Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: Association with changes of mitogen-activated protein kinase in chondrocytes

Osteoarthritis and Cartilage

Volumn 18, Issue 9, 2010, Pages 1192-1202

  Wen, Z H ^a   Tang, C C ^b   Chang, Y C ^a   Huang, S Y ^a   Hsieh, S P ^c   Lee, C H ^d   Huang, G S ^e   Ng, H F ^c   Neoh, C A ^c   Hsieh, C S ^c   Chen, W F ^f   Jean, Y H ^c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL PINGTUNG UNIVERSITY   (Taiwan)

^c PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Anterior cruciate ligament; Glucosamine; MAPK; Nociception; Osteoarthritis

Indexed keywords

GLUCOSAMINE SULFATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; PLACEBO; STRESS ACTIVATED PROTEIN KINASE;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT INJURY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NOCICEPTION; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNOVIUM; WEIGHT BEARING;

ADMINISTRATION, ORAL; ANIMALS; BEHAVIOR, ANIMAL; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE MODELS, ANIMAL; FUNCTIONAL LATERALITY; GLUCOSAMINE; IMMUNOHISTOCHEMISTRY; KNEE JOINT; MITOGEN-ACTIVATED PROTEIN KINASES; NOCICEPTORS; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; RATS; RATS, WISTAR; SYNOVIAL MEMBRANE; WEIGHT-BEARING;

EID: 77956010285     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2010.05.012     Document Type: Article

References (50)

1. Pelletier J.P., Martel-Pelletier J., Abramson S.B. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001, 44(6):1237-1247.
2. Bajaj P., Baja P., Graven-Nielsen T., Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain 2001, 93:107-114.
3. Bradley L.A., Kersh B.C., DeBerry J.J., Deutsch G., Alarcon G.A., McLain D.A. Lessons from fibromyalgia: abnormal pain sensitivity in knee osteoarthritis. Novartis Found Symp 2004, 260:258-270. (Discussion 270-279).
4. Schaible H.G. Spinal mechanisms contributing to joint pain. Osteoarthritic joint pain. Novartis Found Symp 2004, 260:4-27.
5. Reginster J.Y., Deroisy R., Rovati L.C., Lee R.L., Lejeune E., Bruyere O., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet 2001, 357:251-256.
6. Setnikar I., Pacini M.A., Revel L. Anti-arthritic effects of glucosamine sulfate studied in animal models. Arzneimittelforschung 1991, 41:542-550.
7. Pavelka K., Gatterova J., Olejarova M., Machacek S., Giacovelli G., Rovati L.C. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 2002, 162:2113-2123.
8. Rozendaal R.M., Uitterlinden E.J., van Osch G.J.V.M., Garling E.H., Willemsen S.P., Ginai A.Z., et al. Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial. Osteoarthritis Cartilage 2009, 17:427-432.
9. Damjanov N., Kauffman R.S., Spencer-Green G.T. Efficacy, pharmacodynamics, and safety of CX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis. Arthritis Rheum 2009, 60:1232-1241.
10. Clancy R., Rediske J., Koehne C., Stoyanovsky D., Amin A., Attur M., et al. Activation of stress-activated protein kinase in osteoarthritic cartilage: evidence for nitric oxide dependence. Osteoarthritis Cartilage 2001, 9:294-299.
11. Fan Z., Soder S., Oehler S., Fundel K., Aigner T. Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage. Am J Pathol 2007, 171:938-946.
12. Giovannini M.G. The role of the extracellular signal-regulated kinase pathway in memory encoding. Rev Neurosci 2006, 17(6):619-634.
13. Rajapakse N., Kim M.M., Mendis E., Kim S.K. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-κB signaling. Immunology 2008, 123:348-357.
14. Boileau C., Martel-Pelletier J., Brunet J., Schrier D., Flory C., Boily M., et al. PD-0200347, an alpha 2 delta ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKC alpha dependent effect. Ann Rheum Dis 2006, 65:573-580.
15. Brown K.K., Heitmeyer S.A., Hookfin E.B., Hsieh L., Buchalova M., Taiwo Y.O., et al. P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis. J Inflamm 2008, 5:22-29.
16. Sondergaard B.C., Schultz N., Madsen S.H., Bay-Jensen A.C., Kassem M., Karsdal M.A. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation - divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage 2009, 10.1016/j.joca.2009.11.005.
17. Jean Y.H., Wen Z.H., Chang Y.C., Hsieh S.P., Tang C.C., Wang Y.H., et al. Intra-articular injection of cyclooxygenase-2 inhibitor parecoxib attenuates osteoarthritis progression in anterior cruciate ligament-transection knee in rats: role of excitatory amino acids. Osteoarthritis Cartilage 2007, 15:638-645.
18. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neuro Meth 1994, 53:55-63.
19. Fernihough J., Gentry C., Malcangio M., Fox A., Rediske J., Pellas T., et al. Pain related behaviour in two models of osteoarthritic in the rat knee. Pain 2004, 112:83-93.
20. Bove S.E., Laemont K.D., Brooker R.M., Osborn M.N., Sanchez B.M., Guzman R.E., et al. Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia. Osteoarthritis Cartilage 2006, 14(10):1041-1048.
21. Pomonis J.D., Boulet J.M., Gottshall S.L., Phillips S., Sellers R., Bunton T., et al. Development and pharmacological characterization of a rat model of osteoarthritis pain. Pain 2005, 114(3):339-346.
22. Pelletier J.P., Lascau-Coman V., Jovanovic D., Fernandes J.C., Manning P., Connor J.R., et al. Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol 1999, 26:2002-2014.
23. Mankin H.J., Dorfman H., Lippiello L., Zarins A. Biochemical and metabolic abnormalities in articular cartilage from osteoarthritic human hips. II Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg 1971, 53A:523-537.
24. Yoshimi T., Kikuchi T., Obara T., Yamaguchi T., Sakakibara Y., Itoh H., et al. Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthritis induced by the resection of rabbit cruciate ligament. Clin Orthop Relat Res 1994, 298:296-304.
25. Jean Y.H., Wen Z.H., Chang Y.C., Hsieh S.P., Tang C.C., Lin J.D., et al. Increase in excitatory amino acid concentration and transporters expression in osteoarthritic knees of anterior cruciate ligament transected rabbits. Osteoarthritis Cartilage 2008, 16:1442-1449.
26. Lee C.H., Wen Z.H., Chang Y.C., Huang S.Y., Tang C.C., Chen W.F., et al. Intra-articular magnesium sulfate (MgSO4) reduces experimental osteoarthritis and nociception: association with attenuation of N-methyl-d-aspartate (NMDA) receptor subunit 1 phosphorylation and apoptosis in rat chondrocytes. Osteoarthritis Cartilage 2009, 17:1485-1493.
27. Wu H., Du J., Zheng Q. Expression of MMP-1 in cartilage and synovium of experimentally induced rabbit ACLT traumatic osteoarthritis: immunohistochemical study. Rheumatol Int 2008, 9:31-36.
28. Brandt K.D., Myers S.L., Burr D., Albrecht M. Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament. Arthritis Rheum 1991, 34:1560-1570.
29. Wang S., Cherian A., Laverty S., Dumitriu M., Plaas A., Grynpas M.D. The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum 2007, 56(5):1537-1548.
30. Tiraloche G., Girard C., Chouinard L., Sampalis J., Moquin L., Ionescu M., et al. Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum 2005, 52(4):1118-1128.
31. Levine J.D., Reichling D.B. Peripheral mechanisms of inflammatory pain. Textbook of pain 1999, 9-84. Churchill Livingstone, Hong Kong. 4th edn. P.D. Wall, R. Melzack (Eds.).
32. Castro R.R., Cunha F.Q., Silva F.S., Rocha F.A.C. A quantitative approach to measure joint pain in experimental osteoarthritis-evidence of a role of nitric oxide. Osteoarthritis Cartilage 2006, 14:769-776.
33. Petersen S.G., Saxne T., Heinegard D., Hansen M., Holm L., Koskinen S., et al. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage 2010, 18:34-40.
34. Varghese S., Theprungsirikul P., Sahani S., Hwang N., Yarema K.J., Elisseeff J.H. Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. Osteoarthritis Cartilage 2007, 15:59-68.
35. Nakamura H., Shibakawa A., Tanaka M., Kato T., Nishioka K. Effects of glucosamine hydrochloride on the production of prostaglandin R22, nitric oxide and metalloproteinase by chondrocytes and synoviocytes in osteoarthritis. Clin Exp Rheumatol 2004, 22:293-299.
36. Panicker S., Borgia J., Fhied C., Mikecz K., Oegema T.R. Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair. Osteoarthritis Cartilage 2009, 17:1014-1021.
37. Sandy J.D., Thompson V., Verscharen C., Gamett D. Chondrocyte-mediated catabolism on aggrecan: evidence for glycosyl-phosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid. Arch Biochem Biophys 1999, 367:258-264.
38. Gouze J.N., Bianchi A., Necuwe P., Dauca M., Netter P., Magdalou J., et al. Glucosamine modulates IL-1-induced activation of rat chondrocytes at a receptor level, and by inhibiting the NF-kB pathway. FEBS Lett 2002, 510:166-170.
39. Scotto d'Abusco A., Calamia V., Cicione C., Grigolo B., Politi L., Scandurra R. Glucosamine affects intracellular signaling through inhibition of mitogen-activated protein kinase phosphorylation in human chondrocytes. Arthritis Res Ther 2007, 9(5):104-111.
40. Loeuille D., Rat A.C., Goebel J.C., Champigneulle J., Blum A., Netter P., et al. Magnetic resonance imaging in osteoarthritis: which method best reflects synovial membrane inflammation? Correlations with clinical, macroscopic and microscopic features. Osteoarthritis Cartilage 2009, 17(9):1186-1192.
41. Hill C.L., Gale D.G., Chaisson C.E., Skinner K., Kazis L., Gale M.E., et al. Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol 2001, 28:1330-1337.
42. Hua J., Suguro S., Hirano S., Sakamoto K., Nagaoka I. Preventive actions of a high dose of glucosamine on adjuvant arthritis in rats. Inflamm Res 2005, 54:127-132.
43. Mendes A.F., Caramona M.M., Carvalho A.P., Lopes M.C. Role of mitogen-activated proein kinase and tyrosine kinases on IL-1-induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes. Nitric Oxide 2002, 6:35-44.
44. Nishikawa M., Myoui A., Tomita T., Takahi K., Nampei A., Yoshikawa H. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis Rheum 2003, 48:2670-2681.
45. Ji R.R., Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 2001, 8:1-10.
46. Furestein G.S., Manning A.M. Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum 1999, 42:609-621.
47. Lumpkin E.A., Caterina M.J. Mechanisms of sensory transduction in the skin. Nature 2007, 445:858-865.
48. Hucho T., Levine J.D. Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 2007, 55:365-376.
49. Nieminen R., Leinonen S., Lahti A., Vuolteeenaho K., Jalonen U., Kankaanranta H., et al. Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes. Mediators Inflamm 2005, 5:249-255.
50. Djouad F., Rackwitz L., Song Y., Janjanin S., Tuan R. ERK1/2 activation induced by inflammatory cytokines compromises effective host tissue integration of engineered cartilage. Tissue Eng Part A 2009, 15(10):2825-2835.