The H50Q mutation enhances αα-synuclein aggregation, secretion, and toxicity

Journal of Biological Chemistry

Volumn 289, Issue 32, 2014, Pages 21856-21876

  Khalaf, Ossama ^a   Fauvet, Bruno ^a   Oueslati, Abid ^a   Dikiy, Igor ^b   Mahul Mellier, Anne Laure ^a   Ruggeri, Francesco Simone ^a   Mbefo, Martial K ^a   Vercruysse, Filip ^a   Dietler, Giovanni ^a   Lee, Seung Jae ^c   Eliezer, David ^b   Lashuel, Hilal A ^a  

^a EPFL   (Switzerland)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c Konkuk University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PHYSIOLOGY;

EXTRACELLULAR; MEMBRANE BINDING; PARKINSON DISEASE; SUBCELLULAR LOCALIZATIONS; SYNUCLEIN;

TOXICITY;

ALPHA SYNUCLEIN; METAL; MUTANT PROTEIN; PROTEIN AGGREGATE; RECOMBINANT PROTEIN; SNCA PROTEIN, HUMAN;

ANIMAL; CELL CULTURE; CELL DEATH; CELL LINE; CHEMISTRY; GENETICS; HUMAN; LIPID METABOLISM; METABOLISM; MISSENSE MUTATION; MOUSE; NERVE CELL; PARKINSON DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN QUATERNARY STRUCTURE; PROTEINOSIS;

ALPHA-SYNUCLEIN; ANIMALS; CELL DEATH; CELL LINE; CELLS, CULTURED; HUMANS; LIPID METABOLISM; METALS; MICE; MUTANT PROTEINS; MUTATION, MISSENSE; NEURONS; PARKINSON DISEASE; PHOSPHORYLATION; PROTEIN AGGREGATES; PROTEIN AGGREGATION, PATHOLOGICAL; PROTEIN STRUCTURE, QUATERNARY; RECOMBINANT PROTEINS;

EID: 84905852264     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.553297     Document Type: Article

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