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Volumn 31, Issue 3, 2012, Pages 390-401

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

Author keywords

ATF3; c Myc; CIP2A; JNK knockout; Ras transformation

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVATING TRANSCRIPTION FACTOR 3; CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 9; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; RAS PROTEIN; SERINE; UNCLASSIFIED DRUG;

EID: 84855913352     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.230     Document Type: Article
Times cited : (39)

References (65)
  • 1
    • 1042289729 scopus 로고    scopus 로고
    • 2 Kinase (JNK) Contributes to the Regulation of c-Myc Protein Stability
    • DOI 10.1074/jbc.M312054200
    • Alarcon-Vargas D, Ronai Z. (2004). c-Jun-NH2 kinase (JNK) contributes to the regulation of c-Myc protein stability. J Biol Chem 279: 5008-5016. (Pubitemid 38199097)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.6 , pp. 5008-5016
    • Alarcon-Vargas, D.1    Ronai, Z.2
  • 3
    • 0034682264 scopus 로고    scopus 로고
    • Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
    • Behrens A, Jochum W, Sibilia M, Wagner EF. (2000). Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 19: 2657-2663. (Pubitemid 30326415)
    • (2000) Oncogene , vol.19 , Issue.22 , pp. 2657-2663
    • Behrens, A.1    Jochum, W.2    Sibilia, M.3    Wagner, E.F.4
  • 4
    • 0346365379 scopus 로고    scopus 로고
    • Subcellular Localization of Activating Transcription Factor 2 in Melanoma Specimens Predicts Patient Survival
    • Berger AJ, Kluger HM, Li N, Kielhorn E, Halaban R, Ronai Z et al. (2003). Subcellular localization of activating transcription factor 2 in melanoma specimens predicts patient survival. Cancer Res 63: 8103-8107. (Pubitemid 37549453)
    • (2003) Cancer Research , vol.63 , Issue.23 , pp. 8103-8107
    • Berger, A.J.1    Kluger, H.M.2    Li, N.3    Kielhorn, E.4    Halaban, R.5    Ronai, Z.6    Rimm, D.L.7
  • 5
    • 8544259596 scopus 로고    scopus 로고
    • Inhibition of melanoma growth and metastasis by ATF2-derived peptides
    • DOI 10.1158/0008-5472.CAN-04-0714
    • Bhoumik A, Gangi L, Ronai Z. (2004). Inhibition of melanoma growth and metastasis by ATF2-derived peptides. Cancer Res 64: 8222-8230. (Pubitemid 39491759)
    • (2004) Cancer Research , vol.64 , Issue.22 , pp. 8222-8230
    • Bhoumik, A.1    Gangi, L.2    Ronai, Z.3
  • 6
    • 48849111311 scopus 로고    scopus 로고
    • ATF2: A transcription factor that elicits oncogenic or tumor suppressor activities
    • Bhoumik A, Ronai Z. (2008). ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. Cell Cycle 7: 2341-2345.
    • (2008) Cell Cycle , vol.7 , pp. 2341-2345
    • Bhoumik, A.1    Ronai, Z.2
  • 7
    • 0025806587 scopus 로고
    • Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
    • Binetruy B, Smeal T, Karin M. (1991). Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature 351: 122-127. (Pubitemid 21896543)
    • (1991) Nature , vol.351 , Issue.6322 , pp. 122-127
    • Binetruy, B.1    Smeal, T.2    Karin, M.3
  • 8
    • 0032980723 scopus 로고    scopus 로고
    • The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
    • Bost F, McKay R, Bost M, Potapova O, Dean NM, Mercola D. (1999). The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol Cell Biol 19: 1938-1949. (Pubitemid 29098252)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.3 , pp. 1938-1949
    • Bost, F.1    McKay, R.2    Bost, M.3    Potapova, O.4    Dean, N.M.5    Mercola, D.6
  • 9
    • 0028079956 scopus 로고
    • Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts
    • Brunet A, Pages G, Pouyssegur J. (1994). Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. Oncogene 9: 3379-3387. (Pubitemid 24338470)
    • (1994) Oncogene , vol.9 , Issue.11 , pp. 3379-3387
    • Brunet, A.1    Pages, G.2    Pouyssegur, J.3
  • 10
    • 0034665653 scopus 로고    scopus 로고
    • Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: Activation of c-Jun NH2-terminal kinase and promoter response element
    • Cai Y, Zhang C, Naea T, Aso T, Tanaka M, Oshiro S et al. (2000). Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood 96: 2140-2148.
    • (2000) Blood , vol.96 , pp. 2140-2148
    • Cai, Y.1    Zhang, C.2    Naea, T.3    Aso, T.4    Tanaka, M.5    Oshiro, S.6
  • 14
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
    • DOI 10.1016/0092-8674(94)90133-3
    • Cowley S, Paterson H, Kemp P, Marshall CJ. (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77: 841-852. (Pubitemid 24187682)
    • (1994) Cell , vol.77 , Issue.6 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.J.4
  • 15
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • DOI 10.1016/0092-8674(94)90380-8
    • Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T et al. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76: 1025-1037. (Pubitemid 24106383)
    • (1994) Cell , vol.76 , Issue.6 , pp. 1025-1037
    • Derijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 17
    • 54349087788 scopus 로고    scopus 로고
    • Myc's broad reach
    • Eilers M, Eisenman RN. (2008). Myc's broad reach. Genes Dev 22: 2755-2766.
    • (2008) Genes Dev , vol.22 , pp. 2755-2766
    • Eilers, M.1    Eisenman, R.N.2
  • 18
    • 0034725037 scopus 로고    scopus 로고
    • Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation
    • DOI 10.1074/jbc.275.17.12560
    • Fuchs SY, Tappin I, Ronai Z. (2000). Stability of the ATF2 transcription factor is regulated by phosphorylation and dephosphorylation. J Biol Chem 275: 12560-12564. (Pubitemid 30241402)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.17 , pp. 12560-12564
    • Fuchs, S.Y.1    Tappin, I.2    Ronai, Z.3
  • 19
    • 0019958484 scopus 로고
    • Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cullular ras gene family
    • Furth ME, Davis LJ, Fleurdelys B, Scolnick EM. (1982). Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus of the cellular ras gene family. J Virol 43: 294-304. (Pubitemid 12084907)
    • (1982) Journal of Virology , vol.43 , Issue.1 , pp. 294-304
    • Furth, M.E.1    Davis, L.J.2    Fleurdelys, B.3    Scolnick, E.M.4
  • 22
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta S, Campbell D, Derijard B, Davis RJ. (1995). Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267: 389-393.
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Derijard, B.3    Davis, R.J.4
  • 23
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi M, Lin A, Smeal T, Minden A, Karin M. (1993). Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7: 2135-2148. (Pubitemid 23336140)
    • (1993) Genes and Development , vol.7 , Issue.11 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 25
    • 0037007430 scopus 로고    scopus 로고
    • Ras-inducible immortalized fibroblasts: Focus formation without cell cycle deregulation
    • DOI 10.1038/sj/onc/1205423
    • Jacobsen K, Groth A, Willumsen BM. (2002). Ras-inducible immortalized fibroblasts: focus formation without cell cycle deregulation. Oncogene 21: 3058-3067. (Pubitemid 34522906)
    • (2002) Oncogene , vol.21 , Issue.19 , pp. 3058-3067
    • Jacobsen, K.1    Groth, A.2    Willumsen, B.M.3
  • 28
    • 0028609209 scopus 로고
    • JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
    • Kallunki T, Su B, Tsigelny I, Sluss HK, Derijard B, Moore G et al. (1994). JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 8: 2996-3007.
    • (1994) Genes Dev , vol.8 , pp. 2996-3007
    • Kallunki, T.1    Su, B.2    Tsigelny, I.3    Sluss, H.K.4    Derijard, B.5    Moore, G.6
  • 29
    • 0028879854 scopus 로고
    • Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA
    • Kawagishi J, Kumabe T, Yoshimoto T, Yamamoto T. (1995). Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA. Genomics 30: 224-232.
    • (1995) Genomics , vol.30 , pp. 224-232
    • Kawagishi, J.1    Kumabe, T.2    Yoshimoto, T.3    Yamamoto, T.4
  • 30
    • 0034636554 scopus 로고    scopus 로고
    • ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
    • DOI 10.1038/35012097
    • Kawasaki H, Schiltz L, Chiu R, Itakura K, Taira K, Nakatani Y et al. (2000). ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature 405: 195-200. (Pubitemid 30313539)
    • (2000) Nature , vol.405 , Issue.6783 , pp. 195-200
    • Kawasaki, H.1    Schiltz, L.2    Chiu, R.3    Itakura, K.4    Taira, K.5    Nakatani, Y.6    Yokoyama, K.K.7
  • 31
    • 77951037489 scopus 로고    scopus 로고
    • The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia
    • Ke H, Harris R, Coloff JL, Jin JY, Leshin B, de Marval PM et al. (2010). The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia. Cancer Res 70: 3080-3088.
    • (2010) Cancer Res , vol.70 , pp. 3080-3088
    • Ke, H.1    Harris, R.2    Coloff, J.L.3    Jin, J.Y.4    Leshin, B.5    De Marval, P.M.6
  • 32
    • 24944535307 scopus 로고    scopus 로고
    • Multistep skin cancer in mice as a model to study the evolution of cancer cells
    • DOI 10.1016/j.semcancer.2005.06.003, PII S1044579X05000362, Somatic Evolution of Cancer Cells
    • Kemp CJ. (2005). Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin Cancer Biol 15: 460-473. (Pubitemid 41318046)
    • (2005) Seminars in Cancer Biology , vol.15 , Issue.6 , pp. 460-473
    • Kemp, C.J.1
  • 34
    • 0029890896 scopus 로고    scopus 로고
    • Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation
    • Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L et al. (1996). Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol 16: 3923-3933.
    • (1996) Mol Cell Biol , vol.16 , pp. 3923-3933
    • Khosravi-Far, R.1    White, M.A.2    Westwick, J.K.3    Solski, P.A.4    Chrzanowska-Wodnicka, M.5    Van Aelst, L.6
  • 35
    • 0025979335 scopus 로고
    • Raf-1 protein kinase is required for growth of induced NIH/3T3 cells
    • Kolch W, Heidecker G, Lloyd P, Rapp UR. (1991). Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 349: 426-428. (Pubitemid 21926105)
    • (1991) Nature , vol.349 , Issue.6308 , pp. 426-428
    • Kolch, W.1    Heidecker, G.2    Lloyd, P.3    Rapp, U.R.4
  • 36
    • 0029805128 scopus 로고    scopus 로고
    • Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway
    • Krautwald S, Büscher D, Kummer V, Buder S, Baccarini M. (1996). Involvement of the protein tyrosine phosphatase SHP-1 in Ras-mediated activation of the mitogen-activated protein kinase pathway. Mol Cell Biol 16: 5955-5963. (Pubitemid 26360955)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.11 , pp. 5955-5963
    • Krautwald, S.1    Buscher, D.2    Kummer, V.3    Buder, S.4    Baccarini, M.5
  • 38
  • 39
    • 0029034251 scopus 로고
    • ATF-2 contains a phosphorylation-dependent transcriptional activation domain
    • Livingstone C, Patel G, Jones N. (1995). ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 14: 1785-1797.
    • (1995) EMBO J , vol.14 , pp. 1785-1797
    • Livingstone, C.1    Patel, G.2    Jones, N.3
  • 40
    • 74049109400 scopus 로고    scopus 로고
    • C-Jun regulates phosphoinositide-dependent kinase 1 transcription: Implication for Akt and protein kinase C activities and melanoma tumorigenesis
    • Lopez-Bergami P, Kim H, Dewing A, Goydos J, Aaronson S, Ronai Z. (2010). c-Jun regulates phosphoinositide-dependent kinase 1 transcription: implication for Akt and protein kinase C activities and melanoma tumorigenesis. J Biol Chem 285: 903-913.
    • (2010) J Biol Chem , vol.285 , pp. 903-913
    • Lopez-Bergami, P.1    Kim, H.2    Dewing, A.3    Goydos, J.4    Aaronson, S.5    Ronai, Z.6
  • 41
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • DOI 10.1038/nrc1097
    • Malumbres M, Barbacid M. (2003). RAS oncogenes: the first 30 years. Nat Rev Cancer 3: 459-465. (Pubitemid 37328850)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.6 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 43
    • 56649107917 scopus 로고    scopus 로고
    • Analysis of Myc-induced histone modifications on target chromatin
    • Martinato F, Cesaroni M, Amati B, Guccione E. (2008). Analysis of Myc-induced histone modifications on target chromatin. PLoS One 3: e3650.
    • (2008) PLoS One , vol.3
    • Martinato, F.1    Cesaroni, M.2    Amati, B.3    Guccione, E.4
  • 44
    • 38749131195 scopus 로고    scopus 로고
    • Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons
    • Mei Y, Yuan Z, Song B, Li D, Ma C, Hu C et al. (2008). Activating transcription factor 3 up-regulated by c-Jun NH(2)-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons. Neuroscience 151: 771-779.
    • (2008) Neuroscience , vol.151 , pp. 771-779
    • Mei, Y.1    Yuan, Z.2    Song, B.3    Li, D.4    Ma, C.5    Hu, C.6
  • 45
    • 33846446722 scopus 로고    scopus 로고
    • 2-terminal kinase 2 is required for Ras transformation independently of activator protein 1
    • DOI 10.1158/0008-5472.CAN-06-2801
    • Nielsen C, Thastrup J, Bottzauw T, Jaattela M, Kallunki T. (2007). c-Jun NH2-terminal kinase 2 is required for Ras transformation independently of activator protein 1. Cancer Res 67: 178-185. (Pubitemid 46142773)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 178-185
    • Nielsen, C.1    Thastrup, J.2    Bottzauw, T.3    Jaattela, M.4    Kallunki, T.5
  • 46
    • 0035912081 scopus 로고    scopus 로고
    • Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: Identification of factor specific requirements
    • DOI 10.1038/sj.onc.1204306
    • Nielsen KH, Gredsted L, Broach JR, Willumsen BM. (2001). Sensitivity of wild type and mutant ras alleles to Ras specific exchange factors: identification of factor specific requirements. Oncogene 20: 2091-2100. (Pubitemid 32424003)
    • (2001) Oncogene , vol.20 , Issue.17 , pp. 2091-2100
    • Nielsen, K.H.1    Gredsted, L.2    Broach, J.R.3    Willumsen, B.M.4
  • 48
    • 78751681684 scopus 로고    scopus 로고
    • Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme
    • Ovaska K, Laakso M, Haapa-Paananen S, Louhimo R, Chen P, Aittomäki V et al. (2010). Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme. Genome Med 2: 65.
    • (2010) Genome Med , vol.2 , pp. 65
    • Ovaska, K.1    Laakso, M.2    Haapa-Paananen, S.3    Louhimo, R.4    Chen, P.5    Aittomäki, V.6
  • 49
    • 34248325701 scopus 로고    scopus 로고
    • The role of PKC and PDK1 in monocyte lineage specification by Ras
    • DOI 10.1182/blood-2006-09-047217
    • Pearn L, Fisher J, Burnett AK, Darley RL. (2007). The role of PKC and PDK1 in monocyte lineage specification by Ras. Blood 109: 4461-4469. (Pubitemid 46743416)
    • (2007) Blood , vol.109 , Issue.10 , pp. 4461-4469
    • Pearn, L.1    Fisher, J.2    Burnett, A.K.3    Darley, R.L.4
  • 50
    • 0035280863 scopus 로고    scopus 로고
    • Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation
    • DOI 10.1038/sj.onc.1204200
    • Perez S, Vial E, van Dam H, Castellazzi M. (2001). Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation. Oncogene 20: 1135-1141. (Pubitemid 32238863)
    • (2001) Oncogene , vol.20 , Issue.9 , pp. 1135-1141
    • Perez, S.1    Vial, E.2    Van Dam, H.3    Castellazzi, M.4
  • 52
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ et al. (1995). Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 270: 7420-7426.
    • (1995) J Biol Chem , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6
  • 53
    • 77649237043 scopus 로고    scopus 로고
    • K-Ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer
    • Schimanski CC, Zimmermann T, Schmidtmann I, Gockel I, Lang H, Galle PR et al. (2010). K-Ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer. Int J Colorectal Dis 25: 181-186.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 181-186
    • Schimanski, C.C.1    Zimmermann, T.2    Schmidtmann, I.3    Gockel, I.4    Lang, H.5    Galle, P.R.6
  • 54
    • 0033082892 scopus 로고    scopus 로고
    • Ras enhances Myc protein stability
    • DOI 10.1016/S1097-2765(00)80308-1
    • Sears R, Leone G, DeGregori J, Nevins JR. (1999). Ras enhances Myc protein stability. Mol Cell 3: 169-179. (Pubitemid 29292618)
    • (1999) Molecular Cell , vol.3 , Issue.2 , pp. 169-179
    • Sears, R.1    Leone, G.2    DeGregori, J.3    Nevins, J.R.4
  • 55
    • 0034306997 scopus 로고    scopus 로고
    • Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
    • Sears R, Nuckolls F, Haura E, Taya Y, Tamai K, Nevins JR. (2000). Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14: 2501-2514.
    • (2000) Genes Dev , vol.14 , pp. 2501-2514
    • Sears, R.1    Nuckolls, F.2    Haura, E.3    Taya, Y.4    Tamai, K.5    Nevins, J.R.6
  • 56
    • 77952411677 scopus 로고    scopus 로고
    • RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes
    • Sharma A, Luke CT, Dower NA, Stone JC, Lorenzo PS. (2010). RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13- acetate in epidermal keratinocytes. J Biol Chem 285: 15724-15730.
    • (2010) J Biol Chem , vol.285 , pp. 15724-15730
    • Sharma, A.1    Luke, C.T.2    Dower, N.A.3    Stone, J.C.4    Lorenzo, P.S.5
  • 57
    • 0025788098 scopus 로고
    • Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
    • Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. (1991). Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494-496. (Pubitemid 21896867)
    • (1991) Nature , vol.354 , Issue.6353 , pp. 494-496
    • Smeal, T.1    Binetruy, B.2    Mercola, D.A.3    Birrer, M.4    Karin, M.5
  • 59
    • 0031836663 scopus 로고    scopus 로고
    • Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes
    • DOI 10.1002/(SICI)1097-4652(199807)176:1<99::AID-JCP12>3.0.CO;2-J
    • Teruel T, Valverde AM, Navarro P, Benito M, Lorenzo M. (1998). Inhibition of PI 3-kinase and RAS blocks IGF-I and insulininduced uncoupling protein 1 gene expression in brown adipocytes. J Cell Physiol 176: 99-109. (Pubitemid 28277200)
    • (1998) Journal of Cellular Physiology , vol.176 , Issue.1 , pp. 99-109
    • Teruel, T.1    Valverde, A.M.2    Navarro, P.3    Benito, M.4    Lorenzo, M.5
  • 61
    • 0028270718 scopus 로고
    • Mitogen-activated protein kinase/extracellular signalregulated protein kinase activation by oncogenes, serum, and 12-Otetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation
    • Troppmair J, Bruder JT, Munoz H, Lloyd PA, Kyriakis J, Banerjee P et al. (1994). Mitogen-activated protein kinase/extracellular signalregulated protein kinase activation by oncogenes, serum, and 12-Otetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem 269: 7030-7035.
    • (1994) J Biol Chem , vol.269 , pp. 7030-7035
    • Troppmair, J.1    Bruder, J.T.2    Munoz, H.3    Lloyd, P.A.4    Kyriakis, J.5    Banerjee, P.6
  • 62
    • 53949098326 scopus 로고    scopus 로고
    • The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
    • Wang A, Arantes S, Yan L, Kiguchi K, McArthur MJ, Sahin A et al. (2008). The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis. BMC Cancer 8: 268.
    • (2008) BMC Cancer , vol.8 , pp. 268
    • Wang, A.1    Arantes, S.2    Yan, L.3    Kiguchi, K.4    McArthur, M.J.5    Sahin, A.6
  • 63
    • 77449142258 scopus 로고    scopus 로고
    • Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
    • Yao D, Brownlee M. (2010). Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 59: 249-255.
    • (2010) Diabetes , vol.59 , pp. 249-255
    • Yao, D.1    Brownlee, M.2
  • 64
    • 41649111514 scopus 로고    scopus 로고
    • A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development
    • DOI 10.1038/sj.onc.1210861, PII 1210861
    • Yin X, Dewille JW, Hai T. (2008). A potential dichotomous role of ATF3, an adaptive-response gene, in cancer development. Oncogene 27: 2118-2127. (Pubitemid 351483383)
    • (2008) Oncogene , vol.27 , Issue.15 , pp. 2118-2127
    • Yin, X.1    DeWille, J.W.2    Hai, T.3
  • 65
    • 0842278571 scopus 로고    scopus 로고
    • An integrated database of genes responsive to the Myc oncogenic transcription factor: Identification of direct genomic targets
    • Zeller KI, Jegga AG, Aronow BJ, O'Donnell KA, Dang CV. (2003). An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets. Genome Biol 4: R69.
    • (2003) Genome Biol , vol.4
    • Zeller, K.I.1    Jegga, A.G.2    Aronow, B.J.3    O'Donnell, K.A.4    Dang, C.V.5


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