, Y., Xu, X., Lu, J., Dong, Y., Tao, W., Stein, J., Stein, G.S., Iglehart, J.D., Shi, Q. and Pardee, A.B. (2010) Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol. Cell 38, 512-523
-
(2010)
Mol. Cell
, vol.38
, pp. 512-523
-
-
Qiao, M.1
Wang, Y.2
Xu, X.3
Lu, J.4
Dong, Y.5
Tao, W.6
Stein, J.7
Stein, G.S.8
Iglehart, J.D.9
Shi, Q.10
Pardee, A.B.11
-
28
-
-
84877936512
-
Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells
-
Cassinelli, G., Zuco, V., Gatti, L., Lanzi, C., Zaffaroni, N., Colombo, D. and Perego, P. (2013) Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells. Curr. Med. Chem. 20, 1923-1945
-
(2013)
Curr. Med. Chem.
, vol.20
, pp. 1923-1945
-
-
Cassinelli, G.1
Zuco, V.2
Gatti, L.3
Lanzi, C.4
Zaffaroni, N.5
Colombo, D.6
Perego, P.7
-
29
-
-
84878831559
-
Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway
-
Burris, 3rd, H.A. (2013) Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway. Cancer Chemother. Pharmacol. 71, 829-842
-
(2013)
Cancer Chemother. Pharmacol.
, vol.71
, pp. 829-842
-
-
Burris III, H.A.1
-
30
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
Downward, J. (2003) Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 11-22
-
-
Downward, J.1
-
31
-
-
1642553461
-
The dark side of Ras: Regulation of apoptosis
-
Cox, A.D. and Der, C.J. (2003) The dark side of Ras: regulation of apoptosis. Oncogene 22, 8999-9006
-
(2003)
Oncogene
, vol.22
, pp. 8999-9006
-
-
Cox, A.D.1
Der, C.J.2
-
32
-
-
84255187573
-
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras
-
Matallanas, D., Romano, D., Al-Mulla, F., O'Neill, E., Al-Ali, W., Crespo, P., Doyle, B., Nixon, C., Sansom, O., Drosten, M. et al. (2011) Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras. Mol. Cell 44, 893-906
-
(2011)
Mol. Cell
, vol.44
, pp. 893-906
-
-
Matallanas, D.1
Romano, D.2
Al-Mulla, F.3
O'neill, E.4
Al-Ali, W.5
Crespo, P.6
Doyle, B.7
Nixon, C.8
Sansom, O.9
Drosten, M.10
-
33
-
-
84866035571
-
EGF receptor signaling is essential for K-Ras oncogene-driven pancreatic ductal adenocarcinoma
-
Navas, C., Hernandez-Porras, I., Schuhmacher, A.J., Sibilia, M., Guerra, C. and Barbacid, M. (2012) EGF receptor signaling is essential for K-Ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell 22, 318-330
-
(2012)
Cancer Cell
, vol.22
, pp. 318-330
-
-
Navas, C.1
Hernandez-Porras, I.2
Schuhmacher, A.J.3
Sibilia, M.4
Guerra, C.5
Barbacid, M.6
-
34
-
-
84880170991
-
Loss of RASSF1A expression in colorectal cancer and its association with K-ras status
-
Cao, D., Chen, Y., Tang, Y., Peng, X.C., Dong, H., Li, L.H., Cheng, K., Ge, J. and Liu, J.Y. (2013) Loss of RASSF1A expression in colorectal cancer and its association with K-ras status. Biomed. Res. Int. 2013, 976765
-
(2013)
Biomed. Res. Int.
, vol.2013
, pp. 976765
-
-
Cao, D.1
Chen, Y.2
Tang, Y.3
Peng, X.C.4
Dong, H.5
Li, L.H.6
Cheng, K.7
Ge, J.8
Liu, J.Y.9
-
35
-
-
84876432917
-
The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics
-
Romano, D., Maccario, H., Doherty, C., Quinn, N.P., Kolch, W. and Matallanas, D. (2013) The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics. Mol. Cell. Biol. 33, 1859-1868
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1859-1868
-
-
Romano, D.1
Maccario, H.2
Doherty, C.3
Quinn, N.P.4
Kolch, W.5
Matallanas, D.6
-
36
-
-
84887532497
-
Requirement for interaction of PI3-kinase p110 with RAS in lung tumor maintenance
-
Castellano, E., Sheridan, C., Thin, M.Z., Nye, E., Spencer-Dene, B., Diefenbacher, M.E., Moore, C., Kumar, M.S., Murillo, M.M., Gronroos, E. et al. (2013) Requirement for interaction of PI3-kinase p110 with RAS in lung tumor maintenance. Cancer Cell 24, 617-630
-
(2013)
Cancer Cell
, vol.24
, pp. 617-630
-
-
Castellano, E.1
Sheridan, C.2
Thin, M.Z.3
Nye, E.4
Spencer-Dene, B.5
Diefenbacher, M.E.6
Moore, C.7
Kumar, M.S.8
Murillo, M.M.9
Gronroos, E.10
-
37
-
-
84871491627
-
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: How mutations can result in therapy resistance and how to overcome resistance
-
McCubrey, J.A., Steelman, L.S., Chappell, W.H., Abrams, S.L., Franklin, R.A., Montalto, G., Cervello, M., Libra, M., Candido, S., Malaponte, G. et al. (2012) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget 3, 1068-1111
-
(2012)
Oncotarget
, vol.3
, pp. 1068-1111
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Franklin, R.A.5
Montalto, G.6
Cervello, M.7
Libra, M.8
Candido, S.9
Malaponte, G.10
-
38
-
-
84868628069
-
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
-
McCubrey, J.A., Steelman, L.S., Chappell, W.H., Abrams, S.L., Montalto, G., Cervello, M., Nicoletti, F., Fagone, P., Malaponte, G., Mazzarino, M.C. et al. (2012) Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget 3, 954-987
-
(2012)
Oncotarget
, vol.3
, pp. 954-987
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Montalto, G.5
Cervello, M.6
Nicoletti, F.7
Fagone, P.8
Malaponte, G.9
Mazzarino, M.C.10
-
39
-
-
79960038169
-
Functional specificity of Ras isoforms: So similar but so different
-
Castellano, E. and Santos, E. (2011) Functional specificity of Ras isoforms: so similar but so different. Genes Cancer 2, 216-231
-
(2011)
Genes Cancer
, vol.2
, pp. 216-231
-
-
Castellano, E.1
Santos, E.2
-
40
-
-
84869447282
-
Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
-
Jeng, H.H., Taylor, L.J. and Bar-Sagi, D. (2012) Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis. Nat. Commun. 3, 1168
-
(2012)
Nat. Commun.
, vol.3
, pp. 1168
-
-
Jeng, H.H.1
Taylor, L.J.2
Bar-Sagi, D.3
-
41
-
-
84872853570
-
Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling
-
Young, A., Lou, D. and McCormick, F. (2012) Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 3, 112-123
-
(2012)
Cancer Discov.
, vol.3
, pp. 112-123
-
-
Young, A.1
Lou, D.2
McCormick, F.3
-
42
-
-
33645050117
-
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis
-
Oh, H.J., Lee, K.K., Song, S.J., Jin, M.S., Song, M.S., Lee, J.H., Im, C.R., Lee, J.O., Yonehara, S. and Lim, D.S. (2006) Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res. 66, 2562-2569
-
(2006)
Cancer Res.
, vol.66
, pp. 2562-2569
-
-
Oh, H.J.1
Lee, K.K.2
Song, S.J.3
Jin, M.S.4
Song, M.S.5
Lee, J.H.6
Im, C.R.7
Lee, J.O.8
Yonehara, S.9
Lim, D.S.10
-
43
-
-
3242794878
-
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
-
Praskova, M., Khoklatchev, A., Ortiz-Vega, S. and Avruch, J. (2004) Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem. J. 381, 453-462
-
(2004)
Biochem. J.
, vol.381
, pp. 453-462
-
-
Praskova, M.1
Khoklatchev, A.2
Ortiz-Vega, S.3
Avruch, J.4
-
44
-
-
0038485597
-
Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis
-
Deng, Y., Pang, A. and Wang, J.H. (2003) Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. J. Biol. Chem. 278, 11760-11767
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 11760-11767
-
-
Deng, Y.1
Pang, A.2
Wang, J.H.3
-
45
-
-
0037044808
-
Mapping of MST1 kinase sites of phosphorylation: Activation and autophosphorylation
-
Glantschnig, H., Rodan, G.A. and Reszka, A.A. (2002) Mapping of MST1 kinase sites of phosphorylation: activation and autophosphorylation. J. Biol. Chem. 277, 42987-42996
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42987-42996
-
-
Glantschnig, H.1
Rodan, G.A.2
Reszka, A.A.3
-
46
-
-
79953211893
-
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2
-
Guo, C., Zhang, X. and Pfeifer, G.P. (2011) The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2. J. Biol. Chem. 286, 6253-6261
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6253-6261
-
-
Guo, C.1
Zhang, X.2
Pfeifer, G.P.3
-
47
-
-
35548987430
-
The RASSF1A tumor suppressor
-
Donninger, H., Vos, M.D. and Clark, G.J. (2007) The RASSF1A tumor suppressor. J. Cell Sci. 120, 3163-3172
-
(2007)
J. Cell Sci.
, vol.120
, pp. 3163-3172
-
-
Donninger, H.1
Vos, M.D.2
Clark, G.J.3
-
48
-
-
76549127712
-
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
-
Song, H., Mak, K.K., Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R.M. et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 107, 1431-1436
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 1431-1436
-
-
Song, H.1
Mak, K.K.2
Topol, L.3
Yun, K.4
Hu, J.5
Garrett, L.6
Chen, Y.7
Park, O.8
Chang, J.9
Simpson, R.M.10
-
49
-
-
78650885839
-
Mst1/2 signalling to Yap: Gatekeeper for liver size and tumour development
-
Avruch, J., Zhou, D., Fitamant, J. and Bardeesy, N. (2010) Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br. J. Cancer 104, 24-32
-
(2010)
Br. J. Cancer
, vol.104
, pp. 24-32
-
-
Avruch, J.1
Zhou, D.2
Fitamant, J.3
Bardeesy, N.4
-
50
-
-
35148841871
-
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
-
Seidel, C., Schagdarsurengin, U., Blumke, K., Wurl, P., Pfeifer, G.P., Hauptmann, S., Taubert, H. and Dammann, R. (2007) Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol. Carcinog. 46, 865-871
-
(2007)
Mol. Carcinog.
, vol.46
, pp. 865-871
-
-
Seidel, C.1
Schagdarsurengin, U.2
Blumke, K.3
Wurl, P.4
Pfeifer, G.P.5
Hauptmann, S.6
Taubert, H.7
Dammann, R.8
-
51
-
-
14644420898
-
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
-
Takahashi, Y., Miyoshi, Y., Takahata, C., Irahara, N., Taguchi, T., Tamaki, Y. and Noguchi, S. (2005) Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin. Cancer Res. 11, 1380-1385
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1380-1385
-
-
Takahashi, Y.1
Miyoshi, Y.2
Takahata, C.3
Irahara, N.4
Taguchi, T.5
Tamaki, Y.6
Noguchi, S.7
-
52
-
-
84885418596
-
Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer
-
Lin, X., Cai, F., Li, X., Kong, X., Xu, C., Zuo, X. and Yang, Q. (2013) Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer. Tumour Biol. 34, 3239-3243
-
(2013)
Tumour Biol.
, vol.34
, pp. 3239-3243
-
-
Lin, X.1
Cai, F.2
Li, X.3
Kong, X.4
Xu, C.5
Zuo, X.6
Yang, Q.7
-
53
-
-
33847379007
-
Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer
-
Minoo, P., Zlobec, I., Baker, K., Tornillo, L., Terracciano, L., Jass, J.R. and Lugli, A. (2007) Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer. Mod. Pathol. 20, 331-338
-
(2007)
Mod. Pathol.
, vol.20
, pp. 331-338
-
-
Minoo, P.1
Zlobec, I.2
Baker, K.3
Tornillo, L.4
Terracciano, L.5
Jass, J.R.6
Lugli, A.7
-
54
-
-
79953204984
-
Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability
-
Ho, K.C., Zhou, Z., She, Y.M., Chun, A., Cyr, T.D. and Yang, X. (2013) Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability. Proc. Natl. Acad. Sci. U.S.A. 108, 4870-4875
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 4870-4875
-
-
Ho, K.C.1
Zhou, Z.2
She, Y.M.3
Chun, A.4
Cyr, T.D.5
Yang, X.6
-
55
-
-
79952266588
-
Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity
-
Salah, Z., Melino, G. and Aqeilan, R.I. (2011) Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity. Cancer Res. 71, 2010-2020
-
(2011)
Cancer Res.
, vol.71
, pp. 2010-2020
-
-
Salah, Z.1
Melino, G.2
Aqeilan, R.I.3
-
56
-
-
84875710846
-
WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells
-
Yeung, B., Ho, K.C. and Yang, X. (2013) WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells. PLoS ONE 8, e61027
-
(2013)
PLoS ONE
, vol.8
-
-
Yeung, B.1
Ho, K.C.2
Yang, X.3
-
57
-
-
84878596483
-
Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth
-
Lignitto, L., Arcella, A., Sepe, M., Rinaldi, L., Delle Donne, R., Gallo, A., Stefan, E., Bachmann, V.A., Oliva, M.A. et al. (2013) Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth. Nat. Commun. 4, 1822
-
(2013)
Nat. Commun.
, vol.4
, pp. 1822
-
-
Lignitto, L.1
Arcella, A.2
Sepe, M.3
Rinaldi, L.4
Delle Donne, R.5
Gallo, A.6
Stefan, E.7
Bachmann, V.A.8
Oliva, M.A.9
-
58
-
-
33745700212
-
Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
-
Teraishi, F., Guo, W., Zhang, L., Dong, F., Davis, J.J., Sasazuki, T., Shirasawa, S., Liu, J. and Fang, B. (2006) Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res. 66, 6072-6079
-
(2006)
Cancer Res.
, vol.66
, pp. 6072-6079
-
-
Teraishi, F.1
Guo, W.2
Zhang, L.3
Dong, F.4
Davis, J.J.5
Sasazuki, T.6
Shirasawa, S.7
Liu, J.8
Fang, B.9
|