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Volumn 35, Issue 8, 2014, Pages 384-396

Epigenetic mechanisms of importance for drug treatment

Author keywords

5 hydroxymethylcytosine; DNA methylation; epidrugs; epigenetic editing; histone modifications; pharmacoepigenetics

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 HYDROXYMETHYLCYTOSINE; AZACITIDINE; BUTYRIC ACID; CARBOPLATIN; DIETHYLSTILBESTROL; DNA; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; DOCETAXEL; DOXORUBICIN; ENTINOSTAT; EXEMESTANE; GLUTATHIONE TRANSFERASE P1; HISTONE; HYDRALAZINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MOCETINOSTAT; OPIATE; PANOBINOSTAT; PROTEIN TYROSINE KINASE INHIBITOR; RNA; ROMIDEPSIN; SECRETED FRIZZLED RELATED PROTEIN 5; TAMOXIFEN; TEMOZOLOMIDE; UNINDEXED DRUG; VALPROATE MAGNESIUM; VALPROIC ACID; VORINOSTAT;

EID: 84905513547     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2014.05.004     Document Type: Review
Times cited : (120)

References (93)
  • 1
    • 79651470986 scopus 로고    scopus 로고
    • Pharmacogenomic biomarkers: New tools in current and future drug therapy
    • S.C. Sim, and M. Ingelman-Sundberg Pharmacogenomic biomarkers: new tools in current and future drug therapy Trends Pharmacol. Sci. 32 2011 72 81
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 72-81
    • Sim, S.C.1    Ingelman-Sundberg, M.2
  • 2
    • 84880727398 scopus 로고    scopus 로고
    • The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming challenges of real-world implementation
    • A.R. Shuldiner et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation Clin. Pharmacol. Ther. 94 2013 207 210
    • (2013) Clin. Pharmacol. Ther. , vol.94 , pp. 207-210
    • Shuldiner, A.R.1
  • 3
    • 84897557155 scopus 로고    scopus 로고
    • Digging up the human genome: Current progress in deciphering adverse drug reactions
    • S.C. Su et al. Digging up the human genome: current progress in deciphering adverse drug reactions Biomed. Res. Int. 2014 2014 824343
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 824343
    • Su, S.C.1
  • 4
    • 84867400649 scopus 로고    scopus 로고
    • DNA methylation based biomarkers: Practical considerations and applications
    • A. How Kit et al. DNA methylation based biomarkers: practical considerations and applications Biochimie 94 2012 2314 2337
    • (2012) Biochimie , vol.94 , pp. 2314-2337
    • How Kit, A.1
  • 5
    • 84860371953 scopus 로고    scopus 로고
    • Epigenetic protein families: A new frontier for drug discovery
    • C.H. Arrowsmith et al. Epigenetic protein families: a new frontier for drug discovery Nat Rev. Drug Discov. 11 2012 384 400
    • (2012) Nat Rev. Drug Discov. , vol.11 , pp. 384-400
    • Arrowsmith, C.H.1
  • 6
    • 84867185582 scopus 로고    scopus 로고
    • Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver
    • W.D. Chen et al. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver Hepatology 56 2012 1499 1509
    • (2012) Hepatology , vol.56 , pp. 1499-1509
    • Chen, W.D.1
  • 7
    • 84878843769 scopus 로고    scopus 로고
    • Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver
    • J.P. Thomson et al. Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver Nucleic Acids Res. 41 2013 5639 5654
    • (2013) Nucleic Acids Res. , vol.41 , pp. 5639-5654
    • Thomson, J.P.1
  • 8
    • 84861839326 scopus 로고    scopus 로고
    • CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression
    • R. Chatterjee, and C. Vinson CpG methylation recruits sequence specific transcription factors essential for tissue specific gene expression Biochim. Biophys. Acta 1819 2012 763 770
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 763-770
    • Chatterjee, R.1    Vinson, C.2
  • 9
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • R.A. Irizarry et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores Nat. Genet. 41 2009 178 186
    • (2009) Nat. Genet. , vol.41 , pp. 178-186
    • Irizarry, R.A.1
  • 10
    • 84886834154 scopus 로고    scopus 로고
    • Identification of active regulatory regions from DNA methylation data
    • L. Burger et al. Identification of active regulatory regions from DNA methylation data Nucleic Acids Res. 41 2013 e155
    • (2013) Nucleic Acids Res. , vol.41 , pp. 155
    • Burger, L.1
  • 11
    • 84872107212 scopus 로고    scopus 로고
    • Stereoselective access to Z and e macrocycles by ruthenium-catalyzed Z-selective ring-closing metathesis and ethenolysis
    • V.M. Marx et al. Stereoselective access to Z and E macrocycles by ruthenium-catalyzed Z-selective ring-closing metathesis and ethenolysis J. Am. Chem. Soc. 135 2013 94 97
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 94-97
    • Marx, V.M.1
  • 12
    • 84355163093 scopus 로고    scopus 로고
    • DNA-binding factors shape the mouse methylome at distal regulatory regions
    • M.B. Stadler et al. DNA-binding factors shape the mouse methylome at distal regulatory regions Nature 480 2011 490 495
    • (2011) Nature , vol.480 , pp. 490-495
    • Stadler, M.B.1
  • 13
    • 70349329405 scopus 로고    scopus 로고
    • Many paths to one goal? the proteins that recognize methylated DNA in eukaryotes
    • N. Sasai, and P.A. Defossez Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes Int. J. Dev. Biol. 53 2009 323 334
    • (2009) Int. J. Dev. Biol. , vol.53 , pp. 323-334
    • Sasai, N.1    Defossez, P.A.2
  • 14
    • 70349999407 scopus 로고    scopus 로고
    • DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific
    • E.W. Tobi et al. DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific Hum. Mol. Genet. 18 2009 4046 4053
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4046-4053
    • Tobi, E.W.1
  • 15
    • 84879235514 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine: Generation, fate, and genomic distribution
    • L. Shen, and Y. Zhang 5-Hydroxymethylcytosine: generation, fate, and genomic distribution Curr. Opin. Cell Biol. 25 2013 289 296
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 289-296
    • Shen, L.1    Zhang, Y.2
  • 16
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • M. Mellen et al. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system Cell 151 2012 1417 1430
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellen, M.1
  • 17
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • R.M. Kohli, and Y. Zhang TET enzymes, TDG and the dynamics of DNA demethylation Nature 502 2013 472 479
    • (2013) Nature , vol.502 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 18
    • 84876794613 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine and its potential roles in development and cancer
    • G.P. Pfeifer et al. 5-Hydroxymethylcytosine and its potential roles in development and cancer Epigenet Chromatin 6 2013 10
    • (2013) Epigenet Chromatin , vol.6 , pp. 10
    • Pfeifer, G.P.1
  • 19
    • 84874252793 scopus 로고    scopus 로고
    • Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis
    • M.A. Hahn et al. Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis Cell Rep. 3 2013 291 300
    • (2013) Cell Rep. , vol.3 , pp. 291-300
    • Hahn, M.A.1
  • 20
    • 84883156126 scopus 로고    scopus 로고
    • Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function
    • M. Ivanov et al. Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function Genome Biol. 14 2013 R83
    • (2013) Genome Biol. , vol.14 , pp. 83
    • Ivanov, M.1
  • 21
    • 84861990517 scopus 로고    scopus 로고
    • Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome
    • M. Yu et al. Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome Cell 149 2012 1368 1380
    • (2012) Cell , vol.149 , pp. 1368-1380
    • Yu, M.1
  • 22
    • 84861221693 scopus 로고    scopus 로고
    • Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution
    • M.J. Booth et al. Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution Science 336 2012 934 937
    • (2012) Science , vol.336 , pp. 934-937
    • Booth, M.J.1
  • 23
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • A.J. Bannister, and T. Kouzarides Regulation of chromatin by histone modifications Cell Res. 21 2011 381 395
    • (2011) Cell Res. , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 24
    • 66449117658 scopus 로고    scopus 로고
    • Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2
    • K.H. Hansen, and K. Helin Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2 Epigenetics 4 2009 133 138
    • (2009) Epigenetics , vol.4 , pp. 133-138
    • Hansen, K.H.1    Helin, K.2
  • 25
    • 84859174608 scopus 로고    scopus 로고
    • Histone-modifying enzymes: Regulators of developmental decisions and drivers of human disease
    • J.S. Butler et al. Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease Epigenomics 4 2012 163 177
    • (2012) Epigenomics , vol.4 , pp. 163-177
    • Butler, J.S.1
  • 26
    • 33744792310 scopus 로고    scopus 로고
    • Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
    • M.G. Rosenfeld et al. Sensors and signals: a coactivator/corepressor/ epigenetic code for integrating signal-dependent programs of transcriptional response Genes Dev. 20 2006 1405 1428
    • (2006) Genes Dev. , vol.20 , pp. 1405-1428
    • Rosenfeld, M.G.1
  • 27
    • 79960984020 scopus 로고    scopus 로고
    • Shaping the Genome with Non-Coding RNAs
    • X.Q. Wang et al. Shaping the Genome with Non-Coding RNAs Curr. Genomics 12 2011 307 321
    • (2011) Curr. Genomics , vol.12 , pp. 307-321
    • Wang, X.Q.1
  • 28
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • R.A. Gupta et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis Nature 464 2010 1071 1076
    • (2010) Nature , vol.464 , pp. 1071-1076
    • Gupta, R.A.1
  • 29
    • 84887945648 scopus 로고    scopus 로고
    • Regulation of microRNAs by epigenetics and their interplay involved in cancer
    • X. Liu et al. Regulation of microRNAs by epigenetics and their interplay involved in cancer J. Exp. Clin. Cancer Res. 32 2013 96
    • (2013) J. Exp. Clin. Cancer Res. , vol.32 , pp. 96
    • Liu, X.1
  • 30
    • 85027957928 scopus 로고    scopus 로고
    • Perspectives on epigenetics and its relevance to adverse drug reactions
    • M. Kacevska et al. Perspectives on epigenetics and its relevance to adverse drug reactions Clin. Pharmacol. Ther. 89 2011 902 907
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 902-907
    • Kacevska, M.1
  • 31
    • 84866308863 scopus 로고    scopus 로고
    • Epigenetic-dependent regulation of drug transport and metabolism: An update
    • M. Kacevska et al. Epigenetic-dependent regulation of drug transport and metabolism: an update Pharmacogenomics 13 2012 1373 1385
    • (2012) Pharmacogenomics , vol.13 , pp. 1373-1385
    • Kacevska, M.1
  • 32
    • 84869500199 scopus 로고    scopus 로고
    • Epigenomics and interindividual differences in drug response
    • M. Ivanov et al. Epigenomics and interindividual differences in drug response Clin. Pharmacol. Ther. 92 2012 727 736
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 727-736
    • Ivanov, M.1
  • 33
    • 77953126448 scopus 로고    scopus 로고
    • Molecular targets of epigenetic regulation and effectors of environmental influences
    • S. Choudhuri et al. Molecular targets of epigenetic regulation and effectors of environmental influences Toxicol. Appl. Pharmacol. 245 2010 378 393
    • (2010) Toxicol. Appl. Pharmacol. , vol.245 , pp. 378-393
    • Choudhuri, S.1
  • 34
    • 80255134517 scopus 로고    scopus 로고
    • Histone deacetylase 1 is required for carbamazepine-induced CYP3A4 expression
    • Y. Wu et al. Histone deacetylase 1 is required for carbamazepine-induced CYP3A4 expression J. Pharm. Biomed. Anal. 58 2012 78 82
    • (2012) J. Pharm. Biomed. Anal. , vol.58 , pp. 78-82
    • Wu, Y.1
  • 35
    • 84867402748 scopus 로고    scopus 로고
    • DNA methylation dynamics in the hepatic CYP3A4 gene promoter
    • M. Kacevska et al. DNA methylation dynamics in the hepatic CYP3A4 gene promoter Biochimie 94 2012 2338 2344
    • (2012) Biochimie , vol.94 , pp. 2338-2344
    • Kacevska, M.1
  • 36
    • 85027954125 scopus 로고    scopus 로고
    • DNA methylation profiling in the clinic: Applications and challenges
    • H. Heyn, and M. Esteller DNA methylation profiling in the clinic: applications and challenges Nat. Rev. Genet. 13 2012 679 692
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 679-692
    • Heyn, H.1    Esteller, M.2
  • 37
    • 84885215780 scopus 로고    scopus 로고
    • Personalized treatment strategies in glioblastoma: MGMT promoter methylation status
    • N. Thon et al. Personalized treatment strategies in glioblastoma: MGMT promoter methylation status Onco Targets Ther. 6 2013 1363 1372
    • (2013) Onco Targets Ther. , vol.6 , pp. 1363-1372
    • Thon, N.1
  • 38
    • 84866553227 scopus 로고    scopus 로고
    • DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer
    • J. Zhu et al. DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer J. Exp. Clin. Cancer Res. 31 2012 80
    • (2012) J. Exp. Clin. Cancer Res. , vol.31 , pp. 80
    • Zhu, J.1
  • 39
    • 84881416118 scopus 로고    scopus 로고
    • Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy
    • D.M. Janzen et al. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy Cancer Res. 73 2013 4697 4710
    • (2013) Cancer Res. , vol.73 , pp. 4697-4710
    • Janzen, D.M.1
  • 40
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • A.P. Feinberg et al. The epigenetic progenitor origin of human cancer Nat. Rev. Genet. 7 2006 21 33
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 21-33
    • Feinberg, A.P.1
  • 41
    • 77957350610 scopus 로고    scopus 로고
    • Identification of driver and passenger DNA methylation in cancer by epigenomic analysis
    • S. Kalari, and G.P. Pfeifer Identification of driver and passenger DNA methylation in cancer by epigenomic analysis Adv. Genet. 70 2010 277 308
    • (2010) Adv. Genet. , vol.70 , pp. 277-308
    • Kalari, S.1    Pfeifer, G.P.2
  • 42
    • 84855698571 scopus 로고    scopus 로고
    • Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates
    • S.D. Furdas et al. Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates Arch. Pharm. (Weinheim) 345 2012 7 21
    • (2012) Arch. Pharm. (Weinheim) , vol.345 , pp. 7-21
    • Furdas, S.D.1
  • 43
    • 84875867286 scopus 로고    scopus 로고
    • Small-molecular modulators of cancer-associated epigenetic mechanisms
    • Y. Itoh et al. Small-molecular modulators of cancer-associated epigenetic mechanisms Mol. Biosyst. 9 2013 873 896
    • (2013) Mol. Biosyst. , vol.9 , pp. 873-896
    • Itoh, Y.1
  • 45
    • 84886808679 scopus 로고    scopus 로고
    • Chromatin proteins and modifications as drug targets
    • K. Helin, and D. Dhanak Chromatin proteins and modifications as drug targets Nature 502 2013 480 488
    • (2013) Nature , vol.502 , pp. 480-488
    • Helin, K.1    Dhanak, D.2
  • 46
    • 84878635720 scopus 로고    scopus 로고
    • DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer
    • V. Singh et al. DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer Curr. Cancer Drug Targets 13 2013 379 399
    • (2013) Curr. Cancer Drug Targets , vol.13 , pp. 379-399
    • Singh, V.1
  • 47
    • 84862681781 scopus 로고    scopus 로고
    • Epigenetic drug discovery: Targeting DNA methyltransferases
    • J.M. Foulks et al. Epigenetic drug discovery: targeting DNA methyltransferases J. Biomol. Screen. 17 2012 2 17
    • (2012) J. Biomol. Screen. , vol.17 , pp. 2-17
    • Foulks, J.M.1
  • 48
    • 84991408407 scopus 로고    scopus 로고
    • Oral contraceptives modify DNA methylation and monocyte-derived macrophage function
    • I. Campesi et al. Oral contraceptives modify DNA methylation and monocyte-derived macrophage function Biol. Sex Differ. 3 2012 4
    • (2012) Biol. Sex Differ. , vol.3 , pp. 4
    • Campesi, I.1
  • 49
    • 84919866763 scopus 로고    scopus 로고
    • Environmentally induced epigenetic transgenerational inheritance of disease susceptibility
    • 10.1016/j.trsl.2014.02.003
    • E.E. Nilsson, and M.K. Skinner Environmentally induced epigenetic transgenerational inheritance of disease susceptibility Transl. Res. 2014 10.1016/j.trsl.2014.02.003
    • (2014) Transl. Res.
    • Nilsson, E.E.1    Skinner, M.K.2
  • 50
    • 84871961954 scopus 로고    scopus 로고
    • Heart failure: The pivotal role of histone deacetylases
    • R. Hewitson et al. Heart failure: the pivotal role of histone deacetylases Int. J. Biochem. Cell Biol. 45 2013 448 453
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 448-453
    • Hewitson, R.1
  • 51
    • 84870375316 scopus 로고    scopus 로고
    • Histone lysine methylation dynamics: Establishment, regulation, and biological impact
    • J.C. Black et al. Histone lysine methylation dynamics: establishment, regulation, and biological impact Mol. Cell 48 2012 491 507
    • (2012) Mol. Cell , vol.48 , pp. 491-507
    • Black, J.C.1
  • 52
    • 84867393622 scopus 로고    scopus 로고
    • Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum
    • N.A. Malmquist et al. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum Proc. Natl. Acad. Sci. U.S.A. 109 2012 16708 16713
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 16708-16713
    • Malmquist, N.A.1
  • 53
    • 84881192460 scopus 로고    scopus 로고
    • BET bromodomains mediate transcriptional pause release in heart failure
    • P. Anand et al. BET bromodomains mediate transcriptional pause release in heart failure Cell 154 2013 569 582
    • (2013) Cell , vol.154 , pp. 569-582
    • Anand, P.1
  • 54
    • 84865229469 scopus 로고    scopus 로고
    • Small-molecule inhibition of BRDT for male contraception
    • M.M. Matzuk et al. Small-molecule inhibition of BRDT for male contraception Cell 150 2012 673 684
    • (2012) Cell , vol.150 , pp. 673-684
    • Matzuk, M.M.1
  • 55
    • 84857913614 scopus 로고    scopus 로고
    • Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
    • P. Filippakopoulos et al. Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family Bioorg. Med. Chem. 20 2012 1878 1886
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 1878-1886
    • Filippakopoulos, P.1
  • 56
    • 84871879281 scopus 로고    scopus 로고
    • Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice
    • D.Y. Liang et al. Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice J. Pain 14 2013 36 47
    • (2013) J. Pain , vol.14 , pp. 36-47
    • Liang, D.Y.1
  • 57
    • 84855303373 scopus 로고    scopus 로고
    • Histone deacetylases (HDAC)-induced histone modifications in the amygdala: A role in rapid tolerance to the anxiolytic effects of ethanol
    • A.J. Sakharkar et al. Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol Alcohol. Clin. Exp. Res. 36 2012 61 71
    • (2012) Alcohol. Clin. Exp. Res. , vol.36 , pp. 61-71
    • Sakharkar, A.J.1
  • 58
    • 84887080253 scopus 로고    scopus 로고
    • Epigenetic mechanisms of drug addiction
    • E.J. Nestler Epigenetic mechanisms of drug addiction Neuropharmacology 76 2014 259 268
    • (2014) Neuropharmacology , vol.76 , pp. 259-268
    • Nestler, E.J.1
  • 59
    • 84870212393 scopus 로고    scopus 로고
    • Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens
    • H. Sun et al. Morphine epigenomically regulates behavior through alterations in histone H3 lysine 9 dimethylation in the nucleus accumbens J. Neurosci. 32 2012 17454 17464
    • (2012) J. Neurosci. , vol.32 , pp. 17454-17464
    • Sun, H.1
  • 60
    • 84865343936 scopus 로고    scopus 로고
    • Epigenetics of drug abuse: Predisposition or response
    • D.A. Nielsen et al. Epigenetics of drug abuse: predisposition or response Pharmacogenomics 13 2012 1149 1160
    • (2012) Pharmacogenomics , vol.13 , pp. 1149-1160
    • Nielsen, D.A.1
  • 61
    • 84875722622 scopus 로고    scopus 로고
    • Molecular aspects of cancer cell resistance to chemotherapy
    • M. Rebucci, and C. Michiels Molecular aspects of cancer cell resistance to chemotherapy Biochem. Pharmacol. 85 2013 1219 1226
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 1219-1226
    • Rebucci, M.1    Michiels, C.2
  • 62
    • 84859376472 scopus 로고    scopus 로고
    • Molecular pathways: Regulation and therapeutic implications of multidrug resistance
    • K.G. Chen, and B.I. Sikic Molecular pathways: regulation and therapeutic implications of multidrug resistance Clin. Cancer Res. 18 2012 1863 1869
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1863-1869
    • Chen, K.G.1    Sikic, B.I.2
  • 63
    • 84865254848 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to targeted cancer therapies
    • M.R. Lackner et al. Mechanisms of acquired resistance to targeted cancer therapies Future Oncol. 8 2012 999 1014
    • (2012) Future Oncol. , vol.8 , pp. 999-1014
    • Lackner, M.R.1
  • 64
    • 77950809059 scopus 로고    scopus 로고
    • A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
    • S.V. Sharma et al. A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations Cell 141 2010 69 80
    • (2010) Cell , vol.141 , pp. 69-80
    • Sharma, S.V.1
  • 65
    • 84860528199 scopus 로고    scopus 로고
    • Epigenetic resensitization to platinum in ovarian cancer
    • D. Matei et al. Epigenetic resensitization to platinum in ovarian cancer Cancer Res. 72 2012 2197 2205
    • (2012) Cancer Res. , vol.72 , pp. 2197-2205
    • Matei, D.1
  • 66
    • 84884699420 scopus 로고    scopus 로고
    • PANORAMA 2: Panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma
    • P.G. Richardson et al. PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma Blood 122 2013 2331 2337
    • (2013) Blood , vol.122 , pp. 2331-2337
    • Richardson, P.G.1
  • 67
    • 33846938126 scopus 로고    scopus 로고
    • Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans
    • A. Mai et al. Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans Bioorg. Med. Chem. Lett. 17 2007 1221 1225
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 1221-1225
    • Mai, A.1
  • 68
    • 84880079033 scopus 로고    scopus 로고
    • An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake
    • P. Sharma et al. An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake J. Biol. Chem. 288 2013 19429 19440
    • (2013) J. Biol. Chem. , vol.288 , pp. 19429-19440
    • Sharma, P.1
  • 69
    • 84870583474 scopus 로고    scopus 로고
    • Epigenetic editing: Targeted rewriting of epigenetic marks to modulate expression of selected target genes
    • M.L. de Groote et al. Epigenetic editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes Nucleic Acids Res. 40 2012 10596 10613
    • (2012) Nucleic Acids Res. , vol.40 , pp. 10596-10613
    • De Groote, M.L.1
  • 70
    • 77950841042 scopus 로고    scopus 로고
    • Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs
    • B. Malecova, and K.V. Morris Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs Curr. Opin. Mol. Ther. 12 2010 214 222
    • (2010) Curr. Opin. Mol. Ther. , vol.12 , pp. 214-222
    • Malecova, B.1    Morris, K.V.2
  • 71
    • 84860561774 scopus 로고    scopus 로고
    • Epigenetic reprogramming of cancer cells via targeted DNA methylation
    • A.G. Rivenbark et al. Epigenetic reprogramming of cancer cells via targeted DNA methylation Epigenetics 7 2012 350 360
    • (2012) Epigenetics , vol.7 , pp. 350-360
    • Rivenbark, A.G.1
  • 72
    • 84864922025 scopus 로고    scopus 로고
    • Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer
    • S. Stolzenburg et al. Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer Nucleic Acids Res. 40 2012 6725 6740
    • (2012) Nucleic Acids Res. , vol.40 , pp. 6725-6740
    • Stolzenburg, S.1
  • 73
    • 84864513068 scopus 로고    scopus 로고
    • Sangamo's lead zinc-finger therapy flops in diabetic neuropathy
    • M. Eisenstein Sangamo's lead zinc-finger therapy flops in diabetic neuropathy Nat. Biotechnol. 30 2012 121 123
    • (2012) Nat. Biotechnol. , vol.30 , pp. 121-123
    • Eisenstein, M.1
  • 74
    • 84863201964 scopus 로고    scopus 로고
    • Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
    • S. Bultmann et al. Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers Nucleic Acids Res. 40 2012 5368 5377
    • (2012) Nucleic Acids Res. , vol.40 , pp. 5368-5377
    • Bultmann, S.1
  • 75
    • 77952248685 scopus 로고    scopus 로고
    • DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
    • E. Dejeux et al. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response Mol. Cancer 9 2010 68
    • (2010) Mol. Cancer , vol.9 , pp. 68
    • Dejeux, E.1
  • 76
    • 58849143465 scopus 로고    scopus 로고
    • DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy
    • O. Hartmann et al. DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy Clin. Cancer Res. 15 2009 315 323
    • (2009) Clin. Cancer Res. , vol.15 , pp. 315-323
    • Hartmann, O.1
  • 77
    • 84868354895 scopus 로고    scopus 로고
    • BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer
    • O.A. Stefansson et al. BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer Epigenetics 7 2012 1225 1229
    • (2012) Epigenetics , vol.7 , pp. 1225-1229
    • Stefansson, O.A.1
  • 78
    • 79959838676 scopus 로고    scopus 로고
    • GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response
    • B. Chen et al. GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response Cancer Lett. 309 2011 37 45
    • (2011) Cancer Lett. , vol.309 , pp. 37-45
    • Chen, B.1
  • 79
    • 84891785971 scopus 로고    scopus 로고
    • Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
    • M.R. Gilbert et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial J. Clin. Oncol. 31 2013 4085 4091
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4085-4091
    • Gilbert, M.R.1
  • 80
    • 79955509238 scopus 로고    scopus 로고
    • Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer
    • N. Syed et al. Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer Cancer Res. 71 2011 3317 3327
    • (2011) Cancer Res. , vol.71 , pp. 3317-3327
    • Syed, N.1
  • 81
    • 84855755065 scopus 로고    scopus 로고
    • TFAP2E-DKK4 and chemoresistance in colorectal cancer
    • M.P. Ebert et al. TFAP2E-DKK4 and chemoresistance in colorectal cancer New Engl. J. Med. 366 2012 44 53
    • (2012) New Engl. J. Med. , vol.366 , pp. 44-53
    • Ebert, M.P.1
  • 82
    • 80053247020 scopus 로고    scopus 로고
    • GSTP1 DNA methylation and expression status is indicative of 5-aza-2′-deoxycytidine efficacy in human prostate cancer cells
    • K. Chiam et al. GSTP1 DNA methylation and expression status is indicative of 5-aza-2′-deoxycytidine efficacy in human prostate cancer cells PLoS One 6 2011 e25634
    • (2011) PLoS One , vol.6 , pp. 25634
    • Chiam, K.1
  • 83
    • 79960101630 scopus 로고    scopus 로고
    • Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
    • J. Jelinek et al. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia PLoS One 6 2011 e22110
    • (2011) PLoS One , vol.6 , pp. 22110
    • Jelinek, J.1
  • 84
    • 84863572990 scopus 로고    scopus 로고
    • Promoter methylation of RASSF1A modulates the effect of the microtubule-targeting agent docetaxel in breast cancer
    • E.Y. Gil et al. Promoter methylation of RASSF1A modulates the effect of the microtubule-targeting agent docetaxel in breast cancer Int. J. Oncol. 41 2012 611 620
    • (2012) Int. J. Oncol. , vol.41 , pp. 611-620
    • Gil, E.Y.1
  • 85
    • 34548395116 scopus 로고    scopus 로고
    • A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
    • M. Candelaria et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors Ann. Oncol. 18 2007 1529 1538
    • (2007) Ann. Oncol. , vol.18 , pp. 1529-1538
    • Candelaria, M.1
  • 86
    • 84861087737 scopus 로고    scopus 로고
    • Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia
    • E. Cervera et al. Epigenetic therapy with hydralazine and magnesium valproate reverses imatinib resistance in patients with chronic myeloid leukemia Clin. Lymphoma Myeloma Leuk. 12 2012 207 212
    • (2012) Clin. Lymphoma Myeloma Leuk. , vol.12 , pp. 207-212
    • Cervera, E.1
  • 87
    • 79955701085 scopus 로고    scopus 로고
    • Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome
    • M. Candelaria et al. Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome Preliminary results of a phase-II trial. Ann. Hematol. 90 2011 379 387
    • (2011) Preliminary Results of A Phase-II Trial. Ann. Hematol. , vol.90 , pp. 379-387
    • Candelaria, M.1
  • 88
    • 84872316231 scopus 로고    scopus 로고
    • Phase i study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer
    • B.F. Chu et al. Phase I study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small-cell lung cancer Cancer Chemother. Pharmacol. 71 2013 115 121
    • (2013) Cancer Chemother. Pharmacol. , vol.71 , pp. 115-121
    • Chu, B.F.1
  • 89
    • 79958084461 scopus 로고    scopus 로고
    • A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
    • P.N. Munster et al. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer Br. J. Cancer 104 2011 1828 1835
    • (2011) Br. J. Cancer , vol.104 , pp. 1828-1835
    • Munster, P.N.1
  • 90
    • 84860650355 scopus 로고    scopus 로고
    • Efficacy of sodium butyrate adjunct therapy in shigellosis: A randomized, double-blind, placebo-controlled clinical trial
    • R. Raqib et al. Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial BMC Infect. Dis. 12 2012 111
    • (2012) BMC Infect. Dis. , vol.12 , pp. 111
    • Raqib, R.1
  • 91
    • 84864024420 scopus 로고    scopus 로고
    • Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: Results of a phase II study
    • A. Younes et al. Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study J. Clin. Oncol. 30 2012 2197 2203
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2197-2203
    • Younes, A.1
  • 92
    • 84879834815 scopus 로고    scopus 로고
    • Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor
    • D.A. Yardley et al. Randomized phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive breast cancer progressing on treatment with a nonsteroidal aromatase inhibitor J. Clin. Oncol. 31 2013 2128 2135
    • (2013) J. Clin. Oncol. , vol.31 , pp. 2128-2135
    • Yardley, D.A.1
  • 93
    • 82555187781 scopus 로고    scopus 로고
    • Mocetinostat for relapsed classical Hodgkin's lymphoma: An open-label, single-arm, phase 2 trial
    • A. Younes et al. Mocetinostat for relapsed classical Hodgkin's lymphoma: an open-label, single-arm, phase 2 trial Lancet Oncol. 12 2011 1222 1228
    • (2011) Lancet Oncol. , vol.12 , pp. 1222-1228
    • Younes, A.1


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