Flexibilide obtained from cultured soft coral has anti-neuroinflammatory and analgesic effects through the upregulation of spinal transforming growth factor-β1 in neuropathic rats

Marine Drugs

Volumn 12, Issue 7, 2014, Pages 3792-3817

  Chen, Nan Fu ^a,b   Huang, Shi Ying ^a,c   Lu, Ching Hsiang ^b   Chen, Chun Lin ^b   Feng, Chien Wei ^a   Chen, Chun Hong ^a   Hung, Han Chun ^a   Lin, Yen You ^a   Sung, Ping Jyun ^d   Sung, Chun Sung ^e,f   Yang, San Nan ^g   Wang, Hui Min David ^h   Chang, Yu Chia ^a   Sheu, Jyh Horng ^a   Chen, Wu Fu ⁱ   Wen, Zhi Hong ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^c NATIONAL KAOHSIUNG UNIVERSITY OF APPLIED SCIENCES   (Taiwan)

^d NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^f NATIONAL YANG MING UNIVERSITY   (Taiwan)

^g I SHOU UNIVERSITY   (Taiwan)

^h KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

ⁱ CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Chronic constriction injury; Flexibilide; Microglial activation; Natural marine compound; Neuropathic pain; Spinal neuroinflammation; Transforming growth factor 1

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; FLEXIBILIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; NATURAL PRODUCT; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; LACTONE; PROTEIN SERINE THREONINE KINASE; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTI NEUROINFLAMMATORY EFFECT; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CELL ACTIVATION; CONTROLLED STUDY; CORAL; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INDUCTION; HYPERALGESIA; MALE; MICROGLIA; NEUROPATHIC PAIN; NONHUMAN; PROTEIN EXPRESSION; RAT; SINULARIA FLEXIBILIS; SPINAL CORD DORSAL HORN; THERMAL HYPERALGESIA; UPREGULATION; WEIGHT BEARING; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTHOZOA; DRUG EFFECTS; GLIA; METABOLISM; NEURALGIA; PHYSIOLOGY; WISTAR RAT;

ANALGESICS; ANIMALS; ANTHOZOA; ANTI-INFLAMMATORY AGENTS; HYPERALGESIA; LACTONES; MALE; NEURALGIA; NEUROGLIA; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 84905818206     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12073792     Document Type: Article

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