Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 40-50

  Lu, Chia Yang ^a   Yang, Ya Chen ^b   Li, Chien Chun ^c,d   Liu, Kai Li ^c,d   Lii, Chong Kuei ^a,b   Chen, Haw Wen ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Activator protein 1 (AP 1); Glutamate cysteine ligase modifier subunit (GCLM); Heme oxygenase 1 (HO 1); NADPH oxidase; Nuclear factor erythroid 2 related factor 2 (Nrf2)

Indexed keywords

ACETYLCYSTEINE; ANDROGRAPHOLIDE; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE MODIFIER SUBUNIT; GLUTATHIONE; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; NADPH OXIDASE SUBUNIT P47; NADPH OXIDASE SUBUNIT P67; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ADHESION; CELL LEVEL; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HL 60 CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INTRACELLULAR SIGNALING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; UPREGULATION;

ACTIVATOR PROTEIN 1 (AP-1); GLUTAMATE CYSTEINE LIGASE MODIFIER SUBUNIT (GCLM); HEME OXYGENASE 1 (HO-1); NADPH OXIDASE; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 (NRF2);

CELL ADHESION; CELLS, CULTURED; DITERPENES; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE-1; HL-60 CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84905494513     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.06.024     Document Type: Article

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