Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Kang, Jian ^a   Sergio, C M ^a   Sutherland, Robert L ^a,b   Musgrove, Elizabeth A ^a,b,c  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Breast cancer; Cyclin dependent kinase; MYC; Synthetic lethality

Indexed keywords

BIM PROTEIN; BROXURIDINE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; MYC PROTEIN; PALBOCICLIB; PROTEIN P53; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MEMBRANE PROTEINS; MOLECULAR TARGETED THERAPY; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84892448216     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-32     Document Type: Article

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