Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells

PLoS ONE

Volumn 9, Issue 8, 2014, Pages

  Pedersen, Morten Gram ^a,c   Salunkhe, Vishal Ashok ^a   Svedin, Emma ^b   Edlund, Anna ^a   Eliasson, Lena ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; EGTAZIC ACID; INSULIN; CALCIUM;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL STIMULATION; CONTROLLED STUDY; DEPOLARIZATION; EXOCYTOSIS; IMMEDIATELY RELEASABLE POOL; INSULIN RELEASE; INSULINOMA CELL LINE; MEMBRANE CAPACITANCE; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP TECHNIQUE; RAT; SECRETORY GRANULE; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; ELECTRIC CAPACITANCE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CALCIUM; CELL LINE, TUMOR; CELL MEMBRANE; ELECTRIC CAPACITANCE; EXOCYTOSIS; INSULIN; INSULIN-SECRETING CELLS; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; RATS;

EID: 84905671646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103874     Document Type: Article

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