The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity

Biochemical and Biophysical Research Communications

Volumn 387, Issue 3, 2009, Pages 537-542

  Park, Hye Min ^a   Kim, Goo Young ^b   Nam, Min Kyung ^b   Seong, Geun Hye ^a   Han, Chul ^a   Chung, Kwang Chul ^c   Kang, Seongman ^a   Rhim, Hyangshuk ^b  

^a Korea University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Yonsei University   (South Korea)

Author keywords

E3 ubiquitin ligase; HtrA2; Parkin; Serine protease; Ubiquitination

Indexed keywords

PARKIN; PROTEASOME; PROTEIN; SERINE PROTEINASE OMI; SYNPHILIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRESS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME LOCALIZATION; FIBROBLAST; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ANIMALS; CARRIER PROTEINS; CELL LINE; CYTOSOL; FIBROBLASTS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; NERVE TISSUE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; SERINE ENDOPEPTIDASES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 68249124331     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.079     Document Type: Article

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