Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 20, 2012, Pages 6144-6153

  Chen, Kuen Feng ^b   Pao, Kuan Chuan ^a   Su, Jung Chen ^a   Chou, Yi Chieh ^b   Liu, Chun Yu ^a,c   Chen, Hui Ju ^b   Huang, Jui Wen ^d   Kim, Inki ^e   Shiau, Chung Wai ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^e Asan Medical Center   (South Korea)

Author keywords

CIP2A; Erlotinib; HCC; Pyrimidine; Quinazoline

Indexed keywords

2 CHLORO 6,7 DIMETHOXY N (4 PHENOXYPHENYL)QUINAZOLIN 4 AMINE; 2 CHLORO N (2 FLUORO 5 METHYLOPHENYL) 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; 2 CHLORO N (3 CHLOROPHENYL) 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; 2 CHLORO N (3 CHLOROPHENYL)PYRIMIDIN 4 AMINE; 2 CHLORO N (3 ETHYNYLPHENYL) 6,7 DIMETHOXY N METHYLQUINAZOLIN 4 AMINE; 2 CHLORO N (3 ETHYNYLPHENYL) 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; 2 CHLORO N (3 ETHYNYLPHENYL)PYRIMIDIN 4 AMINE; 2 CHLORO N (4 PHENOXYPHENYL)PYRIMIDIN 4 AMINE; 2 CHLORO N [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; 2 CHLORO N [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]PYRIMIDIN 4 AMINE; 3 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)PHENOL; 4 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO) 3 METHYPHENOL; 4 [3 (2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 YLAMINO)PHENOXY]BENZONITRILE; CANCEROUS INHIBITOR OF PP2A PROTEIN; EPIDERMAL GROWTH FACTOR; ERLOTINIB; N BENZYL 2 CHLORO 6,7 DIMETHOXYQUINAZOLIN 4 AMINE; N BENZYL 2 CHLOROPYRIMIDIN 4 AMINE; N2 (3 CHLOROPHENYL) N4 (ETHYNYLPHENYL) 6,7 DIMETHOXYQUINAZOLINE 2,4 DIAMINE; N2 [4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL] N4 (3 ETHYNYLPHENYL) 6,7 DIMETHOXYQUINAZOLINE 2,4 DIAMINE; N2 BENZYL N4 (ETHYNYLPHENYL) 6,7 DIMETHOXYQUINAZOLINE 2,4 DIAMINE; N2,N4 BIS(3 ETHYNYLPHENYL)PYRIMIDINE 2,4 DIAMINE; N2,N4 BIS[4 CHLORO 3 (TRIFLUOROMETHYL)PHENYL]PYRIMIDINE 2,4 DIAMINE; N4 (3 ETHYNYLPHENYL) 6,7 DIMETHOXY N2 (4 PHENOXYPHENYL)QUINAZOLINE 2,4 DIAMINE; N4 (ETHYNYLPHENYL) N2 (2 FLUORO 5 METHYLPHENYL) 6,7 DIMETHOXYQUINAZOLINE 2,4 DIAMINE; ONCOPROTEIN; PROTEIN KINASE B; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; PROTEIN PHOSPHATASE 2; PYRIMIDINES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84866922110     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.039     Document Type: Article

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