Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

Biochemical Journal

Volumn 450, Issue 3, 2013, Pages 595-605

  Spégel, Peter ^a   Sharoyko, Vladimir V ^a   Goehring, Isabel ^a   Danielsson, Anders P H ^a   Malmgren, Siri ^a   Nagorny, Cecilia L F ^a   Andersson, Lotta E ^a   Koeck, Thomas ^a   Sharp, Geoffrey W G ^b   Straub, Susanne G ^b   Wollheim, Claes B ^a,c   Mulder, Hindrik ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Department of Obstetrics Gynecology   (United States)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Glutathione; Islets; Mass spectrometry; NADPH; Ribose 5 phosphate; Type 2 diabetes

Indexed keywords

GLUTATHIONE; INSULIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE 5 PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; INSULIN RELEASE; MALE; METABOLIC REGULATION; METABOLISM; METABOLOMICS; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE METABOLISM; PANCREAS ISLET BETA CELL; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; RAT; STIMULUS SECRETION COUPLING;

ANIMALS; CELL RESPIRATION; CELLS, CULTURED; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; METABOLOME; METABOLOMICS; MITOCHONDRIA; PENTOSE PHOSPHATE PATHWAY; RATS; RATS, WISTAR; SECRETORY PATHWAY;

EID: 84874587805     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121349     Document Type: Article

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