Superoxide, H2O2, and iron are required for TNF-α-induced MCP-1 gene expression in endothelial cells: Role of Rac1 and NADPH oxidase

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 286, Issue 3 55-3, 2004, Pages

  Chen, Xi Lin ^a,b   Zhang, Qiang ^b   Zhao, Ruozhi ^b   Medford, Russell M ^a,b  

^a AtheroGenics Inc   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cells; Monocyte chemoattractant protein 1; Reactive oxygen species; Tumor necrosis factor

Indexed keywords

5,10,15,20 TETRAKIS(4 SULFONATOPHENYL)PORPHYRINATOIRON CHLORIDE; ADENOVIRUS VECTOR; CATALASE; DEFERIPRONE; DIMETHYL SULFOXIDE; DIMETHYLTHIOUREA; DIPHENYLIODONIUM SALT; FERROUS CHLORIDE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXYNITRITE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 1,3-DIMETHYLTHIOUREA; 5,10,15,20 TETRAKIS(4 SULFONATOPHENYL)PORPHYRINATO IRON(III) CHLORIDE; 5,10,15,20-TETRAKIS(4-SULFONATOPHENYL)PORPHYRINATO IRON(III) CHLORIDE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; HYDROXIDE; HYDROXIDE ION; IRON CHELATING AGENT; MESSENGER RNA; METALLOPORPHYRIN; PYRIDONE DERIVATIVE; SCAVENGER; THIOUREA;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NORTHERN BLOTTING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; AORTA; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY; PROMOTER REGION; VASCULAR ENDOTHELIUM;

ANTINEOPLASTIC AGENTS; AORTA; CATALASE; CELLS, CULTURED; CHEMOKINE CCL2; DIMETHYL SULFOXIDE; ENDOTHELIUM, VASCULAR; FREE RADICAL SCAVENGERS; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; HYDROXIDES; IRON; IRON CHELATING AGENTS; METALLOPORPHYRINS; NADPH OXIDASE; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PYRIDONES; RAC1 GTP-BINDING PROTEIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SUPEROXIDES; THIOUREA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1642568624     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00716.2003     Document Type: Article

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