Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor β1 null mouse

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 2337-2342

  Vodovotz, Yoram ^a   Geiser, Andrew G ^a,b   Chesler, Louis ^a   Letterio, John J ^a   Campbell, Andrew ^a   Lucia, M Scott ^a,c   Sporn, Michael B ^a,d   Roberts, Anita B ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; MESSENGER RNA; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CELL CYCLE; CONTROLLED STUDY; ENZYME INDUCTION; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; WOUND HEALING;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BLOTTING, NORTHERN; ENZYME INDUCTION; GENE EXPRESSION; GENOTYPE; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KIDNEY; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; OMEGA-N-METHYLARGININE; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; REFERENCE VALUES; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029952226     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.2337     Document Type: Article

References (33)

1. Roberts, A.B., and M.B. Sporn. 1990. The transforming growth factor-betas. In Peptide Growth Factors and Their Receptors. M.B. Sporn and A.B. Roberts, editors. Springer-Verlag, Berlin. 419-472.
2. McCartney-Francis, N., and S.M. Wahl. 1994. Transforming growth factor β: a matter of life and death. J. Leukoc. Biol. 55: 401-409.
3. Ding, A., C.F. Nathan, J. Graycar, R. Derynck, D.J. Stuehr, and S. Srimal. 1990. Macrophage deactivating factor and transforming growth factors-β1, -β2, and -β3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-γ. J. Immunol. 145:940-944.
4. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051-3064.
5. Vodovotz, Y., and C. Bogdan. 1994. Control of nitric oxide synthase expression by transforming growth factor-β: implications for homeostasis. Prog. Growth Factor Res. 5:341-351.
6. Kulkarni, A.B., C. Huh, D. Becker, A. Geiser, M. Lyght, K.C. Flanders, A.B. Roberts, M.B. Sporn, J.M. Ward, and S. Karlsson. 1993. Transforming growth factor β1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA. 90:770-774.
7. Dang, H., A.G. Geiser, J.J. Letterio, T. Nakabayashi, L. Kong, G. Fernandes, and N. Talal. 1995. SLE-like autoantibodies and Sjörgen's syndrome-like lymphoproliferation in TGF-β "knock-out" mice. J. Immunol 155:3205-3212.
8. 1 null mouse phenotype. Proc. Natl. Acad. Sci. USA. 90:9944-9948.
9. Letterio, J.J., A.G. Geiser, A.B. Kulkarni, N.S. Roche, M.B. Sporn, and A.B. Roberts. 1994. Maternal rescue of transforming growth factor-β1 null mice. Science (Wash. DC). 264:1936-1938.
10. Vodovotz, Y. 1996. A modified assay for serum nitrite and nitrate. BioTechniques. 20:390-394.
11. Vodovotz, Y., C. Bogdan, J. Paik, Q. Xie, and C. Nathan. 1993. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-β. J. Exp. Med. 178: 605-613.
12. Misko, T.P., R.J. Schilling, D. Salvemini, W.M. Moore, and M.G. Currie. 1993. A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214:11-16.
13. Maniatis, T.E., E.F. Fritsch, and J. Sambrook. 1982. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY. 545 pp.
14. Church, G.M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA. 81:1991-1995.
15. Xie, Q.W., H.J. Cho, J. Calaycay, R.A. Mumford, K.M. Swiderek, T.D. Lee, A. Ding, T. Troso, and C. Nathan. 1992. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science (Wash. DC). 256: 225-228.
16. Derynck, R., J.A. Jarrett, E.Y. Chen, and D.V. Goeddel. 1986. The murine transforming growth factor-β precursor. J. Biol. Chem. 261:4377-4379.
17. Xie, Q., H. Cho, Y. Kashiwabara, M. Baum, J.R. Weidner, K. Elliston, R. Mumford, and C. Nathan. 1994. Carboxyl terminus of inducible nitric oxide synthase: contribution to NADPH binding and enzymatic activity. J. Biol. Chem. 269: 28500-28505.
18. Vodovotz, Y., D. Russell, Q. Xie, C. Bogdan, and C. Nathan. 1995. Vesicle association of nitric oxide synthase from primary mouse macrophages. J. Immunol. 154:2914-2925.
19. Shull, M.M., I. Ormsby, A.B. Kier, S. Pawlowski, R.J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature (Lond.). 359:693-699.
20. Harbrecht, B.G., T.R. Billiar, J.J. Stadler, A.J. Demetris, J. Ochoa, R.D. Curran, and R.L. Simmons. 1992. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury. J. Leukoc. Biol. 52:390-394.
21. Florquin, S., Z. Amraoui, C. Dubois, J. Decuyper, and M. Goldman. 1994. The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice. J. Exp. Med. 180:1153-1158.
22. Perrella, M.A., M. Yoshizumi, Z. Fen, J. Tsai, C. Hsieh, S. Kourembanas, and M. Lee. 1994. Transforming growth factor-β1, but not dexamethasone, down-regulates nitric-oxide synthase mRNA after its induction by interleukin-1β in rat smooth muscle cells. J. Biol. Chem. 269:14595-14600.
23. Finder, J., W.W. Stark, D.K. Nakayama, D. Geller, K. Wasserloos, B.R. Pitt, and P. Davies. 1995. TGF-β regulates production of NO in pulmonary-artery smooth-muscle cells by inhibiting expression of NOS. Am. J. Physiol. 12:L862-L867.
24. Szabó, C., C. Thiemermann, C. Wu, M. Perretti, and J.R. Vane. 1994. Attenuation of the induction of nitric oxide synthase by endogenous glucocorticoids accounts for endotoxin tolerance in vivo. Proc. Natl. Acad. Sci. USA. 91:271-275.
25. Vallance, P., A. Leone, A. Calver, J. Collier, and S. Moncada. 1992. Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J. Cardiovasc. Pharmacol. 20(Suppl.12):S60-S62.
26. Schini, V.B., S. Catovsky, T. Scott-Burden, and P.M. Vanhoutte. 1992. The inducible nitric oxide synthase is impaired by thrombin in vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 20(Suppl. 12):S142-S144.
27. Nakayama, I., Y. Kawahara, T. Tsuda, M. Okuda, and M. Yokoyama. 1994. Angiotensin II inhibits cytokine-stimulated inducible nitric oxide synthase expression in vascular smooth muscle cells. J. Biol. Chem. 269:11628-11633.
28. Hwang, S., C.A. Lopez, D.E. Heck, C.R. Gardner, D.L. Laskin, J.D. Laskin, and D.T. Denhardt. 1994. Osteopontin inhibits induction of nitric oxide synthase gene expression by inflammatory mediators in mouse kidney epithelial cells. J. Biol. Chem. 269:711-715.
29. Cross, A.H., T.P. Misko, R.F. Lin, W.F. Hickey, J.L. Trotter, and R.G. Tilton. 1994. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93: 2684-2690.
30. G-monomethyl-L-arginine. J. Exp. Med. 179:651-660.
31. Lowrance, J.H., F.X. O'Sullivan, T.E. Caver, W. Waegell, and H.D. Gresham. 1994. Spontaneous elaboration of transforming growth factor β suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J. Exp. Med. 180:1693-1703.
32. Mills, C.D. 1991. Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway. J. Immunol. 146:2719-2723.
33. Christ, M., N.L. McCartney-Francis, A.B. Kulkarni, J.M. Ward, D.E. Mizel, C.L. Mackall, R.E. Gress, K.L. Hines, H. Tian, S. Karlsson, and S.M. Wahl. 1994. Immune dysregulation in TGF-β1-deficient mice. J. Immunol. 153:1936-1946.