Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK

Islets

Volumn 2, Issue 4, 2010, Pages 236-239

  Persaud, Shanta J ^a   Arden, Catherine ^b   Bergsten, Peter ^c   Bone, Adrian J ^d   Brown, James ^e   Dunmore, Simon ^f   Harrison, Moria ^d   Hauge Evans, Astrid ^a   Kelly, Catriona ^g   King, Aileen ^a   Maffucci, Tania ^h   Marriott, Claire E ^d   McClenaghan, Neville ^g   Morgan, Noel G ⁱ   Reers, Christina ^a   Russell, Mark A ⁱ   Turner, Mark D ^h   Willoughby, Emma ^j   Younis, Mustafa Y G ^a,k   Zhi, Z L ^a   Jones, Peter M ^a   more..

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF BRIGHTON   (United Kingdom)

^e ASTON UNIVERSITY   (United Kingdom)

^f UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^g UNIVERSITY OF ULSTER   (United Kingdom)

^h QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

ⁱ PENINSULA MEDICAL SCHOOL   (United Kingdom)

^j National Centre for the Replacement   (United Kingdom)

^k UNIVERSITY OF WARWICK   (United Kingdom)

more..

Author keywords

cell function; Insulin secretion; Islet substitutes; MIN6 cells; Pseudoislets; Symposium

Indexed keywords

CATENIN; CELL ADHESION MOLECULE; COLLAGENASE; GLUCOSE; GLYCOLYTIC ENZYME; INSULIN; UVOMORULIN;

CELL COMMUNICATION; CELL ISOLATION; CELL LINE; CELL PROLIFERATION; COST; DISEASE MODEL; FUNCTIONAL PROTEOMICS; GAP JUNCTION; GLUCOSE BLOOD LEVEL; IMMUNOCYTOCHEMISTRY; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN SYNTHESIS; ISOLATION PROCEDURE; MOUSE; NONHUMAN; ORGAN DONOR; PANCREAS INSUFFICIENCY; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PARACRINE SIGNALING; PROTEIN DEGRADATION; REVIEW; SECRETORY CELL; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMAL USE ALTERNATIVES; ANIMALS; BIOMEDICAL RESEARCH; CELL CULTURE TECHNIQUES; CELL LINE; CONGRESSES AS TOPIC; ENDOCRINOLOGY; GREAT BRITAIN; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; LONDON; MICE;

EID: 77957096453     PISSN: 19382014     EISSN: 19382022     Source Type: Journal    
DOI: 10.4161/isl.2.4.12557     Document Type: Review

References (19)

1. Lacy PE, Young DA, Fink CJ. Studies on insulin secretion in vitro from isolated islets of the rat pancreas. Endocrinology 1966; 83:1155-61.
2. Howell SL, Taylor KW. Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans. Biochim Biophys Acta 1966; 130:519-21.
3. Shibata A, Ludvigsen CW, Naber SP, McDaniel ML, Lacy PE. Standardization of a digestion-filtration method for isolation of pancreatic islets. Diabetes 1976; 25:667-72.
4. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343:230-8. (Pubitemid 30490390)
5. Fiorina P, Shapiro AM, Ricordi C, Secchi A. The clinical impact of islet transplantation. Am J Transplant 2008; 8:1990-7.
6. Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A. The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 2006; 103:2334-9.
7. JDRF Human Islet Resource Centers (accessed 28/04/2010) http://www.jdrf.org/files/General-Files/For-Scientists/MS2010/ Applying-for-Human-Islets-020210.pdf.
8. Persaud SJ. Pancreatic β-cell lines: their roles in β-cell research and diabetes therapy. Advances in Molecular and Cell Biology 2009; 29:21-46.
9. Carvell M, Persaud SJ, Jones PM. An islet is greater than the sum of its parts: the importance of intercellular communication in insulin secretion. Cellscience Reviews 2006; 3:100-28.
10. Gingerich RL, Scharp DW, Greider MH, Dye ES, Mousel KA. A new in vitro model for studies of pancreatic polypeptide secretion and biochemistry. Regul Pept 1982; 5:13-25. (Pubitemid 13192916)
11. Hopcroft DW, Mason DR, Scott RS. Insulin secretion from perifused rat pancreatic pseudoislets. In Vitro Cell Dev Biol 1985; 21:421-7.
12. Fält K, Odselius R, Schröder D, Wegner U, Zühlke H. Ultrastructural basis for pseudoislet formation in cultivated isolated islet cells from neonatal rats. Biomed Biochim Acta 1985; 44:45-8.
13. 2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 1999; 48:1402-8.
14. Luther MJ, Hauge-Evans A, Roberts G, Christie M, Souza KLA, Jörns A, et al. Homotypic β-cell-β-cell interactions influences insulin secretory responses to nutrients and non-nutrients. Biochem Biophys Res Comm 2006; 343:99-104.
15. Rogers GJ, Hodgkin MN, Squires PE. E-cadherin and cell adhesion: a role in architecture and function in the pancreatic islet. Cell Physiol Biochem 2007; 20:987-94.
16. Kopska T, Fürstova V, Kovar J. The effect of pseudoislet formation on insulin production in beta cells in vitro Diabetologia 2007; 50:0524.
17. Pethig R, Menachery A, Heart A, Sanger RH, Smith PJ. Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into three-dimensional pseudo-islet constructs. IET Nanotechnology 2008; 2:31.
18. Maillard E, Sencier MC, Langlois A, Bietiger W, Krafft MP, Pinget M, et al. Extracellular matrix proteins involved in pseudoislets formation. Islets 2009; 1:232-41.
19. Fornoni A, Jeon J, Varona Santos J, Cobianchi L, Jauregui A, Inverardi L, et al. Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes 2010; 59:190-9.