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Volumn 94, Issue 11, 2012, Pages 2338-2344

DNA methylation dynamics in the hepatic CYP3A4 gene promoter

Author keywords

CYP3A4; DNA methylation; Epigenetics

Indexed keywords

BISULFITE; CCAAT ENHANCER BINDING PROTEIN; CYTOCHROME P450 3A4; CYTOCHROME P450 3A7; HEPATOCYTE NUCLEAR FACTOR 4ALPHA;

EID: 84867402748     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.07.013     Document Type: Article
Times cited : (56)

References (41)
  • 1
    • 0036890399 scopus 로고    scopus 로고
    • The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
    • P.B. Danielson The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans Curr. Drug Metab. 3 2002 561 597
    • (2002) Curr. Drug Metab. , vol.3 , pp. 561-597
    • Danielson, P.B.1
  • 2
    • 0037068964 scopus 로고    scopus 로고
    • Clinical importance of the cytochromes P450
    • D.W. Nebert, and D.W. Russell Clinical importance of the cytochromes P450 Lancet 360 2002 1155 1162
    • (2002) Lancet , vol.360 , pp. 1155-1162
    • Nebert, D.W.1    Russell, D.W.2
  • 3
    • 1942497956 scopus 로고    scopus 로고
    • Cytochromes P450, drugs, and diseases
    • F.P. Guengerich Cytochromes P450, drugs, and diseases Mol. Interv. 3 2003 194 204
    • (2003) Mol. Interv. , vol.3 , pp. 194-204
    • Guengerich, F.P.1
  • 4
  • 5
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • T. Shimada, H. Yamazaki, M. Mimura, Y. Inui, and F.P. Guengerich Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J. Pharmacol. Exp. Ther. 270 1994 414 423
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 6
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region
    • A. Westlind, L. Lofberg, N. Tindberg, T.B. Andersson, and M. Ingelman-Sundberg Interindividual differences in hepatic expression of CYP3A4: relationship to genetic polymorphism in the 5'-upstream regulatory region Biochem. Biophys. Res. Commun. 259 1999 201 205
    • (1999) Biochem. Biophys. Res. Commun. , vol.259 , pp. 201-205
    • Westlind, A.1    Lofberg, L.2    Tindberg, N.3    Andersson, T.B.4    Ingelman-Sundberg, M.5
  • 8
    • 38749088304 scopus 로고    scopus 로고
    • Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice
    • M.A. Felmlee, H.K. Lon, F.J. Gonzalez, and A.M. Yu Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice Drug Metab. Dispos. 36 2008 435 441
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 435-441
    • Felmlee, M.A.1    Lon, H.K.2    Gonzalez, F.J.3    Yu, A.M.4
  • 10
    • 47849122700 scopus 로고    scopus 로고
    • Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals
    • H. Satsu, Y. Hiura, K. Mochizuki, M. Hamada, and M. Shimizu Activation of pregnane X receptor and induction of MDR1 by dietary phytochemicals J. Agric. Food Chem. 56 2008 5366 5373
    • (2008) J. Agric. Food Chem. , vol.56 , pp. 5366-5373
    • Satsu, H.1    Hiura, Y.2    Mochizuki, K.3    Hamada, M.4    Shimizu, M.5
  • 11
    • 33749864288 scopus 로고    scopus 로고
    • Human pregnane X receptor: Genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity
    • P. He, M.H. Court, D.J. Greenblatt, and L.L. von Moltke Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity J. Clin. Pharmacol. 46 2006 1356 1369
    • (2006) J. Clin. Pharmacol. , vol.46 , pp. 1356-1369
    • He, P.1    Court, M.H.2    Greenblatt, D.J.3    Von Moltke, L.L.4
  • 12
    • 23144435169 scopus 로고    scopus 로고
    • Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics
    • J. Lamba, V. Lamba, and E. Schuetz Genetic variants of PXR (NR1I2) and CAR (NR1I3) and their implications in drug metabolism and pharmacogenetics Curr. Drug Metab. 6 2005 369 383
    • (2005) Curr. Drug Metab. , vol.6 , pp. 369-383
    • Lamba, J.1    Lamba, V.2    Schuetz, E.3
  • 13
    • 37549010733 scopus 로고    scopus 로고
    • Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    • J. Lamba, V. Lamba, S. Strom, R. Venkataramanan, and E. Schuetz Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression Drug Metab. Dispos. 36 2008 169 181
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 169-181
    • Lamba, J.1    Lamba, V.2    Strom, S.3    Venkataramanan, R.4    Schuetz, E.5
  • 14
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method
    • V. Ozdemir, W. Kalow, B.K. Tang, A.D. Paterson, S.E. Walker, L. Endrenyi, and A.D. Kashuba Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method Pharmacogenetics 10 2000 373 388
    • (2000) Pharmacogenetics , vol.10 , pp. 373-388
    • Ozdemir, V.1    Kalow, W.2    Tang, B.K.3    Paterson, A.D.4    Walker, S.E.5    Endrenyi, L.6    Kashuba, A.D.7
  • 15
    • 79954517272 scopus 로고    scopus 로고
    • From Waddington's epigenetic landscape to small noncoding RNA: Some important milestones in the history of epigenetics research
    • S. Choudhuri From Waddington's epigenetic landscape to small noncoding RNA: some important milestones in the history of epigenetics research Toxicol. Mech. Methods 21 2011 252 274
    • (2011) Toxicol. Mech. Methods , vol.21 , pp. 252-274
    • Choudhuri, S.1
  • 16
    • 78049441535 scopus 로고    scopus 로고
    • Fine tuning gene expression: The epigenome
    • D. Mohtat, and K. Susztak Fine tuning gene expression: the epigenome Semin. Nephrol. 30 2010 468 476
    • (2010) Semin. Nephrol. , vol.30 , pp. 468-476
    • Mohtat, D.1    Susztak, K.2
  • 17
    • 85027957928 scopus 로고    scopus 로고
    • Perspectives on epigenetics and its relevance to adverse drug reactions
    • M. Kacevska, M. Ivanov, and M. Ingelman-Sundberg Perspectives on epigenetics and its relevance to adverse drug reactions Clin. Pharmacol. Ther. 89 2011 902 907
    • (2011) Clin. Pharmacol. Ther. , vol.89 , pp. 902-907
    • Kacevska, M.1    Ivanov, M.2    Ingelman-Sundberg, M.3
  • 18
    • 33749154491 scopus 로고    scopus 로고
    • Epigenetics of gene expression in human hepatoma cells: Expression profiling the response to inhibition of DNA methylation and histone deacetylation
    • L.O. Dannenberg, and H.J. Edenberg Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation BMC Genomics 7 2006 181
    • (2006) BMC Genomics , vol.7 , pp. 181
    • Dannenberg, L.O.1    Edenberg, H.J.2
  • 19
    • 79951777299 scopus 로고    scopus 로고
    • Involvement of promoter methylation in the regulation of pregnane X receptor in colon cancer cells
    • W. Habano, T. Gamo, J. Terashima, T. Sugai, K. Otsuka, G. Wakabayashi, and S. Ozawa Involvement of promoter methylation in the regulation of pregnane X receptor in colon cancer cells BMC Cancer 11 2011 81
    • (2011) BMC Cancer , vol.11 , pp. 81
    • Habano, W.1    Gamo, T.2    Terashima, J.3    Sugai, T.4    Otsuka, K.5    Wakabayashi, G.6    Ozawa, S.7
  • 20
    • 66049140973 scopus 로고    scopus 로고
    • Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation
    • Y. Li, Y. Cui, S.N. Hart, C.D. Klaassen, and X.B. Zhong Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation Mol. Pharmacol. 75 2009 1171 1179
    • (2009) Mol. Pharmacol. , vol.75 , pp. 1171-1179
    • Li, Y.1    Cui, Y.2    Hart, S.N.3    Klaassen, C.D.4    Zhong, X.B.5
  • 21
    • 16344370634 scopus 로고    scopus 로고
    • Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers
    • C. Rodriguez-Antona, M. Jande, A. Rane, and M. Ingelman-Sundberg Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers Clin. Pharmacol. Ther. 77 2005 259 270
    • (2005) Clin. Pharmacol. Ther. , vol.77 , pp. 259-270
    • Rodriguez-Antona, C.1    Jande, M.2    Rane, A.3    Ingelman-Sundberg, M.4
  • 22
    • 21744451043 scopus 로고    scopus 로고
    • Transcriptional regulation of the human hepatic CYP3A4: Identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein)
    • C.P. Martinez-Jimenez, M.J. Gomez-Lechon, J.V. Castell, and R. Jover Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein) Mol. Pharmacol. 67 2005 2088 2101
    • (2005) Mol. Pharmacol. , vol.67 , pp. 2088-2101
    • Martinez-Jimenez, C.P.1    Gomez-Lechon, M.J.2    Castell, J.V.3    Jover, R.4
  • 23
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module
    • B. Goodwin, E. Hodgson, and C. Liddle The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module Mol. Pharmacol. 56 1999 1329 1339
    • (1999) Mol. Pharmacol. , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 24
    • 0036070955 scopus 로고    scopus 로고
    • Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
    • B. Goodwin, E. Hodgson, D.J. D'Costa, G.R. Robertson, and C. Liddle Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor Mol. Pharmacol. 62 2002 359 365
    • (2002) Mol. Pharmacol. , vol.62 , pp. 359-365
    • Goodwin, B.1    Hodgson, E.2    D'Costa, D.J.3    Robertson, G.R.4    Liddle, C.5
  • 25
    • 34249290413 scopus 로고    scopus 로고
    • Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: Evidence for direct regulation in the intestine
    • H. Tegude, A. Schnabel, U.M. Zanger, K. Klein, M. Eichelbaum, and O. Burk Molecular mechanism of basal CYP3A4 regulation by hepatocyte nuclear factor 4alpha: evidence for direct regulation in the intestine Drug Metab. Dispos. 35 2007 946 954
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 946-954
    • Tegude, H.1    Schnabel, A.2    Zanger, U.M.3    Klein, K.4    Eichelbaum, M.5    Burk, O.6
  • 27
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • A.M. Deaton, and A. Bird CpG islands and the regulation of transcription Genes Dev. 25 2011 1010 1022
    • (2011) Genes Dev. , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 32
    • 34247349605 scopus 로고    scopus 로고
    • Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: Implications for interindividual variability in response to drugs
    • B.L. Urquhart, R.G. Tirona, and R.B. Kim Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs J. Clin. Pharmacol. 47 2007 566 578
    • (2007) J. Clin. Pharmacol. , vol.47 , pp. 566-578
    • Urquhart, B.L.1    Tirona, R.G.2    Kim, R.B.3
  • 34
    • 34547189239 scopus 로고    scopus 로고
    • Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs
    • M. Murray Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs Expert Opin. Drug Metab. Toxicol. 3 2007 185 196
    • (2007) Expert Opin. Drug Metab. Toxicol. , vol.3 , pp. 185-196
    • Murray, M.1
  • 35
    • 4444278991 scopus 로고    scopus 로고
    • The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes
    • A. Parkinson, D.R. Mudra, C. Johnson, A. Dwyer, and K.M. Carroll The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes Toxicol. Appl. Pharmacol. 199 2004 193 209
    • (2004) Toxicol. Appl. Pharmacol. , vol.199 , pp. 193-209
    • Parkinson, A.1    Mudra, D.R.2    Johnson, C.3    Dwyer, A.4    Carroll, K.M.5
  • 36
    • 0028175687 scopus 로고
    • Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver
    • J.D. Schuetz, D.L. Beach, and P.S. Guzelian Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver Pharmacogenetics 4 1994 11 20
    • (1994) Pharmacogenetics , vol.4 , pp. 11-20
    • Schuetz, J.D.1    Beach, D.L.2    Guzelian, P.S.3
  • 37
    • 0030750270 scopus 로고    scopus 로고
    • Expression of CYP3A in the human liver-evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth
    • D. Lacroix, M. Sonnier, A. Moncion, G. Cheron, and T. Cresteil Expression of CYP3A in the human liver-evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth Eur. J. Biochem. 247 1997 625 634
    • (1997) Eur. J. Biochem. , vol.247 , pp. 625-634
    • Lacroix, D.1    Sonnier, M.2    Moncion, A.3    Cheron, G.4    Cresteil, T.5
  • 40
    • 33646079393 scopus 로고    scopus 로고
    • New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology
    • J.C. Stevens New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology Drug Discov. Today 11 2006 440 445
    • (2006) Drug Discov. Today , vol.11 , pp. 440-445
    • Stevens, J.C.1
  • 41
    • 43049154812 scopus 로고    scopus 로고
    • The ontogeny of drug metabolism enzymes and implications for adverse drug events
    • R.N. Hines The ontogeny of drug metabolism enzymes and implications for adverse drug events Pharmacol. Ther. 118 2008 250 267
    • (2008) Pharmacol. Ther. , vol.118 , pp. 250-267
    • Hines, R.N.1


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