CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation

Journal of Cell Biology

Volumn 204, Issue 5, 2014, Pages 713-727

  Puustinen, Pietri ^a   Rytter, Anna ^a   Mortensen, Monika ^a   Kohonen, Pekka ^b,c   Moreira, José M ^a,d   Jäättelä, Marja ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

AMPK, AMP activated protein kinase; ConA, concanamycin A; LDH, lactate dehydrogenase; MTOR, mammalian target of rapamycin; MTT, 3 (4,5 dimethylthiazol 2 yl) 2,5 diphenyltetrazolium bromide; PI3K, phosphoinositide 3 kinase; PP2Ac, PP2A catalytic subunit; qPCR, quantitative PCR; Raptor, regulatory associated protein of TOR; RLuc, Renilla luciferase; TMA, tissue microarray; TOR, target of rapamycin

Indexed keywords

CIP2A PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; ONCOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; BREAST CARCINOMA; CANCER GROWTH; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; GENE CONTROL; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UBIQUITINATION;

AUTOANTIGENS; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; HUMANS; MEMBRANE PROTEINS; MULTIPROTEIN COMPLEXES; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UBIQUITINATION;

EID: 84895750890     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201304012     Document Type: Article

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