Profiling and identification of the metabolites of calycosin in rat hepatic 9000×g supernatant incubation system and the metabolites of calycosin-7-O-β-d-glucoside in rat urine by HPLC-DAD-ESI-IT-TOF-MSn technique

Journal of Pharmaceutical and Biomedical Analysis

Volumn 70, Issue , 2012, Pages 425-439

  Zhang, Ya Zhou ^a   Xu, Feng ^a   Dong, Jing ^b   Liang, Jing ^a   Hashi, Yuki ^b   Shang, Ming Ying ^a   Yang, Dong Hui ^a   Wang, Xuan ^a   Cai, Shao Qing ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Shimadzu (China) Co Ltd   (China)

Author keywords

Calycosin; Calycosin 7 O d glucoside; Hepatic 9000 g supernatant; HPLC DAD ESI IT TOF MSn; Isoflavonoid; Metabolite profiling

Indexed keywords

7,3',4' TRIHYDROXYISOFLAVONE; 8 HYDROXYCALYCOSIN; AGLYCONE; CALYCOSIN; CALYCOSIN 7 O BETA DEXTRO GLUCOSIDE DERIVATIVE; DAIDZEIN; DRUG METABOLITE; FORMONONETIN; ISOFLAVONOID; PRATENSEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DEMETHYLATION; DIMERIZATION; DRUG ACTIVITY; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGENATION; HYDROXYLATION; IN VIVO STUDY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUPERNATANT; TIME OF FLIGHT MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEALKYLATION; DIMERIZATION; DRUGS, CHINESE HERBAL; GLUCOSIDES; GLYCOSYLATION; HYDROXYLATION; ISOFLAVONES; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; URINALYSIS;

EID: 84866261352     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.06.006     Document Type: Article

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