Effect of long-term intervention of soy isoflavones on bone mineral density in women: A meta-analysis of randomized controlled trials

Bone

Volumn 44, Issue 5, 2009, Pages 948-953

  Liu, Jing ^a   Ho, Suzanne C ^b   Su, Yi xiang ^a   Chen, Wei qing ^a   Zhang, Cai xia ^a   Chen, Yu ming ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Bone mineral density; Isoflavones; Meta analysis; Soy; Women

Indexed keywords

ISOFLAVONE; SOYBEAN PROTEIN;

AGING; ARTICLE; BONE DENSITY; BONE MINERAL; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG DOSE COMPARISON; DUAL ENERGY X RAY ABSORPTIOMETRY; ETHNIC GROUP; FEMALE; FEMUR NECK; HIP; HUMAN; LUMBAR SPINE; MENOPAUSE; META ANALYSIS; OSTEOPOROSIS; RACE DIFFERENCE; SOYBEAN; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ADULT; AGED; BONE DENSITY; FEMALE; FEMUR NECK; HIP JOINT; HUMANS; ISOFLAVONES; LUMBAR VERTEBRAE; MIDDLE AGED; RANDOMIZED CONTROLLED TRIALS AS TOPIC; YOUNG ADULT;

EID: 63449093711     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.12.020     Document Type: Article

References (38)

1. Andersen S.J. Osteoporosis in the older woman. Clin. Obstet. Gynecol. 50 (2007) 752-766
2. Qaseem A., Snow V., Shekelle P., Hopkins Jr. R., Forciea M.A., and Owens D.K. Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. Ann. Intern. Med. 149 (2008) 404-415
3. Setchell K.D. Soy isoflavones: benefits and risks from nature's selective estrogen receptor modulators (SERMs). J. Am. Coll. Nutr. 20 (2001) 354S-362S discussion 81S-83S
4. Knight D.C., and Eden J.A. A review of the clinical effects of phytoestrogens. Obstet. Gynecol. 87 (1996) 897-904
5. Anderson J.J., Chen X., Boass A., Symons M., Kohlmeier M., Renner J.B., et al. Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J. Am. Coll. Nutr. 21 (2002) 388-393
6. Chen Y.M., Ho S.C., Lam S.S., Ho S.S., and Woo J.L. Soy isoflavones have a favorable effect on bone loss in Chinese postmenopausal women with lower bone mass: a double-blind, randomized, controlled trial. J. Clin. Endocrinol. Metab. 88 (2003) 4740-4747
7. Kreijkamp-Kaspers S., Kok L., Grobbee D.E., de Haan E.H., Aleman A., Lampe J.W., and van der Schouw Y.T. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292 (2004) 65-74
8. Gallagher J.C., Satpathy R., Rafferty K., and Haynatzka V. The effect of soy protein isolate on bone metabolism. Menopause 11 (2004) 290-298
9. Lydeking-Olsen E., Beck-Jensen J.E., Setchell K.D., and Holm-Jensen T. Soymilk or progesterone for prevention of bone loss: a 2 year randomized, placebo-controlled trial. Eur. J. Nutr. 43 (2004) 246-257
10. Arjmandi B.H., Lucas E.A., Khalil D.A., Devareddy L., Smith B.J., McDonald J., et al. One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women. Nutr. J. 4 (2005) 8
11. Huang H.Y., Yang H.P., Yang H.T., Yang T.C., Shieh M.J., and Huang S.Y. One-year soy isoflavone supplementation prevents early postmenopausal bone loss but without a dose-dependent effect. J. Nutr. Biochem. 17 (2006) 509-517
12. Wu J., Oka J., Tabata I., Higuchi M., Toda T., Fuku N., et al. Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial. J. Bone Miner. Res. 21 (2006) 780-789
13. Newton K.M., LaCroix A.Z., Levy L., Li S.S., Qu P., Potter J.D., et al. Soy protein and bone mineral density in older men and women: a randomized trial. Maturitas 55 (2006) 270-277
14. Brink E., Coxam V., Robins S., Wahala K., Cassidy A., and Branca F. Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study. Am. J. Clin. Nutr. 87 (2008) 761-770
15. Potter S.M., Baum J.A., Teng H., Stillman R.J., Shay N.F., and Erdman Jr. J.W. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am. J. Clin. Nutr. 68 (1998) 1375S-1379S
16. Alekel D.L., Germain A.S., Peterson C.T., Hanson K.B., Stewart J.W., and Toda T. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am. J. Clin. Nutr. 72 (2000) 844-852
17. Harkness L.S., Fiedler K., Sehgal A.R., Oravec D., and Lerner E. Decreased bone resorption with soy isoflavone supplementation in postmenopausal women. J. Women's Health 13 (2004) 1000-1007
18. Ye Y.B., Tang X.Y., Verbruggen M.A., and Su Y.X. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial. Eur. J. Nutr. 45 (2006) 327-334
19. Evans E.M., Racette S.B., Van Pelt R.E., Peterson L.R., and Villareal D.T. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause 14 (2007) 481-488
20. Uesugi T., Toda T., Okuhira T., and Chen J.T. Evidence of estrogenic effect by the three-month-intervention of isoflavone on vaginal maturation and bone metabolism in early postmenopausal women. Endocr. J. 50 (2003) 613-619
21. Ma D.F., Qin L.Q., Wang P.Y., and Katoh R. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clin. Nutr. 27 (2008) 57-64
22. Jadad A.R., Moore R.A., Carroll D., Jenkinson C., Reynolds D.J., Gavaghan D.J., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control. Clin. Trials 17 (1996) 1-12
23. Martyn-St James M., and Carroll S. High-intensity resistance training and postmenopausal bone loss: a meta-analysis. Osteoporos. Int. 17 (2006) 1225-1240
24. In: Higgins J.P., and Green S. (Eds). Cochrane handbook for systematic reviews of interventions 4.2.6 [updated September 2006]. The Cochrane Library, Issue 4, 2006 (2006), John Wiley and Sons, Ltd., Chichester, UK
25. Higgins J.P., Thompson S.G., Deeks J.J., and Altman D.G. Measuring inconsistency in meta-analyses. BMJ 327 (2003) 557-560
26. DerSimonian R., and Laird N. Meta-analysis in clinical trials. Control. Clin. Trials 7 (1986) 177-188
27. Egger M., Davey Smith G., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315 (1997) 629-634
28. Rosenberg M.S. The file-drawer problem revisited: a general weighted method for calculating fail-safe numbers in meta-analysis. Evolution 59 (2005) 464-468
29. Chen Y.M., Ho S.C., Lam S.S., Ho S.S., and Woo J.L. Beneficial effect of soy isoflavones on bone mineral content was modified by years since menopause, body weight, and calcium intake: a double-blind, randomized, controlled trial. Menopause 11 (2004) 246-254
30. Chiechi L.M., Secreto G., D'Amore M., Fanelli M., Venturelli E., Cantatore F., et al. Efficacy of a soy rich diet in preventing postmenopausal osteoporosis: the Menfis randomized trial. Maturitas 42 (2002) 295-300
31. Bunout D., Barrera G., Leiva L., Gattas V., de la Maza M.P., Haschke F., et al. Effect of a nutritional supplementation on bone health in Chilean elderly subjects with femoral osteoporosis. J. Am. Coll. Nutr. 25 (2006) 170-177
32. Wu J., Oka J., Higuchi M., Tabata I., Toda T., Fujioka M., et al. Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial. Metabolism 55 (2006) 423-433
33. Heaney R.P. The bone remodeling transient: interpreting interventions involving bone-related nutrients. Nutr. Rev. 59 (2001) 327-334
34. Ma D.F., Qin L.Q., Wang P.Y., and Katoh R. Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials. Eur. J. Clin. Nutr. 62 (2008) 155-161
35. Ishida H., Uesugi T., Hirai K., Toda T., Nukaya H., Yokotsuka K., et al. Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet. Biol. Pharm. Bull. 21 (1998) 62-66
36. Fanti P., Monier-Faugere M.C., Geng Z., Schmidt J., Morris P.E., Cohen D., et al. The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos. Int. 8 (1998) 274-281
37. Arjmandi B.H., Khalil D.A., Smith B.J., Lucas E.A., Juma S., Payton M.E., et al. Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion. J. Clin. Endocrinol. Metab. 88 (2003) 1048-1054
38. Hertrampf T., Gruca M.J., Seibel J., Laudenbach U., Fritzemeier K.H., and Diel P. The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity. Bone 40 (2007) 1529-1535