Methyl ketone oxime esters as nucleophilic coupling partners in Pd-catalyzed C-H alkylation and application in the synthesis of isoquinolines

Journal of Organic Chemistry

Volumn 79, Issue 15, 2014, Pages 7041-7050

  Zhang, Zhi Wei ^a,b   Lin, Aijun ^a   Yang, Jiong ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ACTIVATION ANALYSIS; ALKYLATION; AROMATIC COMPOUNDS; AROMATIZATION; CATALYSIS; CHEMICAL ACTIVATION; ESTERS; REACTION INTERMEDIATES;

C-C BOND FORMATION; C-H FUNCTIONALIZATION; CARBONYL DERIVATIVES; INTRAMOLECULAR CONDENSATION; MECHANISTIC STUDIES; POINT OF DEPARTURES; REDUCTIVE ELIMINATION; TAUTOMERIZATIONS;

PALLADIUM COMPOUNDS;

1 ETHYL 3 (2 METHOXYPHENYL)ISOQUINOLINE; 1 ETHYL 3 (3 METHOXYPHENYL)ISOQUINOLINE; 1 ETHYL 3 (4 (TRIFLUOROMETHYL)PHENYL)ISOQUINOLINE; 1 ETHYL 3 (4 FLUOROPHENYL)ISOQUINOLINE; 1 ETHYL 3 (4 METHOXYPHENYL)ISOQUINOLINE; 1 ETHYL 3 (4 TOLYL)ISOQUINOLINE; 1 ETHYL 3 PHENYLISOQUINOLINE; 1 ISOPROPYL 3 (3 METHOXYPHENYL)ISOQUINOLINE; 1 ISOPROPYL 3 (4 TOLYL)ISOQUINOLINE; 1 ISOPROPYL 3 PHENYLISOQUINOLINE; 1 PHENYL 3 (PROP 1 EN 2 YL)ISOQUINOLINE; 1,3 DIPHENYLISOQUINOLINE; 2 (2 ACETYLPHENYL) 1 PHENYLETHAN 1 ONE; 2,2 DIMETHYL 1 (((1 (2 (2 OXO 2 PHENYLETHYL)PHENYL)ETHYLIDENE)AMINO)OXY)PROPAN 1 ONE O PIVALOYL OXIME; 3 (2 CHLOROPHENYL) 1 ETHYLISOQUINOLINE; 3 (3 CHLOROPHENYL) 1 ETHYLISOQUINOLINE; 3 (4 BROMOPHENYL) 1 ETHYLISOQUINOLINE; 3 (4 CHLOROPHENYL) 1 ETHYLISOQUINOLINE; 3 (4 CHLOROPHENYL) 1 PHENYLISOQUINOLINE; 3 (4 FLUOROPHENYL) 1 PHENYLISOQUINOLINE; CARBONYL DERIVATIVE; ESTER; ISOQUINOLINE DERIVATIVE; METHYL 1 ETHYLISOQUINOLINE 3 CARBOXYLATE; METHYL 1 METHYLISOQUINOLINE 3 CARBOXYLATE; METHYL 1 PHENYLISOQUINOLINE 3 CARBOXYLATE; METHYL 4 (1 ETHYLISOQUINOLIN 3 YL)BENZOATE; METHYL KETONE OXIME ESTER; PALLADIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CONTROLLED STUDY; DECOMPOSITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; INTRAMOLECULAR CONDENSATION; NUCLEOPHILICITY; REDUCTION; TAUTOMERIZATION;

EID: 84905389486     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo5010586     Document Type: Article

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