Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1843, Issue 7, 2014, Pages 1295-1307

  Cilenti, Lucia ^a   Ambivero, Camilla T ^a   Ward, Nathan ^a   Alnemri, Emad S ^b   Germain, Doris ^c   Zervos, Antonis S ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Mitophagy; Mnd2 mouse; Mulan E3 ubiquitin ligase; Omi HtrA2; Oxidative stress

Indexed keywords

HYDROGEN PEROXIDE; MITOCHONDRIAL PROTEIN; MITOFUSIN 2; MULAN PROTEIN; SERINE PROTEINASE OMI; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE; MFN2 PROTEIN, MOUSE; SERINE PROTEINASE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELLULAR STRESS SIGNAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; MITOPHAGY; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; TISSUE LEVEL; ANIMAL; APOPTOSIS; CELL LINE; CELL NUCLEUS; CYTOPLASM; DEFICIENCY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MOTOR NEURON DISEASE; OXIDATIVE STRESS; PATHOLOGY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

AGING, PREMATURE; ANIMALS; APOPTOSIS; CELL LINE; CELL NUCLEUS; CYTOPLASM; FIBROBLASTS; GENE EXPRESSION REGULATION; GTP PHOSPHOHYDROLASES; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; MOTOR NEURON DISEASE; OXIDATIVE STRESS; PROTEIN TRANSPORT; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 84905696703     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.03.027     Document Type: Article

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