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Volumn 5, Issue 13, 2014, Pages 4581-4602

Oncogenic nexus of cancerous inhibitor of protein phosphatase 2A (CIP2A): An oncoprotein with many hands

Author keywords

Biomarkers; c MYC; Cancers; CIP2A; PP2A; Prognosis

Indexed keywords

ANTINEOPLASTIC AGENT; CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; MYC PROTEIN; ONCOPROTEIN; UNCLASSIFIED DRUG; AUTOANTIGEN; KIAA1524 PROTEIN, HUMAN; MEMBRANE PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN BINDING; TUMOR MARKER;

EID: 84904963010     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2127     Document Type: Article
Times cited : (62)

References (159)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA. The hallmarks of cancer. Cell. 2000; 100(1):57-70.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 41549090369 scopus 로고    scopus 로고
    • Multiple pathways regulated by the tumor suppressor PP2A in transformation
    • Westermarck J and Hahn WC. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends in molecular medicine. 2008; 14(4):152-160.
    • (2008) Trends in molecular medicine , vol.14 , Issue.4 , pp. 152-160
    • Westermarck, J.1    Hahn, W.C.2
  • 4
    • 84876990097 scopus 로고    scopus 로고
    • Protein phosphatase 2A: a target for anticancer therapy
    • Perrotti D and Neviani P. Protein phosphatase 2A: a target for anticancer therapy. The lancet oncology. 2013; 14(6):e229-238.
    • (2013) The lancet oncology , vol.14 , Issue.6
    • Perrotti, D.1    Neviani, P.2
  • 5
    • 79953000069 scopus 로고    scopus 로고
    • Protein phosphatase 2A as a potential target for anticancer therapy
    • Kalev P and Sablina AA. Protein phosphatase 2A as a potential target for anticancer therapy. Anti-cancer agents in medicinal chemistry. 2011; 11(1):38-46.
    • (2011) Anti-cancer agents in medicinal chemistry , vol.11 , Issue.1 , pp. 38-46
    • Kalev, P.1    Sablina, A.A.2
  • 6
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Genes & development. 2000; 14(15):1837-1851.
    • (2000) Genes & development , vol.14 , Issue.15 , pp. 1837-1851
    • Polakis, P.1
  • 10
    • 37749015044 scopus 로고    scopus 로고
    • A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC
    • Eichhorn PJ, Creyghton MP, Wilhelmsen K, van Dam H and Bernards R. A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC. PLoS genetics. 2007; 3(12):e218.
    • (2007) PLoS genetics , vol.3 , Issue.12
    • Eichhorn, P.J.1    Creyghton, M.P.2    Wilhelmsen, K.3    van Dam, H.4    Bernards, R.5
  • 11
    • 33645232372 scopus 로고    scopus 로고
    • Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation
    • Arnold HK and Sears RC. Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation. Molecular and cellular biology. 2006; 26(7):2832-2844.
    • (2006) Molecular and cellular biology , vol.26 , Issue.7 , pp. 2832-2844
    • Arnold, H.K.1    Sears, R.C.2
  • 12
    • 34447106751 scopus 로고    scopus 로고
    • PP2A: unveiling a reluctant tumor suppressor
    • Mumby M. PP2A: unveiling a reluctant tumor suppressor. Cell. 2007; 130(1):21-24.
    • (2007) Cell , vol.130 , Issue.1 , pp. 21-24
    • Mumby, M.1
  • 13
    • 66549085133 scopus 로고    scopus 로고
    • The role of PP2A A subunits in tumor suppression
    • Sablina AA and Hahn WC. The role of PP2A A subunits in tumor suppression. Cell adhesion & migration. 2007; 1(3):140-141.
    • (2007) Cell adhesion & migration , vol.1 , Issue.3 , pp. 140-141
    • Sablina, A.A.1    Hahn, W.C.2
  • 14
    • 84888337350 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target
    • Khanna A, Pimanda JE and Westermarck J. Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target. Cancer research. 2013; 73(22):6548-6553.
    • (2013) Cancer research , vol.73 , Issue.22 , pp. 6548-6553
    • Khanna, A.1    Pimanda, J.E.2    Westermarck, J.3
  • 15
    • 85039614948 scopus 로고    scopus 로고
    • Functions of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Role in Breast Oncogenesis communicated
    • De P, Carlson J, Leyland-Jones B and Dey N. Functions of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A): Role in Breast Oncogenesis communicated. 2014.
    • (2014)
    • De, P.1    Carlson, J.2    Leyland-Jones, B.3    Dey, N.4
  • 18
    • 84888380323 scopus 로고    scopus 로고
    • CIP2A modulates cell-cycle progression in human cancer cells by regulating the stability and activity of Plk1
    • Kim JS, Kim EJ, Oh JS, Park IC and Hwang SG. CIP2A modulates cell-cycle progression in human cancer cells by regulating the stability and activity of Plk1. Cancer research. 2013; 73(22):6667-6678.
    • (2013) Cancer research , vol.73 , Issue.22 , pp. 6667-6678
    • Kim, J.S.1    Kim, E.J.2    Oh, J.S.3    Park, I.C.4    Hwang, S.G.5
  • 19
    • 84891676480 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity
    • Jeong AL, Lee S, Park JS, Han S, Jang CY, Lim JS, Lee MS and Yang Y. Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity. The Journal of biological chemistry. 2014; 289(1):28-40.
    • (2014) The Journal of biological chemistry , vol.289 , Issue.1 , pp. 28-40
    • Jeong, A.L.1    Lee, S.2    Park, J.S.3    Han, S.4    Jang, C.Y.5    Lim, J.S.6    Lee, M.S.7    Yang, Y.8
  • 22
    • 84905019489 scopus 로고    scopus 로고
    • Chk1-CIP2A pathway independent of ATM-ATR
    • AACR 102nd Annual Meeting, (Orlando FL: Cancer Research).
    • Khanna A. BC, Schreck I., Weiss C., Visakorpi T., Ristimaki A., Westermarck J. (2011). Chk1-CIP2A pathway independent of ATM-ATR. AACR 102nd Annual Meeting. (Orlando FL: Cancer Research).
    • (2011)
    • Khanna, A.B.C.1    Schreck, I.2    Weiss, C.3    Visakorpi, T.4    Ristimaki, A.5    Westermarck, J.6
  • 25
    • 84893874777 scopus 로고    scopus 로고
    • Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells
    • Zhao Y, Li Y, Han J, Liu T, Guan Q, Zhao P, Guo L, Liu K and He D. Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells. International journal of molecular medicine. 2014; 33(3):703-710.
    • (2014) International journal of molecular medicine , vol.33 , Issue.3 , pp. 703-710
    • Zhao, Y.1    Li, Y.2    Han, J.3    Liu, T.4    Guan, Q.5    Zhao, P.6    Guo, L.7    Liu, K.8    He, D.9
  • 27
    • 41849140001 scopus 로고    scopus 로고
    • Mechanisms of MYC stabilization in human malignancies
    • Junttila MR and Westermarck J. Mechanisms of MYC stabilization in human malignancies. Cell cycle. 2008; 7(5):592-596.
    • (2008) Cell cycle , vol.7 , Issue.5 , pp. 592-596
    • Junttila, M.R.1    Westermarck, J.2
  • 29
  • 30
    • 84880544460 scopus 로고    scopus 로고
    • Nutrients and growth factors in mTORC1 activation
    • Efeyan A and Sabatini DM. Nutrients and growth factors in mTORC1 activation. Biochemical Society transactions. 2013; 41(4):902-905.
    • (2013) Biochemical Society transactions , vol.41 , Issue.4 , pp. 902-905
    • Efeyan, A.1    Sabatini, D.M.2
  • 33
    • 84863370079 scopus 로고    scopus 로고
    • NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations
    • Park E, Park J, Han SW, Im SA, Kim TY, Oh DY and Bang YJ. NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. International journal of oncology. 2012; 40(4):1259-1266.
    • (2012) International journal of oncology , vol.40 , Issue.4 , pp. 1259-1266
    • Park, E.1    Park, J.2    Han, S.W.3    Im, S.A.4    Kim, T.Y.5    Oh, D.Y.6    Bang, Y.J.7
  • 36
    • 1442285922 scopus 로고    scopus 로고
    • PP2A fulfills its promises as tumor suppressor: which subunits are important?
    • Van Hoof C and Goris J. PP2A fulfills its promises as tumor suppressor: which subunits are important? Cancer cell. 2004; 5(2):105-106.
    • (2004) Cancer cell , vol.5 , Issue.2 , pp. 105-106
    • Van Hoof, C.1    Goris, J.2
  • 37
    • 0037173724 scopus 로고    scopus 로고
    • Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer
    • Soo Hoo L, Zhang JY and Chan EK. Cloning and characterization of a novel 90 kDa 'companion' auto-antigen of p62 overexpressed in cancer. Oncogene. 2002; 21(32):5006-5015.
    • (2002) Oncogene , vol.21 , Issue.32 , pp. 5006-5015
    • Soo Hoo, L.1    Zhang, J.Y.2    Chan, E.K.3
  • 38
    • 84899487649 scopus 로고    scopus 로고
    • miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3zeta
    • Jung HM, Phillips BL and Chan EK. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3zeta. Molecular cancer. 2014; 13:80.
    • (2014) Molecular cancer , vol.13 , pp. 80
    • Jung, H.M.1    Phillips, B.L.2    Chan, E.K.3
  • 43
    • 84890285097 scopus 로고    scopus 로고
    • The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma
    • Sung WW and Lee H. The role of interleukin-10 in the progression of human papillomavirus-associated lung carcinoma. Oncoimmunology. 2013; 2(9):e25854.
    • (2013) Oncoimmunology , vol.2 , Issue.9
    • Sung, W.W.1    Lee, H.2
  • 46
    • 84864061682 scopus 로고    scopus 로고
    • CIP2A is overexpressed in esophageal squamous cell carcinoma
    • Qu W, Li W, Wei L, Xing L, Wang X and Yu J. CIP2A is overexpressed in esophageal squamous cell carcinoma. Medical oncology. 2012; 29(1):113-118.
    • (2012) Medical oncology , vol.29 , Issue.1 , pp. 113-118
    • Qu, W.1    Li, W.2    Wei, L.3    Xing, L.4    Wang, X.5    Yu, J.6
  • 53
    • 84876003305 scopus 로고    scopus 로고
    • Expression and biological role of CIP2A in human astrocytoma
    • Yi F, Ni W, Liu W, Bai J and Li W. Expression and biological role of CIP2A in human astrocytoma. Molecular medicine reports. 2013; 7(5):1376-1380.
    • (2013) Molecular medicine reports , vol.7 , Issue.5 , pp. 1376-1380
    • Yi, F.1    Ni, W.2    Liu, W.3    Bai, J.4    Li, W.5
  • 56
    • 84892448216 scopus 로고    scopus 로고
    • Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
    • Kang J, Sergio CM, Sutherland RL and Musgrove EA. Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells. BMC Cancer. 2014; 14:32.
    • (2014) BMC Cancer , vol.14 , pp. 32
    • Kang, J.1    Sergio, C.M.2    Sutherland, R.L.3    Musgrove, E.A.4
  • 57
    • 84874643751 scopus 로고    scopus 로고
    • Clinical implications of CIP2A protein expression in breast cancer
    • Yu G, Liu G, Dong J and Jin Y. Clinical implications of CIP2A protein expression in breast cancer. Medical oncology. 2013; 30(2):524.
    • (2013) Medical oncology , vol.30 , Issue.2 , pp. 524
    • Yu, G.1    Liu, G.2    Dong, J.3    Jin, Y.4
  • 59
    • 84905035215 scopus 로고    scopus 로고
    • Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720
    • Baldacchino S, Saliba C, Petroni V, Fenech AG, Borg N and Grech G. Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720. The EPMA journal. 2014; 5(1):3.
    • (2014) The EPMA journal , vol.5 , Issue.1 , pp. 3
    • Baldacchino, S.1    Saliba, C.2    Petroni, V.3    Fenech, A.G.4    Borg, N.5    Grech, G.6
  • 64
    • 84879572982 scopus 로고    scopus 로고
    • Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis
    • Xu P, Huang Q, Xie F, Xu XL and Shao F. Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis. Hepato-gastroenterology. 2013; 60(124):669-672.
    • (2013) Hepato-gastroenterology , vol.60 , Issue.124 , pp. 669-672
    • Xu, P.1    Huang, Q.2    Xie, F.3    Xu, X.L.4    Shao, F.5
  • 65
    • 84856019028 scopus 로고    scopus 로고
    • Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival
    • Ren J, Li W, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H and Xu Z. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. British journal of cancer. 2011; 105(12):1905-1911.
    • (2011) British journal of cancer , vol.105 , Issue.12 , pp. 1905-1911
    • Ren, J.1    Li, W.2    Yan, L.3    Jiao, W.4    Tian, S.5    Li, D.6    Tang, Y.7    Gu, G.8    Liu, H.9    Xu, Z.10
  • 68
    • 79960467126 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein
    • Liu J, Wang X, Zhou G, Wang H, Xiang L, Cheng Y, Liu W, Wang Y, Jia J and Zhao W. Cancerous inhibitor of protein phosphatase 2A is overexpressed in cervical cancer and upregulated by human papillomavirus 16 E7 oncoprotein. Gynecologic oncology. 2011; 122(2):430-436.
    • (2011) Gynecologic oncology , vol.122 , Issue.2 , pp. 430-436
    • Liu, J.1    Wang, X.2    Zhou, G.3    Wang, H.4    Xiang, L.5    Cheng, Y.6    Liu, W.7    Wang, Y.8    Jia, J.9    Zhao, W.10
  • 71
    • 77957578394 scopus 로고    scopus 로고
    • The role of CIP2A in oral squamous cell carcinoma
    • Basile JR and Czerninski R. The role of CIP2A in oral squamous cell carcinoma. Cancer biology & therapy. 2010; 10(7):700-702.
    • (2010) Cancer biology & therapy , vol.10 , Issue.7 , pp. 700-702
    • Basile, J.R.1    Czerninski, R.2
  • 77
    • 79952925941 scopus 로고    scopus 로고
    • CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation
    • Wang J, Li W, Li L, Yu X, Jia J and Chen C. CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. International journal of laboratory hematology. 2011; 33(3):290-298.
    • (2011) International journal of laboratory hematology , vol.33 , Issue.3 , pp. 290-298
    • Wang, J.1    Li, W.2    Li, L.3    Yu, X.4    Jia, J.5    Chen, C.6
  • 80
    • 79959252521 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
    • Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR and Clark RE. Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood. 2011; 117(24):6660-6668.
    • (2011) Blood , vol.117 , Issue.24 , pp. 6660-6668
    • Lucas, C.M.1    Harris, R.J.2    Giannoudis, A.3    Copland, M.4    Slupsky, J.R.5    Clark, R.E.6
  • 83
    • 79954449794 scopus 로고    scopus 로고
    • PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect
    • Cristobal I, Garcia-Orti L, Cirauqui C, Alonso MM, Calasanz MJ and Odero MD. PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect. Leukemia. 2011; 25(4):606-614.
    • (2011) Leukemia , vol.25 , Issue.4 , pp. 606-614
    • Cristobal, I.1    Garcia-Orti, L.2    Cirauqui, C.3    Alonso, M.M.4    Calasanz, M.J.5    Odero, M.D.6
  • 84
    • 84859449771 scopus 로고    scopus 로고
    • Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia
    • Cristobal I, Garcia-Orti L, Cirauqui C, Cortes-Lavaud X, Garcia-Sanchez MA, Calasanz MJ and Odero MD. Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia. Haematologica. 2012; 97(4):543-550.
    • (2012) Haematologica , vol.97 , Issue.4 , pp. 543-550
    • Cristobal, I.1    Garcia-Orti, L.2    Cirauqui, C.3    Cortes-Lavaud, X.4    Garcia-Sanchez, M.A.5    Calasanz, M.J.6    Odero, M.D.7
  • 87
    • 79952916409 scopus 로고    scopus 로고
    • ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells
    • Khanna A, Okkeri J, Bilgen T, Tiirikka T, Vihinen M, Visakorpi T and Westermarck J. ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. PloS one. 2011; 6(3):e17979.
    • (2011) PloS one , vol.6 , Issue.3
    • Khanna, A.1    Okkeri, J.2    Bilgen, T.3    Tiirikka, T.4    Vihinen, M.5    Visakorpi, T.6    Westermarck, J.7
  • 88
    • 84872191898 scopus 로고    scopus 로고
    • Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells
    • Pallai R, Bhaskar A, Sodi V and Rice LM. Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells. Transcription. 2012; 3(6):323-335.
    • (2012) Transcription , vol.3 , Issue.6 , pp. 323-335
    • Pallai, R.1    Bhaskar, A.2    Sodi, V.3    Rice, L.M.4
  • 90
    • 84890904236 scopus 로고    scopus 로고
    • Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition
    • Hou DR, Huang AC, Shiau CW, Wang CY, Yu HC and Chen KF. Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition. Molecules. 2013; 18(12):15398-15411.
    • (2013) Molecules , vol.18 , Issue.12 , pp. 15398-15411
    • Hou, D.R.1    Huang, A.C.2    Shiau, C.W.3    Wang, C.Y.4    Yu, H.C.5    Chen, K.F.6
  • 91
    • 78649511007 scopus 로고    scopus 로고
    • CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
    • Chen KF, Liu CY, Lin YC, Yu HC, Liu TH, Hou DR, Chen PJ and Cheng AL. CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene. 2010; 29(47):6257-6266.
    • (2010) Oncogene , vol.29 , Issue.47 , pp. 6257-6266
    • Chen, K.F.1    Liu, C.Y.2    Lin, Y.C.3    Yu, H.C.4    Liu, T.H.5    Hou, D.R.6    Chen, P.J.7    Cheng, A.L.8
  • 92
    • 84877065711 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells
    • Liu CY, Shiau CW, Kuo HY, Huang HP, Chen MH, Tzeng CH and Chen KF. Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells. Haematologica. 2013; 98(5):729-738.
    • (2013) Haematologica , vol.98 , Issue.5 , pp. 729-738
    • Liu, C.Y.1    Shiau, C.W.2    Kuo, H.Y.3    Huang, H.P.4    Chen, M.H.5    Tzeng, C.H.6    Chen, K.F.7
  • 93
    • 85039620758 scopus 로고    scopus 로고
    • Identify and evaluate novel biomarker CIP2A for cervical cancer diagnostics
    • AACR 102nd Annual Meeting. (Orlando Florida: Cancer Research).
    • Huang LP, Libby, E, Trama, J. (2011). Identify and evaluate novel biomarker CIP2A for cervical cancer diagnostics. AACR 102nd Annual Meeting. (Orlando Florida: Cancer Research).
    • (2011)
    • Huang, L.P.1    Libby, E.2    Trama, J.3
  • 94
    • 85039619998 scopus 로고    scopus 로고
    • Cancerous Inihibitor of PP2A (CIP2A) expression for bladder cancer diagnosis
    • Huang L. AM, Mordechai E., Trama J. (2011). Cancerous Inihibitor of PP2A (CIP2A) expression for bladder cancer diagnosis. AACR Cancer Research).
    • (2011) AACR Cancer Research
    • Huang, L.A.M.1    Mordechai, E.2    Trama, J.3
  • 96
    • 84872761431 scopus 로고    scopus 로고
    • CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis
    • Xu P, Xu XL, Huang Q, Zhang ZH and Zhang YB. CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis. Medical oncology. 2012; 29(3):1643-1647.
    • (2012) Medical oncology , vol.29 , Issue.3 , pp. 1643-1647
    • Xu, P.1    Xu, X.L.2    Huang, Q.3    Zhang, Z.H.4    Zhang, Y.B.5
  • 100
    • 84904967362 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
    • Liu Z, Ma L, Wen ZS, Hu Z, Wu FQ, Li W, Liu J and Zhou GB. Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer. Carcinogenesis. 2013.
    • (2013) Carcinogenesis
    • Liu, Z.1    Ma, L.2    Wen, Z.S.3    Hu, Z.4    Wu, F.Q.5    Li, W.6    Liu, J.7    Zhou, G.B.8
  • 101
    • 84883333001 scopus 로고    scopus 로고
    • Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells
    • Cantini L, Attaway CC, Butler B, Andino LM, Sokolosky ML and Jakymiw A. Fusogenic-oligoarginine peptide-mediated delivery of siRNAs targeting the CIP2A oncogene into oral cancer cells. PloS one. 2013; 8(9):e73348.
    • (2013) PloS one , vol.8 , Issue.9
    • Cantini, L.1    Attaway, C.C.2    Butler, B.3    Andino, L.M.4    Sokolosky, M.L.5    Jakymiw, A.6
  • 102
    • 84894056181 scopus 로고    scopus 로고
    • Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells
    • Liu Z, Ma L, Wen ZS, Cheng Y-X and Zhou GB. Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells. ACS Med Chem Lett. 2014; 5(2):113-118.
    • (2014) ACS Med Chem Lett , vol.5 , Issue.2 , pp. 113-118
    • Liu, Z.1    Ma, L.2    Wen, Z.S.3    Cheng, Y.-X.4    Zhou, G.B.5
  • 103
    • 84904967363 scopus 로고    scopus 로고
    • Development of Erlotinib derivatives as CIP2A inhibitors
    • AACR 103rd Annual meeting. (Chicago IL: Cancer Research).
    • Shiau C-W. (2012). Development of Erlotinib derivatives as CIP2A inhibitors. AACR 103rd Annual meeting. (Chicago IL: Cancer Research).
    • (2012)
    • Shiau, C.-W.1
  • 107
    • 84873273329 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome
    • Yu HC, Hou DR, Liu CY, Lin CS, Shiau CW, Cheng AL and Chen KF. Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome. PloS one. 2013; 8(2):e55705.
    • (2013) PloS one , vol.8 , Issue.2
    • Yu, H.C.1    Hou, D.R.2    Liu, C.Y.3    Lin, C.S.4    Shiau, C.W.5    Cheng, A.L.6    Chen, K.F.7
  • 108
    • 84862790962 scopus 로고    scopus 로고
    • CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells
    • Lin YC, Chen KC, Chen CC, Cheng AL and Chen KF. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral oncology. 2012; 48(7):585-593.
    • (2012) Oral oncology , vol.48 , Issue.7 , pp. 585-593
    • Lin, Y.C.1    Chen, K.C.2    Chen, C.C.3    Cheng, A.L.4    Chen, K.F.5
  • 110
    • 84856343866 scopus 로고    scopus 로고
    • Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A
    • Huang CY, Wei CC, Chen KC, Chen HJ, Cheng AL and Chen KF. Bortezomib enhances radiation-induced apoptosis in solid tumors by inhibiting CIP2A. Cancer letters. 2012; 317(1):9-15.
    • (2012) Cancer letters , vol.317 , Issue.1 , pp. 9-15
    • Huang, C.Y.1    Wei, C.C.2    Chen, K.C.3    Chen, H.J.4    Cheng, A.L.5    Chen, K.F.6
  • 115
    • 84900421919 scopus 로고    scopus 로고
    • Doubling Down on the PI3K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness
    • De P, Sun Y, Carlson JH, Friedman LS, Leyland-Jones BR and Dey N. Doubling Down on the PI3K-AKT-mTOR Pathway Enhances the Antitumor Efficacy of PARP Inhibitor in Triple Negative Breast Cancer Model beyond BRCA-ness. Neoplasia. 2014; 16(1):43-72.
    • (2014) Neoplasia , vol.16 , Issue.1 , pp. 43-72
    • De, P.1    Sun, Y.2    Carlson, J.H.3    Friedman, L.S.4    Leyland-Jones, B.R.5    Dey, N.6
  • 116
    • 84899486834 scopus 로고    scopus 로고
    • Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis
    • Avtanski DB, Nagalingam A, Bonner MY, Arbiser JL, Saxena NK and Sharma D. Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis. Mol Oncol. 2014.
    • (2014) Mol Oncol
    • Avtanski, D.B.1    Nagalingam, A.2    Bonner, M.Y.3    Arbiser, J.L.4    Saxena, N.K.5    Sharma, D.6
  • 118
    • 84891351058 scopus 로고    scopus 로고
    • Nox4-derived ROS signaling contributes to TGF-beta-induced epithelial-mesenchymal transition in pancreatic cancer cells
    • Hiraga R, Kato M, Miyagawa S and Kamata T. Nox4-derived ROS signaling contributes to TGF-beta-induced epithelial-mesenchymal transition in pancreatic cancer cells. Anticancer Res. 2013; 33(10):4431-4438.
    • (2013) Anticancer Res , vol.33 , Issue.10 , pp. 4431-4438
    • Hiraga, R.1    Kato, M.2    Miyagawa, S.3    Kamata, T.4
  • 120
    • 84875733869 scopus 로고    scopus 로고
    • Focus issue: From genomic mutations to oncogenic pathways
    • Gough NR. Focus issue: From genomic mutations to oncogenic pathways. Science signaling. 2013; 6(268):eg3.
    • (2013) Science signaling , vol.6 , Issue.268
    • Gough, N.R.1
  • 122
    • 79952925941 scopus 로고    scopus 로고
    • CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation
    • Wang J, Li W, Li L, Yu X, Jia J and Chen C. CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. International journal of laboratory hematology. 2011; 33(3):290-298.
    • (2011) International journal of laboratory hematology , vol.33 , Issue.3 , pp. 290-298
    • Wang, J.1    Li, W.2    Li, L.3    Yu, X.4    Jia, J.5    Chen, C.6
  • 123
    • 84876003305 scopus 로고    scopus 로고
    • Expression and biological role of CIP2A in human astrocytoma
    • Yi F, Ni W, Liu W, Bai J and Li W. Expression and biological role of CIP2A in human astrocytoma. Molecular medicine reports. 2013; 7(5):1376-1380.
    • (2013) Molecular medicine reports , vol.7 , Issue.5 , pp. 1376-1380
    • Yi, F.1    Ni, W.2    Liu, W.3    Bai, J.4    Li, W.5
  • 126
    • 84874643751 scopus 로고    scopus 로고
    • Clinical implications of CIP2A protein expression in breast cancer
    • Yu G, Liu G, Dong J and Jin Y. Clinical implications of CIP2A protein expression in breast cancer. Medical oncology. 2013; 30(2):524.
    • (2013) Medical oncology , vol.30 , Issue.2 , pp. 524
    • Yu, G.1    Liu, G.2    Dong, J.3    Jin, Y.4
  • 132
    • 84879572982 scopus 로고    scopus 로고
    • Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis
    • Xu P, Huang Q, Xie F, Xu XL and Shao F. Increased expression of CIP2A in cholangiocarcinoma and correlation with poor prognosis. Hepato-gastroenterology. 2013; 60(124):669-672.
    • (2013) Hepato-gastroenterology , vol.60 , Issue.124 , pp. 669-672
    • Xu, P.1    Huang, Q.2    Xie, F.3    Xu, X.L.4    Shao, F.5
  • 140
    • 84893874777 scopus 로고    scopus 로고
    • Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells
    • Zhao Y, Li Y, Han J, Liu T, Guan Q, Zhao P, Guo L, Liu K and He D. Helicobacter pylori enhances CIP2A expression and cell proliferation via JNK2/ATF2 signaling in human gastric cancer cells. International journal of molecular medicine. 2014; 33(3):703-710.
    • (2014) International journal of molecular medicine , vol.33 , Issue.3 , pp. 703-710
    • Zhao, Y.1    Li, Y.2    Han, J.3    Liu, T.4    Guan, Q.5    Zhao, P.6    Guo, L.7    Liu, K.8    He, D.9
  • 141
    • 84862790962 scopus 로고    scopus 로고
    • CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells
    • Lin YC, Chen KC, Chen CC, Cheng AL and Chen KF. CIP2A-mediated Akt activation plays a role in bortezomib-induced apoptosis in head and neck squamous cell carcinoma cells. Oral oncology. 2012; 48(7):585-593.
    • (2012) Oral oncology , vol.48 , Issue.7 , pp. 585-593
    • Lin, Y.C.1    Chen, K.C.2    Chen, C.C.3    Cheng, A.L.4    Chen, K.F.5
  • 148
    • 84872761431 scopus 로고    scopus 로고
    • CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis
    • Xu P, Xu XL, Huang Q, Zhang ZH and Zhang YB. CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis. Medical oncology. 2012; 29(3):1643-1647.
    • (2012) Medical oncology , vol.29 , Issue.3 , pp. 1643-1647
    • Xu, P.1    Xu, X.L.2    Huang, Q.3    Zhang, Z.H.4    Zhang, Y.B.5
  • 150
    • 84894042781 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer
    • Liu Z, Ma L, Wen ZS, Hu Z, Wu FQ, Li W, Liu J and Zhou GB. Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer. Carcinogenesis. 2014; 35(4):905-914.
    • (2014) Carcinogenesis , vol.35 , Issue.4 , pp. 905-914
    • Liu, Z.1    Ma, L.2    Wen, Z.S.3    Hu, Z.4    Wu, F.Q.5    Li, W.6    Liu, J.7    Zhou, G.B.8
  • 152
    • 77957578394 scopus 로고    scopus 로고
    • The role of CIP2A in oral squamous cell carcinoma
    • Basile JR and Czerninski R. The role of CIP2A in oral squamous cell carcinoma. Cancer biology & therapy. 2010; 10(7):700-702.
    • (2010) Cancer biology & therapy , vol.10 , Issue.7 , pp. 700-702
    • Basile, J.R.1    Czerninski, R.2
  • 157
    • 84856019028 scopus 로고    scopus 로고
    • Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival
    • Ren J, Li W, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H and Xu Z. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. British journal of cancer. 2011; 105(12):1905-1911.
    • (2011) British journal of cancer , vol.105 , Issue.12 , pp. 1905-1911
    • Ren, J.1    Li, W.2    Yan, L.3    Jiao, W.4    Tian, S.5    Li, D.6    Tang, Y.7    Gu, G.8    Liu, H.9    Xu, Z.10


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