Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni

European Journal of Pharmacology

Volumn 578, Issue 2-3, 2008, Pages 323-331

  Jean, Yen Hsuan ^a   Chen, Wu Fu ^b   Duh, Chang Yi ^c   Huang, Shi Ying ^c   Hsu, Chi Hsin ^c   Lin, Chan Shing ^c   Sung, Chun Sung ^d   Chen, I Ming ^c   Wen, Zhi Hong ^c  

^a PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Analgesia; Carrageenan; COX 2; Inflammation; iNOS; Intrathecal; Lemnalol

Indexed keywords

8 ISOPROPYL 5 METHYL 4 METHYLENE DECAHYDRO 1,5 CYCLO NAPHTHALEN 3 OL; ANALGESIC AGENT; CARRAGEENAN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CORAL; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; HYPERALGESIA; LEMNALIA CERVICORNI; MALE; NOCICEPTION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TAIWAN; UPREGULATION; WESTERN BLOTTING;

ANALGESICS; ANIMALS; ANTHOZOA; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INJECTIONS, SPINAL; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; NEUTROPHIL INFILTRATION; NITRIC OXIDE SYNTHASE TYPE II; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, WISTAR; SESQUITERPENES; TIME FACTORS;

EID: 37349035250     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.08.048     Document Type: Article

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