Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes

Molecular and Cellular Endocrinology

Volumn 364, Issue 1-2, 2012, Pages 36-45

  Andersson, Sofia A ^a   Olsson, Anders H ^a   Esguerra, Jonathan L S ^a   Heimann, Emilia ^b   Ladenvall, Claes ^a   Edlund, Anna ^a   Salehi, Albert ^a   Taneera, Jalal ^a   Degerman, Eva ^b   Groop, Leif ^a   Ling, Charlotte ^a   Eliasson, Lena ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Beta cell; BIS; DGI; Exocytosis; GSIS; GWAS; Islet; SNP; SYT; T2D; Type 2 diabetes

Indexed keywords

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EXOCYTOSIS; FEMALE; GENE; GENE EXPRESSION; GENE SILENCING; GLUCOSE HOMEOSTASIS; HUMAN; HUMAN CELL; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PHENOTYPE; PRIORITY JOURNAL; RAT; SINGLE NUCLEOTIDE POLYMORPHISM; SNAP25 GENE; STX1A GENE; STXBP1 GENE; SYT11 GENE; SYT13 GENE; SYT4 GENE; SYT7 GENE;

AGED; ANIMALS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EXOCYTOSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE SILENCING; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; ISLETS OF LANGERHANS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; TISSUE CULTURE TECHNIQUES;

EID: 84867518459     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.08.009     Document Type: Article

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