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Volumn 19, Issue 1, 2014, Pages 177-203

A comparative study on the metabolism of epimedium koreanum Nakai-Prenylated Flavonoids in rats by an intestinal Enzyme (Lactase Phlorizin Hydrolase) and Intestinal Flora

Author keywords

Epimedium; Intestinal flora; Lactase phlorizin hydrolase; Metabolite; Prenylated flavonoids

Indexed keywords


EID: 84893089975     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules19010177     Document Type: Article
Times cited : (53)

References (21)
  • 1
    • 84870228281 scopus 로고    scopus 로고
    • Enhancement of epimedium fired with suet oil based on in vivo formation of self-Assembled flavonoid compound nanomicelles
    • Cui, L.; Zhang, Z.H.; Tan, X.B.; Wei, Y.J.; Jin, X.; Jia, X.B. Enhancement of Epimedium fired with suet oil based on in vivo formation of self-Assembled flavonoid compound nanomicelles. Molecules 2012, 17, 12984-12996.
    • (2012) Molecules , vol.17 , pp. 12984-12996
    • Cui, L.1    Zhang, Z.H.2    Tan, X.B.3    Wei, Y.J.4    Jin, X.5    Jia, X.B.6
  • 2
    • 84893083206 scopus 로고    scopus 로고
    • Research progress in metabolites of active constitutes from epimedii herbal
    • Han, H.; Shan, Q.; Zhou, F.J.; Zhang, X.X.; Hou, W.B. Research progress in metabolites of active constitutes from Epimedii Herbal. Drugs Clin. 2013, 28, 78-81.
    • (2013) Drugs Clin. , vol.28 , pp. 78-81
    • Han, H.1    Shan, Q.2    Zhou, F.J.3    Zhang, X.X.4    Hou, W.B.5
  • 3
    • 77649112643 scopus 로고    scopus 로고
    • Development of a est dataset and characterization of est-ssrs in traditional chinese medicinal plant epimedum sagiitatum (sieb. Et zucc.) maxim
    • Zeng, S.H.; Gong, X.; Guo, J.; Fei, Z.J.; Xu, Y.Q.; Roe, B.A.; Wang, Y. Development of a EST dataset and characterization of EST-SSRs in traditional Chinese medicinal plant, Epimedum sagiitatum (Sieb. Et Zucc.) Maxim. BMC Genomics 2010, 11, 94.
    • (2010) BMC Genomics , vol.11 , pp. 94
    • Zeng, S.H.1    Gong, X.2    Guo, J.3    Fei, Z.J.4    Xu, Y.Q.5    Roe, B.A.6    Wang, Y.7
  • 4
    • 84893068863 scopus 로고    scopus 로고
    • Simultaneous determination of five main flavonoids in herb epimedii from different species by rp-hplc-uv
    • Chen, Y.; Zhao, Y.H.; Jia, X.B.; Ding, A.W. Simultaneous determination of five main flavonoids in herb Epimedii from different species by RP-HPLC-UV. Chin. Pharm. 2008, 19, 431-432.
    • (2008) Chin. Pharm. , vol.19 , pp. 431-432
    • Chen, Y.1    Zhao, Y.H.2    Jia, X.B.3    Ding, A.W.4
  • 5
    • 84879171691 scopus 로고    scopus 로고
    • Analysis and quality evaluation of five falvonoids in folium and rhizome of epimedii folium
    • Guo, Q.; Wu, X.Y.; Ning, Q.; Lv, X. Analysis and quality evaluation of five falvonoids in folium and rhizome of Epimedii Folium. Chin. Tradit. Herb. Drugs 2011, 42, 2028-2035.
    • (2011) Chin. Tradit. Herb. Drugs , vol.42 , pp. 2028-2035
    • Guo, Q.1    Wu, X.Y.2    Ning, Q.3    Lv, X.4
  • 6
    • 84876108451 scopus 로고    scopus 로고
    • Variation of epimedins a-c and icariin in ten representative populations of epimedium brevicornu maxim., and implications for utilization
    • Xu, Y.; Li, Z.; Yuan, L.; Zhang, X.; Lu, D.; Huang, H.; Wang, Y. Variation of epimedins A-C and icariin in ten representative populations of Epimedium brevicornu Maxim., and implications for utilization. Chem. Biodivers. 2013, 10, 711-721.
    • (2013) Chem. Biodivers. , vol.10 , pp. 711-721
    • Xu, Y.1    Li, Z.2    Yuan, L.3    Zhang, X.4    Lu, D.5    Huang, H.6    Wang, Y.7
  • 7
    • 79952126058 scopus 로고    scopus 로고
    • Rloe of intestinal hydrolase in the absorption of prenylated flavonoids present in yinyanghuo
    • Chen, Y.; Wang, J.Y.; Jia, X.B.; Tan, X.B.; Hu, M. Rloe of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. Molecules 2011, 16, 1336-1348.
    • (2011) Molecules , vol.16 , pp. 1336-1348
    • Chen, Y.1    Wang, J.Y.2    Jia, X.B.3    Tan, X.B.4    Hu, M.5
  • 8
    • 33749362515 scopus 로고    scopus 로고
    • Flavonoids derived from herbal epimedium brevicornum maxim prevent ovx-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption
    • Zhang, G.; Qi, L.; Hung, W.Y.; Shi, Y.Y.; Leung, P.C.; Yeung, H.Y.; Leung, K.S. Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption. Bone 2006, 38, 818-825.
    • (2006) Bone , vol.38 , pp. 818-825
    • Zhang, G.1    Qi, L.2    Hung, W.Y.3    Shi, Y.Y.4    Leung, P.C.5    Yeung, H.Y.6    Leung, K.S.7
  • 9
    • 84865223421 scopus 로고    scopus 로고
    • Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the chinese medicine herba epimedii in rats
    • Chang, Q.; Wang, G.N.; Li, Y.; Zhang, L.; You, C.; Zheng, Y. Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats. Phytomed 2012, 19, 1024-1028.
    • (2012) Phytomed , vol.19 , pp. 1024-1028
    • Chang, Q.1    Wang, G.N.2    Li, Y.3    Zhang, L.4    You, C.5    Zheng, Y.6
  • 10
    • 84855178035 scopus 로고    scopus 로고
    • Metabolism of epimedium-derived flavonoid glycosides in intestinal flora of rabbits and its inhibition by gluconolactone
    • Yao, Z.H.; Liu, M.Y.; Dai, Y.; Zhang, Y.; Qin, Z.F.; Tu, F.J.; Yao, X.S. Metabolism of Epimedium-derived flavonoid glycosides in intestinal flora of rabbits and its inhibition by gluconolactone. Chin. J. Nat. Med. 2011, 9, 461-465.
    • (2011) Chin. J. Nat. Med. , vol.9 , pp. 461-465
    • Yao, Z.H.1    Liu, M.Y.2    Dai, Y.3    Zhang, Y.4    Qin, Z.F.5    Tu, F.J.6    Yao, X.S.7
  • 11
    • 27144451327 scopus 로고    scopus 로고
    • Studies on the metabolism of icariin by intestinal bacteria part i: The transformation of icariin by intestinal flora
    • Liu, T.H.; Wang, Y.; Wang, B.X.; Wu, L.J. Studies on the metabolism of icariin by intestinal bacteria part I: The transformation of icariin by intestinal flora. Chin. Tradit. Herb. Drugs 2000, 31, 834-836.
    • (2000) Chin. Tradit. Herb. Drugs , vol.31 , pp. 834-836
    • Liu, T.H.1    Wang, Y.2    Wang, B.X.3    Wu, L.J.4
  • 12
    • 61449086280 scopus 로고    scopus 로고
    • Determination of breviflavone a and b in epimedium herbs with liquid chromatography-tandem mass spectrometry
    • Hong, X.; Wang, X.C.; Yong, E.L.; Gong, Y.H. Determination of breviflavone A and B in Epimedium herbs with liquid chromatography-tandem mass spectrometry. J. Pharm. Biomed. Anal. 2009, 49, 853-857.
    • (2009) J. Pharm. Biomed. Anal. , vol.49 , pp. 853-857
    • Hong, X.1    Wang, X.C.2    Yong, E.L.3    Gong, Y.H.4
  • 13
    • 84893103844 scopus 로고    scopus 로고
    • Research advanced in pharmacological effects of icarrin
    • Gao, M.T.; Ma, F.F.; Wu, S.H.; Luo, T.S.; Zhang, C.G. Research advanced in pharmacological effects of icarrin. Med. Plant 2013, 4, 79-82.
    • (2013) Med. Plant , vol.4 , pp. 79-82
    • Gao, M.T.1    Ma, F.F.2    Wu, S.H.3    Luo, T.S.4    Zhang, C.G.5
  • 14
    • 84875110730 scopus 로고    scopus 로고
    • A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry
    • Jin, Y.; Wu, C.S.; Zhang, J.L.; Li, Y.F. A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry. Anal. Chim. Acta 2013, 768, 111-117.
    • (2013) Anal. Chim. Acta , vol.768 , pp. 111-117
    • Jin, Y.1    Wu, C.S.2    Zhang, J.L.3    Li, Y.F.4
  • 15
    • 84870447931 scopus 로고    scopus 로고
    • Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling
    • Ming, L.G.; Chen, K.M.; Xian, C.J. Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. J. Cell. Physiol. 2013, 228, 513-521.
    • (2013) J. Cell. Physiol. , vol.228 , pp. 513-521
    • Ming, L.G.1    Chen, K.M.2    Xian, C.J.3
  • 16
    • 0038476614 scopus 로고    scopus 로고
    • Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia
    • Kuokkanen, M.; Enattah, N.S.; Oksanen, A.; Savilahti, E.; Orpana, A.; Järvelä, I. Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 2003, 52, 647-652.
    • (2003) Gut , vol.52 , pp. 647-652
    • Kuokkanen, M.1    Enattah, N.S.2    Oksanen, A.3    Savilahti, E.4    Orpana, A.5    Järvelä, I.6
  • 17
    • 0037354625 scopus 로고    scopus 로고
    • Hydrolysis by lac-tase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro
    • Wilkinson, A.P.; Gee, J.M.; Dupont, M.S.; Needs, P.W.; Mellon, F.A.; Williamson, G.; Johnson, I.T. Hydrolysis by lac-tase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro. Xenobiotica 2003, 33, 255-264.
    • (2003) Xenobiotica , vol.33 , pp. 255-264
    • Wilkinson, A.P.1    Gee, J.M.2    Dupont, M.S.3    Needs, P.W.4    Mellon, F.A.5    Williamson, G.6    Johnson, I.T.7
  • 18
    • 84860646179 scopus 로고    scopus 로고
    • Hesperidin a citrus bioflavonoid modulates hepatic biotransformation enzymes and enhances intrinsic antioxidants in experimental breast cancer rats challenged with 7, 12-dimethylbenz (a) anthracene
    • Nandakumar, N.; Balasubramanian, M.P. Hesperidin a citrus bioflavonoid modulates hepatic biotransformation enzymes and enhances intrinsic antioxidants in experimental breast cancer rats challenged with 7, 12-dimethylbenz (a) anthracene. J. Exp. Ther. Oncol. 2012, 9, 321-335.
    • (2012) J. Exp. Ther. Oncol. , vol.9 , pp. 321-335
    • Nandakumar, N.1    Balasubramanian, M.P.2
  • 19
    • 11844285673 scopus 로고    scopus 로고
    • Absorption bioavailability, and metabolism of flavonoids
    • Peter, C.H. Absorption, bioavailability, and metabolism of flavonoids. Pharm. Biol. 2004, 42, 74-83.
    • (2004) Pharm. Biol. , vol.42 , pp. 74-83
    • Peter, C.H.1
  • 20
    • 0030067441 scopus 로고    scopus 로고
    • A purgative action of barbaloin is induced by eubacterium sp. Strain bar, a human intestinal anaerobic, capable of transforming barbaloin to aloe emodin anthrone
    • Akao, T.; Che, Q.M.; Kyoichi, K.; Hattori, M.; Namba, T. A purgative action of barbaloin is induced by Eubacterium sp. Strain BAR, a human intestinal anaerobic, capable of transforming barbaloin to aloe emodin anthrone. Biol. Pharm. Bull. 1996, 19, 136-138.
    • (1996) Biol. Pharm. Bull. , vol.19 , pp. 136-138
    • Akao, T.1    Che, Q.M.2    Kyoichi, K.3    Hattori, M.4    Namba, T.5
  • 21
    • 0037373381 scopus 로고    scopus 로고
    • Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase
    • Sesink, A.L.; Arts, I.C.; Faassen-Peters, M.; Hollman, P.C. Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolase. J. Nutr. 2003, 133, 773-776.
    • (2003) J. Nutr. , vol.133 , pp. 773-776
    • Sesink, A.L.1    Arts, I.C.2    Faassen-Peters, M.3    Hollman, P.C.4


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