Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases

Chemico-Biological Interactions

Volumn 220, Issue , 2014, Pages 231-240

  Ruan, Jian Qing ^a   Yan, Ru ^a  

^a Macau University of Science and Technology   (Macao)

Author keywords

Calycosin; Glucuronidation; Metabolism; Regioselectivity; UDP glucuronosyltransferases

Indexed keywords

BILIRUBIN; CALYCOSIN; CALYCOSIN 3' GLUCURONIDE; CALYCOSIN 7 GLUCURONIDE; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; ISOFLAVONE; PROPOFOL; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE; GLUCURONIC ACID; ISOFLAVONE DERIVATIVE; RECOMBINANT PROTEIN; UDP-GLUCURONOSYLTRANSFERASE 1A9;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL FRACTIONATION; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG ISOLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SULFATION; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; LIVER MICROSOME METABOLISM; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; VELOCITY; HYDROXYLATION; LIVER MICROSOME; METABOLISM; STEREOISOMERISM;

GLUCURONATES; GLUCURONOSYLTRANSFERASE; HUMANS; HYDROXYLATION; ISOFLAVONES; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES, LIVER; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 84905193097     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.07.003     Document Type: Article

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